2. NF-κB Apoptosis Autophagy Epigenetics Anti-infection
  3. Keap1-Nrf2 Ferroptosis Autophagy Histone Acetyltransferase Epigenetic Reader Domain Mitophagy Influenza Virus
  4. Curcumin-d6

Curcumin-d6  (Synonyms: Diferuloylmethane-d6; Natural Yellow 3-d6; Turmeric yellow-d6)

Cat. No.: HY-N0005S Purity: 98.00%
SDS COA Handling Instructions

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Curcumin-d6is a deuterium labeled Curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin is an inhibitor of p300 histone acetylatransferase (HATs) and also shows inhibitory effects on NF-κB and MAPKs.

For research use only. We do not sell to patients.

Curcumin-d<sub>6</sub> Chemical Structure

Curcumin-d6 Chemical Structure

CAS No. : 1246833-26-0

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1 mg USD 105 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Curcumin-d6:

Curcumin-d6 Related Antibodies

Top Publications Citing Use of Products

View All Histone Acetyltransferase Isoform Specific Products:

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CBP/p300 GCN5/PCAF TIP60 MOZ/MORF HBO1

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Description

Curcumin-d6is a deuterium labeled Curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin is an inhibitor of p300 histone acetylatransferase (HATs) and also shows inhibitory effects on NF-κB and MAPKs.

IC50 & Target

CBP/p300

 

Molecular Weight

374.42

Formula

C21H14D6O6
CAS No.
Unlabeled CAS

458-37-7
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(CC(/C=C/C1=CC=C(O)C(OC([2H])([2H])[2H])=C1)=O)/C=C/C2=CC=C(O)C(OC([2H])([2H])[2H])=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (267.08 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6708 mL 13.3540 mL 26.7080 mL
5 mM 0.5342 mL 2.6708 mL 5.3416 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.00%

SDS (393 KB)

COA (245 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6708 mL 13.3540 mL 26.7080 mL 66.7699 mL
5 mM 0.5342 mL 2.6708 mL 5.3416 mL 13.3540 mL
10 mM 0.2671 mL 1.3354 mL 2.6708 mL 6.6770 mL
15 mM 0.1781 mL 0.8903 mL 1.7805 mL 4.4513 mL
20 mM 0.1335 mL 0.6677 mL 1.3354 mL 3.3385 mL
25 mM 0.1068 mL 0.5342 mL 1.0683 mL 2.6708 mL
30 mM 0.0890 mL 0.4451 mL 0.8903 mL 2.2257 mL
40 mM 0.0668 mL 0.3338 mL 0.6677 mL 1.6692 mL
50 mM 0.0534 mL 0.2671 mL 0.5342 mL 1.3354 mL
60 mM 0.0445 mL 0.2226 mL 0.4451 mL 1.1128 mL
80 mM 0.0334 mL 0.1669 mL 0.3338 mL 0.8346 mL
100 mM 0.0267 mL 0.1335 mL 0.2671 mL 0.6677 mL
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Curcumin-d6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Curcumin-d61246833-26-0Diferuloylmethane-d6Natural Yellow 3-d6Turmeric yellow-d6Keap1-Nrf2FerroptosisAutophagyHistone AcetyltransferaseEpigenetic Reader DomainMitophagyInfluenza VirusHATsHATMitochondrial Autophagyanti-inflammatoryantioxidantantiproliferativeantiangiogenicactivitiesp300Inhibitorinhibitorinhibit

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