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  3. Isotope-Labeled Compounds
  4. D-Serine-d3

D-Serine-d3 ((R)-Serine-d3) is a deuterium labeled D-Serine (HY-100808). D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration.

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D-Serine-d<sub>3</sub> Chemical Structure

D-Serine-d3 Chemical Structure

CAS No. : 1414348-52-9

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Other Forms of D-Serine-d3:

D-Serine-d3 Related Antibodies

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Description

D-Serine-d3 ((R)-Serine-d3) is a deuterium labeled D-Serine (HY-100808). D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration[1][2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

D-Serine-d3 Related Antibodies
Molecular Weight

108.11

Formula

C3H4D3NO3
CAS No.
Unlabeled CAS

312-84-5
Appearance

Solid

Color

White to off-white

SMILES

OC([C@@](N)([2H])C([2H])([2H])O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (462.49 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 9.2498 mL 46.2492 mL 92.4984 mL
5 mM 1.8500 mL 9.2498 mL 18.4997 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 96.36%

SDS (393 KB)

COA (251 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 9.2498 mL 46.2492 mL 92.4984 mL 231.2460 mL
5 mM 1.8500 mL 9.2498 mL 18.4997 mL 46.2492 mL
10 mM 0.9250 mL 4.6249 mL 9.2498 mL 23.1246 mL
15 mM 0.6167 mL 3.0833 mL 6.1666 mL 15.4164 mL
20 mM 0.4625 mL 2.3125 mL 4.6249 mL 11.5623 mL
25 mM 0.3700 mL 1.8500 mL 3.6999 mL 9.2498 mL
30 mM 0.3083 mL 1.5416 mL 3.0833 mL 7.7082 mL
40 mM 0.2312 mL 1.1562 mL 2.3125 mL 5.7811 mL
50 mM 0.1850 mL 0.9250 mL 1.8500 mL 4.6249 mL
60 mM 0.1542 mL 0.7708 mL 1.5416 mL 3.8541 mL
80 mM 0.1156 mL 0.5781 mL 1.1562 mL 2.8906 mL
100 mM 0.0925 mL 0.4625 mL 0.9250 mL 2.3125 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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D-Serine-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D-Serine-d31414348-52-9(R)-Serine-d3Isotope-Labeled CompoundsInhibitorinhibitorinhibit

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