2. Membrane Transporter/Ion Channel Neuronal Signaling Metabolic Enzyme/Protease
  3. iGluR Endogenous Metabolite
  4. D-Serine

D-Serine  (Synonyms: (R)-Serine)

Cat. No.: HY-100808 Purity: ≥98.0%
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D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration.

For research use only. We do not sell to patients.

D-Serine Chemical Structure

D-Serine Chemical Structure

CAS No. : 312-84-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 61 In-stock
Solution
10 mM * 1 mL in Water USD 61 In-stock
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5 g USD 77 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of D-Serine:

D-Serine Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE D-Serine

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AMPA Receptor NMDA Receptor Kainate Receptor

  • Biological Activity

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Description

D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration[1][2].

IC50 & Target

NMDA Receptor

 

Human Endogenous Metabolite

 

In Vitro

(R)-Serine is synthesized from L-Ser by serine racemase (SR) and degraded by D-amino acid oxidase (DAAO) and SR. Distribution of D-Ser and NMDAR as determined by chemical measurement and immunohistochemistry supports D-Ser as an endogenous coagonist acting on the glycine modulatory site of the NR1 subunits of the NMDAR[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

D-Serine Related Antibodies
In Vivo

(R)-Serine (10 g/L; p.o.; throughout 8 weeks) regulates HFD induced weight gain[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Four week old male C57Bl/6 mice
Dosage: 10 g/L
Administration: Oral administration (drinking water supplemented with 10 g/l D-serine); throughout 8 weeks
Result: Showed strongly reduced weight gain during the first week of supplementation with paralleled weight gain to HFD fed mice, but no catch up thereafter.
Molecular Weight

105.09

Formula

C3H7NO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N[C@H](CO)C(O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (475.78 mM)

Methanol : < 1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 9.5157 mL 47.5783 mL 95.1565 mL
5 mM 1.9031 mL 9.5157 mL 19.0313 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (475.78 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (245 KB) HNMR (83 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 9.5157 mL 47.5783 mL 95.1565 mL 237.8913 mL
5 mM 1.9031 mL 9.5157 mL 19.0313 mL 47.5783 mL
10 mM 0.9516 mL 4.7578 mL 9.5157 mL 23.7891 mL
15 mM 0.6344 mL 3.1719 mL 6.3438 mL 15.8594 mL
20 mM 0.4758 mL 2.3789 mL 4.7578 mL 11.8946 mL
25 mM 0.3806 mL 1.9031 mL 3.8063 mL 9.5157 mL
30 mM 0.3172 mL 1.5859 mL 3.1719 mL 7.9297 mL
40 mM 0.2379 mL 1.1895 mL 2.3789 mL 5.9473 mL
50 mM 0.1903 mL 0.9516 mL 1.9031 mL 4.7578 mL
60 mM 0.1586 mL 0.7930 mL 1.5859 mL 3.9649 mL
80 mM 0.1189 mL 0.5947 mL 1.1895 mL 2.9736 mL
100 mM 0.0952 mL 0.4758 mL 0.9516 mL 2.3789 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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D-Serine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D-Serine312-84-5(R)-SerineiGluREndogenous MetaboliteIonotropic glutamate receptorsInhibitorinhibitorinhibit

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