2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. Estrogen receptor α antagonist 1

Estrogen receptor α antagonist 1 (compound 35) is a highly selective antagonist of estrogen receptor α, with IC50s of 0.02, 6.55 and 7.73 μM for estrogen receptor α, estrogen receptor β and MCF-7 cells, respectively. Estrogen receptor α antagonist 1 can be used for the research of cancer.

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Estrogen receptor α antagonist 1 Chemical Structure

Estrogen receptor α antagonist 1 Chemical Structure

CAS No. : 2580941-45-1

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Estrogen receptor α antagonist 1 Related Antibodies

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Description

Estrogen receptor α antagonist 1 (compound 35) is a highly selective antagonist of estrogen receptor α, with IC50s of 0.02, 6.55 and 7.73 μM for estrogen receptor α, estrogen receptor β and MCF-7 cells, respectively. Estrogen receptor α antagonist 1 can be used for the research of cancer[1].

IC50 & Target

IC50: 0.02 μM (estrogen receptor α), 6.55 μM (estrogen receptor β), 7.73 μM (MCF-7 cells)[1]
Cellular Effect
Cell Line Type Value Description References
MCF7 IC50
7.73 μM
Compound: 35
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability after 72 hrs by MTT assay
[PMID: 31987694]
In Vitro

Estrogen receptor α antagonist 1 (compound 35) (1 nM-100 μM; 72 h) selectively inhibits estrogen receptor α, estrogen receptor β and MCF-7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Estrogen receptor α antagonist 1 Related Antibodies

Cell Viability Assay[1]

Cell Line: MCF-7 cells
Concentration: 1 nM-100 μM
Incubation Time: 72 hours
Result: Exhibited IC50s of 0.02, 6.55 and 7.73 μM for estrogen receptor α, estrogen receptor β and MCF-7 cells, respectively at 72 hours.
Molecular Weight

452.54

Formula

C26H32N2O5
CAS No.
SMILES

O=C(C1=C(N)OC2=C(C=CC(O)=C2)C1C3=CC=C(OCCN4CCCC4)C=C3)OCCCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Estrogen receptor α antagonist 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Estrogen receptor α antagonist 12580941-45-1Estrogen receptor α antagonist1Estrogen receptor α antagonist-1Estrogen Receptor/ERRisoform selectivitysubtype selectivitybenzopyrananticanceranti-proliferativeInhibitorinhibitorinhibit

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