1. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Autophagy
  2. EGFR Autophagy
  3. Gefitinib-d6

Gefitinib-d6  (Synonyms: ZD1839-d6)

Cat. No.: HY-50895S1 Purity: ≥98.0%
COA Handling Instructions

Gefitinib-d6 is the deuterium labeled Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].

For research use only. We do not sell to patients.

Gefitinib-d<sub>6</sub> Chemical Structure

Gefitinib-d6 Chemical Structure

CAS No. : 1228664-49-0

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1 mg USD 558 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Gefitinib-d6:

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Description

Gefitinib-d6 is the deuterium labeled Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

452.94

Formula

C22H18D6ClFN4O3

CAS No.
Unlabeled CAS

184475-35-2

Appearance

Solid

Color

White to off-white

SMILES

COC1=CC2=C(C=C1OC([2H])(C([2H])(C([2H])(N3CCOCC3)[2H])[2H])[2H])C(NC4=CC=C(C(Cl)=C4)F)=NC=N2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMF : ≥ 20 mg/mL (44.16 mM)

DMSO : ≥ 20 mg/mL (44.16 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF : ≥ 20 mg/mL (44.16 mM)

DMSO : ≥ 20 mg/mL (44.16 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO:PBS (pH 7.2) (1:1) : ≥ 0.5 mg/mL (1.10 mM)

Ethanol : ≥ 0.3 mg/mL (0.66 mM)

Ethanol : ≥ 0.3 mg/mL (0.66 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2078 mL 11.0390 mL 22.0780 mL
5 mM 0.4416 mL 2.2078 mL 4.4156 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO:PBS (pH 7.2) (1:1) / DMF / DMSO / DMF / DMSO 1 mM 2.2078 mL 11.0390 mL 22.0780 mL 55.1949 mL
DMF / DMSO / DMF / DMSO 5 mM 0.4416 mL 2.2078 mL 4.4156 mL 11.0390 mL
10 mM 0.2208 mL 1.1039 mL 2.2078 mL 5.5195 mL
15 mM 0.1472 mL 0.7359 mL 1.4719 mL 3.6797 mL
20 mM 0.1104 mL 0.5519 mL 1.1039 mL 2.7597 mL
25 mM 0.0883 mL 0.4416 mL 0.8831 mL 2.2078 mL
30 mM 0.0736 mL 0.3680 mL 0.7359 mL 1.8398 mL
40 mM 0.0552 mL 0.2760 mL 0.5519 mL 1.3799 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Gefitinib-d6
Cat. No.:
HY-50895S1
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