Pde2a - phosphodiesterase 2A, cGMP-stimulated Gene

Mus musculus

Also known as cGSPDE; CGS-PDE

Gene ID: 207728 | Gene type: protein coding

About Pde2a

Chromosome 7: 101,060,093-101,162,026 forward strand.GRCm39:CM001000.3

This gene has 1 transcript (splice variant). Broad expression in adrenal adult (RPKM 43.4), cortex adult (RPKM 43.1) and 24 other tissues.

Summary

Enables several functions, including 3',5'-cyclic-nucleotide phosphodiesterase activity; GAF domain binding activity; and cyclic nucleotide binding activity. Involved in several processes, including cGMP catabolic process; cyclic-nucleotide-mediated signaling; and negative regulation of intracellular signal transduction. Acts upstream of or within cellular response to lipopolysaccharide; circulatory system development; and regulation of nitric oxide mediated signal transduction. Located in several cellular components, including mitochondrion; perinuclear region of cytoplasm; and presynaptic membrane. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system; nervous system; and sensory organ. Orthologous to human PDE2A (phosphodiesterase 2A). [provided by Alliance of Genome Resources, Apr 2022]

Pde2a Products(5)

mRNA	Protein	Name
NM_001008548.5	NP_001008548.1	cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3
NM_001143848.3	NP_001137320.1	cGMP-dependent 3',5'-cyclic phosphodiesterase isoform 6
NM_001243757.2	NP_001230686.1	cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A1
NM_001143849.3	NP_001137321.1	cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A2 precursor
NM_001243758.2	NP_001230687.1	cGMP-dependent 3',5'-cyclic phosphodiesterase isoform 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	IDA IDA: Inferred from direct assay	15210692	MGI
enables 3',5'-cyclic-AMP phosphodiesterase activity	IMP IMP: Inferred from mutant phenotype	21724846	MGI
enables 3',5'-cyclic-GMP phosphodiesterase activity	IMP IMP: Inferred from mutant phenotype	21724846	MGI
enables GAF domain binding	IDA IDA: Inferred from direct assay	12271124	MGI
enables cAMP binding	IMP IMP: Inferred from mutant phenotype	15210692	MGI
enables cGMP binding	IDA IDA: Inferred from direct assay	12271124	MGI
enables cGMP binding	IMP IMP: Inferred from mutant phenotype	15210692	MGI
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	12271124	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within aorta development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
involved in cAMP-mediated signaling	IDA IDA: Inferred from direct assay	15210692	MGI
involved in cGMP catabolic process	IMP IMP: Inferred from mutant phenotype	19632989	MGI
involved in cGMP-mediated signaling	IDA IDA: Inferred from direct assay	15210692	MGI
acts upstream of or within cardiac septum development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	21571906	MGI
involved in cellular response to mechanical stimulus	IDA IDA: Inferred from direct assay	21571906	MGI
acts upstream of or within coronary vasculature development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
acts upstream of or within heart valve development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
involved in intracellular signal transduction	IMP IMP: Inferred from mutant phenotype	28463107	MGI
involved in negative regulation of cAMP-mediated signaling	IMP IMP: Inferred from mutant phenotype	21571906	MGI
involved in negative regulation of cGMP-mediated signaling	IMP IMP: Inferred from mutant phenotype	21724846	MGI
involved in negative regulation of oxidative phosphorylation	IMP IMP: Inferred from mutant phenotype	21724846	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	21571906	MGI
involved in positive regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	21571906	MGI
involved in regulation of mitochondrion organization	IMP IMP: Inferred from mutant phenotype	28463107	MGI
acts upstream of or within regulation of nitric oxide mediated signal transduction	IGI IGI: Inferred from genetic interaction	16150726	MGI
acts upstream of or within ventricular septum development	IMP IMP: Inferred from mutant phenotype	25807483	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	19632989	MGI
located in axon	IDA IDA: Inferred from direct assay	8586960	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	19506089	MGI
located in cytosol	IDA IDA: Inferred from direct assay	17329248	MGI
located in dendrite	IDA IDA: Inferred from direct assay	8586960	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	19632989	MGI
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	28463107	MGI
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	21724846	MGI
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	28463107	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	28463107	MGI
located in nucleus	IDA IDA: Inferred from direct assay	19632989	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	19632989	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	19632989	MGI
located in presynaptic membrane	IDA IDA: Inferred from direct assay	19506089	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pde2a Protein Structure

GAF

PDEase_I

0
200
400
600
800
939 a.a.

Protein Preferred Names

Protein Names

cGMP-dependent 3',5'-cyclic phosphodiesterase

cyclic GMP-stimulated phosphodiesterase

Related Agents

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112831	Osoresnontrine	Inhibitor	99.88%	Phase 2
HY-111371	PF-05180999	Inhibitor	99.97%	Phase 1
HY-103493	TAK-915	Inhibitor	99.74%	Phase 1

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-102050	PF-05085727	Inhibitor	99.60%	Unkown
HY-132993	Hcyb1	Inhibitor	98.20%	Unkown
HY-112704	PDE5-IN-2	Inhibitor	/	Unkown
HY-120710	DNS-8254	Inhibitor	/	Unkown
HY-142660	PDE2A-IN-1	Inhibitor	/	Unkown
HY-RS10213	PDE2A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10214	Pde2a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10215	Pde2a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-124173	PF-06815189	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pde2a	NCBI	NCBI:5138

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