1. Gene
  2. PDE2A - phosphodiesterase 2A Gene

PDE2A - phosphodiesterase 2A Gene

Homo sapiens

Also known as PDE2A1; PED2A4; cGSPDE; CGS-PDE; IDDPADS

Gene ID: 5138 | Gene type: protein coding

About PDE2A

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:72,576,141-72,674,422 (from NCBI)

This gene has 27 transcripts (splice variants), 215 orthologues, 20 paralogues and is associated with 2 phenotypes. Broad expression in spleen (RPKM 45.0), brain (RPKM 27.8) and 14 other tissues.

Summary

Enables several functions, including 3',5'-cyclic-nucleotide phosphodiesterase activity; anion binding activity; and metal ion binding activity. Involved in several processes, including cellular response to organic cyclic compound; cyclic-nucleotide-mediated signaling; and regulation of vascular permeability. Located in several cellular components, including cytosol; mitochondrial membrane; and perinuclear region of cytoplasm. Colocalizes with plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

PDE2A Products(5)

mRNA Protein Name
NM_001146209.3 NP_001139681.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A4
NM_002599.5 NP_002590.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3
NM_001243784.2 NP_001230713.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A1
XM_005274040.4 XP_005274097.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1
NM_001143839.4 NP_001137311.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A2 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity IDA
IDA: Inferred from direct assay
17329248 GOA
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
IDA: Inferred from direct assay
9210593 GOA
enables 3',5'-cyclic-GMP phosphodiesterase activity IDA
IDA: Inferred from direct assay
9210593 GOA
enables TPR domain binding IPI
IPI: Inferred from physical interaction
17329248 GOA
enables cAMP binding IMP
IMP: Inferred from mutant phenotype
15938621 GOA
enables cGMP binding IDA
IDA: Inferred from direct assay
17329248 GOA
enables cGMP binding IMP
IMP: Inferred from mutant phenotype
15938621 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
19828435 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
15938621 GOA
enables phosphate ion binding IDA
IDA: Inferred from direct assay
15938621 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17329248 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
19828435 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
15938621 GOA
Biological Process GO Annotation Evidence Reference Source
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
17329248 GOA
involved in cAMP-mediated signaling IMP
IMP: Inferred from mutant phenotype
17704206 GOA
involved in cGMP catabolic process IDA
IDA: Inferred from direct assay
19828435 GOA
involved in cGMP-mediated signaling IMP
IMP: Inferred from mutant phenotype
17704206 GOA
involved in cellular response to 2,3,7,8-tetrachlorodibenzodioxine IDA
IDA: Inferred from direct assay
17329248 GOA
involved in cellular response to cAMP IDA
IDA: Inferred from direct assay
17329248 GOA
involved in cellular response to cGMP IDA
IDA: Inferred from direct assay
17704206 GOA
involved in cellular response to granulocyte macrophage colony-stimulating factor stimulus IDA
IDA: Inferred from direct assay
14687666 GOA
involved in cellular response to macrophage colony-stimulating factor stimulus IDA
IDA: Inferred from direct assay
14687666 GOA
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
17704206 GOA
involved in cellular response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
14687666 GOA
involved in monocyte differentiation IEP
IEP: Inferred from expression pattern
14687666 GOA
involved in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
19252089 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17329248 GOA
involved in negative regulation of vascular permeability IMP
IMP: Inferred from mutant phenotype
17704206 GOA
involved in positive regulation of vascular permeability IMP
IMP: Inferred from mutant phenotype
17704206 GOA
involved in regulation of cAMP-mediated signaling IMP
IMP: Inferred from mutant phenotype
15938621 GOA
involved in regulation of cGMP-mediated signaling IMP
IMP: Inferred from mutant phenotype
15938621 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10375378 GOA
located in cytosol IDA
IDA: Inferred from direct assay
17329248 GOA
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
28463107 GOA
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
28463107 GOA
located in nucleus IDA
IDA: Inferred from direct assay
10375378 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
10375378 GOA
colocalizes with plasma membrane IDA
IDA: Inferred from direct assay
17329248 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
19252089 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDE2A Protein Structure

GAF

GAF: GAF domain (248 - 367)

GAF

GAF: GAF domain (409 - 548)

PDEase_I

PDEase_I: 3'5'-cyclic nucleotide phosphodiesterase (655 - 892)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 941 a.a.
Protein Preferred Names Protein Names

cGMP-dependent 3',5'-cyclic phosphodiesterase

cGMP-stimulated phosphodiesterase 1

cGMP-stimulated phosphodiesterase 2

cGMP-stimulated phosphodiesterase 4

cyclic GMP-stimulated phosphodiesterase

phosphodiesterase 2A, cGMP-stimulated

PDE2A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PDE2A O00408 AIP Homo sapiens O00170 17329248
Intra
PDE2A O00408 AIP Homo sapiens O00170 17329248
Intra
PDE2A O00408 AIP Homo sapiens O00170 17329248
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PDE2A Proteins

Cat. No. Product Name Accession Purity
HY-P74647 PDE2A Protein, Human (sf9, His) O00408 (E215-H900) ≥95%

PDE2A Antibodies

Cat. No. Product Name Application Reactivity
HY-P83244 PDE2A Antibody (YA2989) WB Human, Mouse, Rat

Related Diseases

Diseases Alias
Scrotum Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Scrotum

Scrotal Squamous Cell Carcinoma

Transient Global Amnesia

Amnesia, Transient Global

Retinal Degeneration

Degeneration Of Retina

Paroxysmal Dystonia

Paroxysmal Dyskinesia

Pxd - [Paroxysmal Dyskinesia]

Convulsions, Familial Infantile, With Paroxysmal Choreoathetosis

ICCA

Icca Syndrome

Infantile Convulsions And Choreoathetosis

Infantile Convulsions And Paroxysmal Choreoathetosis, Familial

Pkd/Ic

Familial Infantile Convulsions And Paroxysmal Choreoathetosis

Paroxysmal Kinesigenic Dyskinesia With Infantile Convulsions

Convulsions, Infantile, With Paroxysmal Choreoathetosis, Familial

Paroxysmal Kinesigenic Dyskinesia And Infantile Convulsions

Icca Syndrome Paroxysmal Kinesigenic Dyskinesia With Infantile Convulsions

Dyskinetic Syndrome

Paroxysmal Dyskinesia

Paroxysmal Choreoathetosis

Paroxysmal Dystonic Choreoathetosis

Paroxysmal Dyskinesias

Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1

Choreatic Disease

Chorea

Hereditary Chorea

Intellectual Developmental Disorder With Paroxysmal Dyskinesia Or Seizures

IDDPADS

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta PDE2A VGNC VGNC:75912
Canis familiaris PDE2A VGNC VGNC:44351
Felis catus PDE2A VGNC VGNC:68755
Bos taurus PDE2A VGNC VGNC:32674
Mus musculus PDE2A MGD MGI:2446107
Rattus norvegicus PDE2A RGD RGD:620965
Others PDE2A NCBI