ANXA3 - annexin A3 Gene

Homo sapiens

Also known as ANX3

Gene ID: 306 | Gene type: protein coding

About ANXA3

Cytogenetic location: 4q21.21 Genomic coordinates (GRCh38): 4:78,551,770-78,610,447 (from NCBI)

This gene has 10 transcripts (splice variants), 233 orthologues and 12 paralogues. Broad expression in bone marrow (RPKM 99.1), lung (RPKM 76.4) and 15 other tissues.

Summary

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phopholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation. [provided by RefSeq, Jul 2008]

ANXA3 Products(1)

mRNA	Protein	Name
NM_005139.3	NP_005130.1	annexin A3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium-dependent phospholipid binding	IDA IDA: Inferred from direct assay	2138016	GOA
enables calcium-dependent protein binding	IPI IPI: Inferred from physical interaction	15226301	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in defense response to bacterium	IDA IDA: Inferred from direct assay	9497492	GOA
involved in neutrophil degranulation	IDA IDA: Inferred from direct assay	9550422	GOA
involved in phagocytosis	IDA IDA: Inferred from direct assay	9497492	GOA
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	16236264	GOA
involved in positive regulation of angiogenesis	IDA IDA: Inferred from direct assay	16236264	GOA
involved in positive regulation of endothelial cell migration	IDA IDA: Inferred from direct assay	16236264	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17205602	GOA
located in membrane	IDA IDA: Inferred from direct assay	17205602	GOA
located in phagocytic vesicle membrane	IDA IDA: Inferred from direct assay	7526843	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	7526843	GOA
located in specific granule	IDA IDA: Inferred from direct assay	7526843	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANXA3 Protein Structure

Annexin

0
100
200
300
323 a.a.

Protein Preferred Names

Protein Names

annexin A3

35-alpha calcimedin

Recombinant ANXA3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7516	Annexin A3/ANXA3 Protein, Human	P12429 (M1-D323)	≥95%

Related Diseases

Diseases

Alias

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00763	ANXA3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ANXA3	MGD	MGI:1201378
Felis catus	ANXA3	VGNC	VGNC:67699
Bos taurus	ANXA3	VGNC	VGNC:25965
Canis familiaris	ANXA3	VGNC	VGNC:37940
Rattus norvegicus	ANXA3	RGD	RGD:2119
Macaca mulatta	ANXA3	VGNC	VGNC:69948
Others	ANXA3	NCBI

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