2. Gene
  3. Adam8 - ADAM metallopeptidase domain 8 Gene

Adam8 - ADAM metallopeptidase domain 8 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as RGD1566394

Gene ID: 499285 | Gene type: protein coding

About Adam8

Primary_assembly 1: 194,770,060-194,788,801 reverse strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 245 orthologues, 29 paralogues and is associated with 7 phenotypes. Biased expression in Lung (RPKM 68.), Spleen (RPKM 32.8) and 8 other tissues.

Summary

Predicted to enable cell adhesion molecule binding activity; metal ion binding activity; and metallopeptidase activity. Predicted to be involved in several processes, including leukocyte migration; positive regulation of leukocyte migration; and positive regulation of macromolecule metabolic process. Predicted to act upstream of or within cell-cell adhesion. Predicted to be located in several cellular components, including cell surface; cytoplasmic vesicle; and podosome. Predicted to be integral component of plasma membrane. Predicted to be part of alpha9-beta1 integrin-ADAM8 complex. Orthologous to human ADAM8 (ADAM metallopeptidase domain 8). [provided by Alliance of Genome Resources, Apr 2022]

Adam8 Products(8)

mRNA Protein Name
XM_006230499.4 XP_006230561.1 disintegrin and metalloproteinase domain-containing protein 8 isoform X1
XM_006230501.4 XP_006230563.1 disintegrin and metalloproteinase domain-containing protein 8 isoform X7
XM_017590243.2 XP_017445732.1 disintegrin and metalloproteinase domain-containing protein 8 isoform X6
XM_039101260.1 XP_038957188.1 disintegrin and metalloproteinase domain-containing protein 8 isoform X4
XM_039101261.1 XP_038957189.1 disintegrin and metalloproteinase domain-containing protein 8 isoform X5
XM_039101259.1 XP_038957187.1 disintegrin and metalloproteinase domain-containing protein 8 isoform X3
XM_006230500.4 XP_006230562.1 disintegrin and metalloproteinase domain-containing protein 8 isoform X2
XM_039101262.1 XP_038957190.1 disintegrin and metalloproteinase domain-containing protein 8 isoform X8

Adam8 Protein Structure

Pep_M12B_propep

Pep_M12B_propep: pfam01562 (27 - 151)

Reprolysin

Reprolysin: pfam01421 (195 - 394)

DISIN

DISIN: smart00050 (411 - 485)

ACR

ACR: smart00608 (487 - 606)

PHA03247

PHA03247: cl33720 (735 - 863)

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  • 868 a.a.
Protein Preferred Names Protein Names

disintegrin and metalloproteinase domain-containing protein 8

a disintegrin and metallopeptidase domain 8

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-120852 JG26 Inhibitor 98.01% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adam8 NCBI NCBI:101
Mus musculus Adam8 NCBI NCBI:11501
Macaca mulatta Adam8 NCBI NCBI:100428452