Adam8 - a disintegrin and metallopeptidase domain 8 Gene

Mus musculus

Also known as MS2; CD156; ADAM 8; CD156a; E430039A18Rik

Gene ID: 11501 | Gene type: protein coding

About Adam8

Chromosome 7: 139,558,845-139,572,475 reverse strand.GRCm39:CM001000.3

This gene has 8 transcripts (splice variants), 245 orthologues, 35 paralogues and is associated with 8 phenotypes. Broad expression in ovary adult (RPKM 21.), thymus adult (RPKM 6.6) and 19 other tissues.

Summary

This gene encodes a member of the Adam family of proteins that contain the disintegrin and metalloprotease domains. The encoded protein is localized to the cell surface, where it is involved in the remodeling of extracellular matrix and cell migration. Mice lacking the encoded protein display persistent inflammation upon treatment with allergens. Alternative splicing of this gene results in multiple variants. [provided by RefSeq, Mar 2015]

Adam8 Products(2)

mRNA	Protein	Name
NM_001291066.2	NP_001277995.1	disintegrin and metalloproteinase domain-containing protein 8 isoform 2 precursor
NM_007403.3	NP_031429.1	disintegrin and metalloproteinase domain-containing protein 8 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	12372841	MGI
enables cell adhesion molecule binding	IPI IPI: Inferred from physical interaction	12135759	MGI
enables metallopeptidase activity	IDA IDA: Inferred from direct assay	12135759	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12135759	MGI
enables zinc ion binding	IDA IDA: Inferred from direct assay	12135759	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in angiogenesis	IDA IDA: Inferred from direct assay	19003792	MGI
involved in canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	20683884	MGI
involved in cell morphogenesis	IMP IMP: Inferred from mutant phenotype	11341326	MGI
acts upstream of or within cell-cell adhesion	IDA IDA: Inferred from direct assay	12372841	MGI
involved in leukocyte migration involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	20194813	MGI
involved in lymphocyte chemotaxis	IDA IDA: Inferred from direct assay	20856819	MGI
involved in negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	14761956	MGI
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	20683884	MGI
involved in positive regulation of T cell differentiation in thymus	IDA IDA: Inferred from direct assay	20856819	MGI
involved in positive regulation of T cell migration	IMP IMP: Inferred from mutant phenotype	20194813	MGI
involved in positive regulation of acute inflammatory response	IMP IMP: Inferred from mutant phenotype	21268008	MGI
involved in positive regulation of bone resorption	IDA IDA: Inferred from direct assay	11341326	MGI
involved in positive regulation of bone resorption	IMP IMP: Inferred from mutant phenotype	20683884	MGI
involved in positive regulation of cell adhesion	IDA IDA: Inferred from direct assay	12372841	MGI
involved in positive regulation of cellular extravasation	IMP IMP: Inferred from mutant phenotype	20194813	MGI
involved in positive regulation of eosinophil migration	IMP IMP: Inferred from mutant phenotype	20194813	MGI
involved in positive regulation of epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	34615811	MGI
involved in positive regulation of fibronectin-dependent thymocyte migration	IMP IMP: Inferred from mutant phenotype	20856819	MGI
involved in positive regulation of inflammatory response	IDA IDA: Inferred from direct assay	19397475	MGI
involved in positive regulation of innate immune response	IDA IDA: Inferred from direct assay	20683884	MGI
involved in positive regulation of membrane protein ectodomain proteolysis	IDA IDA: Inferred from direct assay	14761956	MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	20683884	MGI
involved in positive regulation of thymocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	20856819	MGI
involved in positive regulation of tumor necrosis factor (ligand) superfamily member 11 production	IMP IMP: Inferred from mutant phenotype	20683884	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of alpha9-beta1 integrin-ADAM8 complex	IDA IDA: Inferred from direct assay	16995821	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	12372841	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Adam8 Protein Structure

Pep_M12B_propep

Reprolysin

DISIN

ACR

PHA03247

0
200
400
600
825 a.a.

Protein Preferred Names

Protein Names

disintegrin and metalloproteinase domain-containing protein 8

a disintegrin and metalloprotease domain 8	cell surface antigen MS2
macrophage cysteine-rich glycoprotein

Recombinant Adam8 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77558	ADAM8 Protein, Mouse (HEK293, His)	Q05910 (P17-S658)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120852	JG26	Inhibitor	98.01%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adam8	NCBI	NCBI:101
Macaca mulatta	Adam8	NCBI	NCBI:100428452

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