2. Gene
  3. TEC - tec protein tyrosine kinase Gene

TEC - tec protein tyrosine kinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as PSCTK4

Gene ID: 7006 | Gene type: protein coding

About TEC

Summary

The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of Cytokine Receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and Integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome. [provided by RefSeq, Jul 2008]

TEC Products(1)

mRNA Protein Name
NM_003215.3 NP_003206.2 tyrosine-protein kinase Tec
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables non-membrane spanning protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
10518561 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
8892607 GOA
Biological Process GO Annotation Evidence Reference Source
involved in B cell receptor signaling pathway IDA
IDA: Inferred from direct assay
10518561 GOA
involved in integrin-mediated signaling pathway IDA
IDA: Inferred from direct assay
9652744 GOA
involved in regulation of platelet activation IDA
IDA: Inferred from direct assay
9299487 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoskeleton IDA
IDA: Inferred from direct assay
9299487 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tyrosine-protein kinase Tec

TEC Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TEC P42680 MET Homo sapiens P08581
FPS
24728074
Intra
TEC P42680 GAB1 Homo sapiens Q13480
FPS
24728074
Cross: Cross-species interaction Intra: Intraspecies interaction

TEC Antibodies

Cat. No. Product Name Application Reactivity
HY-P82436 Tec Antibody (YA2181) WB, ICC/IF Human

Related Agents

Pre-clinical Phase
Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-130665 TL12-186 Inhibitor 99.63% Unkown
HY-80002 BMX-IN-1 Inhibitor 99.04% Unkown
HY-18010 PCI 29732 Inhibitor 99.86% Unkown
HY-N11772 Mutanocyclin Inhibitor 99.94% Unkown
HY-149051 BGB-8035 Inhibitor 99.00% Unkown
HY-109143B (R)-Elsubrutinib Inhibitor ≥98.0% Unkown
HY-117900 PF-06250112 Inhibitor / Unkown
HY-145373 BMS-986143 Inhibitor / Unkown
HY-117900A (Rac)-PF-06250112 / Unkown
HY-123541 Tec-IN-6 Inhibitor / Unkown
HY-124827 Tec-IN-1 Inhibitor / Unkown
HY-142932 BTK-IN-6 Inhibitor / Unkown
HY-RS14346 TEC Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TEC NCBI NCBI:482140
Macaca fascicularis TEC NCBI NCBI:102134473
Mus musculus TEC NCBI NCBI:21682