2. Gene
  3. Pik3cb - phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Gene

Pik3cb - phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as p110beta; 1110001J02Rik

Gene ID: 74769 | Gene type: protein coding

About Pik3cb

Chromosome 9: 98,918,707-99,022,674 reverse strand.GRCm39:CM001002.3

This gene has 3 transcripts (splice variants), 214 orthologues, 9 paralogues and is associated with 48 phenotypes. Ubiquitous expression in placenta adult (RPKM 11.2), subcutaneous fat pad adult (RPKM 5.) and 28 other tissues.

Summary

Enables 1-phosphatidylinositol-3-kinase activity and Insulin Receptor substrate binding activity. Involved in several processes, including phosphatidylinositol 3-kinase signaling; regulation of intracellular signal transduction; and response to ischemia. Acts upstream of or within several processes, including angiogenesis involved in wound healing; embryonic cleavage; and homophilic cell adhesion via plasma membrane adhesion molecules. Located in nucleus. Is expressed in several structures, including early embryo; genitourinary system; liver; respiratory system; and spleen. Human ortholog(s) of this gene implicated in glioblastoma; prostate adenocarcinoma; prostate cancer; and type 2 diabetes mellitus. Orthologous to human PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta). [provided by Alliance of Genome Resources, Apr 2022]

Pik3cb Products(1)

mRNA Protein Name
NM_029094.3 NP_083370.2 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

Pik3cb Protein Structure

PI3K_p85B

PI3K_p85B: smart00143 (34 - 111)

PI3K_rbd

PI3K_rbd: smart00144 (173 - 281)

C2_PI3K_class_I_beta_delta

C2_PI3K_class_I_beta_delta: cd08693 (317 - 494)

PI3Ka_I

PI3Ka_I: cd00872 (525 - 695)

PI3Kc_IA_beta

PI3Kc_IA_beta: cd05173 (699 - 1060)

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  • 1064 a.a.
Protein Preferred Names Protein Names

phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

PI3-kinase subunit beta

PI3K-beta

PI3Kbeta

phosphatidylinositol 3-kinase, catalytic, beta polypeptide

phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta

ptdIns-3-kinase subunit beta

ptdIns-3-kinase subunit p110-beta

serine/threonine protein kinase PIK3CB

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-126077 MTI-31 Inhibitor 99.98% Unkown
HY-RS10526 PIK3CB Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS10527 Pik3cb Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS10528 PIK3CB Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pik3cb NCBI NCBI:5291