HAIYPRH hydrochloride

Name: HAIYPRH hydrochloride
Brand: MedChemExpress
SKU: HY-P2314
Rating: 4.5 (1 reviews)

Cat. No.: HY-P2314 Purity: 99.97%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

HAIYPRH hydrochloride, a targeting ligand, can specially bind to transferrin receptor (TfR). HAIYPRH hydrochloride can mediate the transport of nanocarriers across the blood-brain barrier.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

HAIYPRH hydrochloride Chemical Structure

Size	Price	Stock	Quantity
5 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

HAIYPRH hydrochloride, a targeting ligand, can specially bind to transferrin receptor (TfR). HAIYPRH hydrochloride can mediate the transport of nanocarriers across the blood-brain barrier^[1].

In Vitro

HAIYPRH hydrochloride (T7) is conjugated to liposomes for ischemic stroke targeting treatment of a novel neuroprotectant (HY-100456: ZL006)^[2].
HAIYPRH hydrochloride is a heptapeptide that can be used to target gliomas^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

HAIYPRH hydrochloride, a transferrin receptor-specific peptide, is chosen as the ligand to target the co-delivery system to the tumor cells expressing transferrin receptors. HAIYPRH-modified co-delivery system shows higher efficiency in cellular uptake and gene expression than unmodified co-delivery system in U87 MG cells, and accumulated in tumor more efficiently in vivo^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

929.46

Formula

C₄₁H₆₁ClN₁₄O₉

Appearance

Solid

Color

White to off-white

Sequence Shortening

HAIYPRH

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light, under nitrogen

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility

In Vitro:

H₂O : ≥ 100 mg/mL (107.59 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0759 mL	5.3795 mL	10.7589 mL
5 mM	0.2152 mL	1.0759 mL	2.1518 mL
10 mM	0.1076 mL	0.5379 mL	1.0759 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.97%

Select Batch:

Data Sheet (278 KB) SDS (252 KB)

COA (258 KB) RP-HPLC (264 KB) Elemental Analysis Report (118 KB)

Handling Instructions (2659 KB)

References

[1]. Liu S, et al. Gene and doxorubicin co-delivery system for targeting therapy of glioma. Biomaterials. 2012;33(19):4907‐4916. [Content Brief]

[2]. Wang Z, et al. Enhanced anti-ischemic stroke of ZL006 by T7-conjugated PEGylated liposomes drug delivery system. Sci Rep. 2015;5:12651. Published 2015 Jul 29. [Content Brief]

[3]. Ziyang Zhu, et al. Goat milk-derived exosomes Endowed with Radioactive and Targeting Properties: potential to provide PET/CT monitoring for exosomes-based drug delivery system in gliomas therapy. J Nucl Med May 1, 2020 vol. 61.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.0759 mL	5.3795 mL	10.7589 mL	26.8973 mL
	5 mM	0.2152 mL	1.0759 mL	2.1518 mL	5.3795 mL
	10 mM	0.1076 mL	0.5379 mL	1.0759 mL	2.6897 mL
	15 mM	0.0717 mL	0.3586 mL	0.7173 mL	1.7932 mL
	20 mM	0.0538 mL	0.2690 mL	0.5379 mL	1.3449 mL
	25 mM	0.0430 mL	0.2152 mL	0.4304 mL	1.0759 mL
	30 mM	0.0359 mL	0.1793 mL	0.3586 mL	0.8966 mL
	40 mM	0.0269 mL	0.1345 mL	0.2690 mL	0.6724 mL
	50 mM	0.0215 mL	0.1076 mL	0.2152 mL	0.5379 mL
	60 mM	0.0179 mL	0.0897 mL	0.1793 mL	0.4483 mL
	80 mM	0.0134 mL	0.0672 mL	0.1345 mL	0.3362 mL
	100 mM	0.0108 mL	0.0538 mL	0.1076 mL	0.2690 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.