2. Anti-infection
  3. RSV
  4. JNJ-8003

JNJ-8003 is a potent inhibitor of RSV Polymerase. JNJ-8003 inhibits nucleotide polymerization of RNA transcription and replication at the early stages.

For research use only. We do not sell to patients.

JNJ-8003 Chemical Structure

JNJ-8003 Chemical Structure

Size Price Stock Quantity
1 mg USD 420 In-stock
5 mg USD 1050 In-stock
10 mg USD 1680 In-stock
25 mg USD 3400 In-stock
50 mg USD 5200 Get quote
100 mg USD 7600 Get quote
200 mg   Get quote  
500 mg   Get quote  

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JNJ-8003 Related Antibodies

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Description

JNJ-8003 is a potent inhibitor of RSV Polymerase. JNJ-8003 inhibits nucleotide polymerization of RNA transcription and replication at the early stages[1].

Molecular Weight

576.51

Formula

C28H25F5N4O4
Appearance

Solid

Color

Off-white to light yellow

SMILES

CC(N=N1)=CC2=C1C(OC)=CC(C(NC[C@](C(F)(F)F)(O)C3=CC(C(C)(C)O)=C(F)C(C4=CC=C(F)C=C4)=N3)=O)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (216.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7346 mL 8.6729 mL 17.3458 mL
5 mM 0.3469 mL 1.7346 mL 3.4692 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7346 mL 8.6729 mL 17.3458 mL 43.3644 mL
5 mM 0.3469 mL 1.7346 mL 3.4692 mL 8.6729 mL
10 mM 0.1735 mL 0.8673 mL 1.7346 mL 4.3364 mL
15 mM 0.1156 mL 0.5782 mL 1.1564 mL 2.8910 mL
20 mM 0.0867 mL 0.4336 mL 0.8673 mL 2.1682 mL
25 mM 0.0694 mL 0.3469 mL 0.6938 mL 1.7346 mL
30 mM 0.0578 mL 0.2891 mL 0.5782 mL 1.4455 mL
40 mM 0.0434 mL 0.2168 mL 0.4336 mL 1.0841 mL
50 mM 0.0347 mL 0.1735 mL 0.3469 mL 0.8673 mL
60 mM 0.0289 mL 0.1445 mL 0.2891 mL 0.7227 mL
80 mM 0.0217 mL 0.1084 mL 0.2168 mL 0.5421 mL
100 mM 0.0173 mL 0.0867 mL 0.1735 mL 0.4336 mL
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JNJ-8003 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNJ-8003JNJ8003JNJ 8003RSVRespiratory syncytial virusRSV Polymerase InhibitorRespiratory syncytial virus polymeraseNon-nucleoside InhibitorInhibitorinhibitorinhibit

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