2. MAPK/ERK Pathway
  3. JNK
  4. JNK-1-IN-3

JNK-1-IN-3 (Compound 9e) is an inhibitor of JNK1 that downregulates JNK1 gene expression and inhibits the protein levels of its phosphorylated form, concurrently reducing the expression of its downstream targets, c-Jun and c-Fos, in tumors while restoring p53 activity. JNK-1-IN-3 exhibits broad-spectrum antiproliferative activity, particularly with high inhibitory activity against renal and breast cancer cell lines, demonstrating both in vivo and in vitro anticancer activity.

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JNK-1-IN-3 Chemical Structure

JNK-1-IN-3 Chemical Structure

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JNK-1-IN-3 Related Antibodies

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Description

JNK-1-IN-3 (Compound 9e) is an inhibitor of JNK1 that downregulates JNK1 gene expression and inhibits the protein levels of its phosphorylated form, concurrently reducing the expression of its downstream targets, c-Jun and c-Fos, in tumors while restoring p53 activity. JNK-1-IN-3 exhibits broad-spectrum antiproliferative activity, particularly with high inhibitory activity against renal and breast cancer cell lines, demonstrating both in vivo and in vitro anticancer activity[1].

Molecular Weight

368.36

Formula

C19H17FN4O3
SMILES

O=C(NNC1=NN=C(C2=CC=C(OC)C(OC)=C2)C=C1)C3=CC=C(F)C=C3
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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JNK-1-IN-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNK-1-IN-3JNKc-Jun N-terminal kinaseCCRF-CEMHL-60(TB)K-562MOLT-4RPMI-8226A549/ATCCHOP-62HOP-92NCI-H226NCI-H522HCT-15SF-268SNB-75LOX IMVISK-MEL-5NCI-60leukemianonsmall cell lung cancercolon cancerCNS cancermelanomaanticancer activityInhibitorinhibitorinhibit

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