2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. KRAS inhibitor-22

KRAS inhibitor-22 (compound FB9/6B9) is a potent inhibitor of K-Ras. KRAS inhibitor-22 targets to Kras 4B(G12D) and (G12C), which can be used for cancer research.

For research use only. We do not sell to patients.

KRAS inhibitor-22 Chemical Structure

KRAS inhibitor-22 Chemical Structure

CAS No. : 2042365-57-9

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KRAS inhibitor-22 Related Antibodies

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Description

KRAS inhibitor-22 (compound FB9/6B9) is a potent inhibitor of K-Ras. KRAS inhibitor-22 targets to Kras 4B(G12D) and (G12C), which can be used for cancer research[1].

In Vitro

KRAS inhibitor-22 (8 μM; 24 h) degrades K-Ras induced by 25 ng/mL EGF, in MIAPaCa-2 cells (G12C) and in L3.6pl cells (G12D)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KRAS inhibitor-22 Related Antibodies

Western Blot Analysis[1]

Cell Line: MIAPaCa-2 cells (G12C) and L3.6pl cells (G12D)
Concentration: 8 μM
Incubation Time: 7 min, 60 min, 24 h, 48 h
Result: Degraded K-Ras (G12D) in L3.6pl cells during 24 h reeatment, but insignificantly at 48 h.
Degraded K-Ras (G12C) in MIAPaCa-2 cells during 48 h.
Molecular Weight

516.87

Formula

C23H21ClF4N2O5
CAS No.
SMILES

O=C(N1C[C@H](CCC1)C(NCC(COC2=C(C(F)=CC(F)=C2F)F)=O)=O)C3=C(C=CC(Cl)=C3)OC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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KRAS inhibitor-22 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRAS inhibitor-222042365-57-9KRAS inhibitor22KRAS inhibitor 22RasKRAS (G12D)KRAS (G12C)Inhibitorinhibitorinhibit

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