2. MAPK/ERK Pathway GPCR/G Protein Cell Cycle/DNA Damage
  3. Ras PERK
  4. KRAS inhibitor-40

KRAS inhibitor-40 (Compound 41) is a KRAS inhibitor that interferes with the KRAS G12C-BRAF complex. KRAS inhibitor-40 inhibits the ERK phosphorylation of KRAS downstream signaling pathway. KRAS inhibitor-40 can inhibit the proliferation of tumor cells with different KRAS mutation types and has antitumor activity.

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KRAS inhibitor-40 Chemical Structure

KRAS inhibitor-40 Chemical Structure

CAS No. : 3059496-56-6

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KRAS inhibitor-40 Related Antibodies

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Description

KRAS inhibitor-40 (Compound 41) is a KRAS inhibitor that interferes with the KRAS G12C-BRAF complex. KRAS inhibitor-40 inhibits the ERK phosphorylation of KRAS downstream signaling pathway. KRAS inhibitor-40 can inhibit the proliferation of tumor cells with different KRAS mutation types and has antitumor activity[1].

IC50 & Target[1]

KRas G12C

 

Molecular Weight

1102.67

Formula

C53H68ClF4N9O8S
CAS No.
SMILES

O=C([C@H](F)Cl)N1CCC(C(N([C@H](C(N[C@H](C(N2N[C@H](C(OCC(C)(C)CC3=C(C4=C([C@H](C)OC)N=CC(N5CCOCC5)=C4)N6CC(F)(F)C7)=O)CCC2)=O)CC8=NC(C9=CC7C6C3=C9)=CS8)=O)C(C)C)C)=O)(F)CC1
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KRAS inhibitor-40 Related Classifications

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Keywords:

KRAS inhibitor-403059496-56-6KRAS inhibitor40KRAS inhibitor 40RasPERKProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinaseNCI-H358AGSSW620Inhibitorinhibitorinhibit

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