Kynurenic acid-d₅ (Synonyms: Quinurenic acid-d₅)

Name: Kynurenic acid-d 5
Brand: MedChemExpress
SKU: HY-100806S
Rating: 4.5 (1 reviews)

Cat. No.: HY-100806S Purity: 98.35%: FAQs
Data Sheet SDS COA Handling Instructions

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Kynurenic acid-d₅ is the deuterium labeled Kynurenic acid. Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8[1][2].

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Kynurenic acid-d₅ Chemical Structure

CAS No. : 350820-13-2

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1 mg USD 166 In-stock

Estimated Time of Arrival: December 31

5 mg USD 500 In-stock

Estimated Time of Arrival: December 31

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Based on 1 publication(s) in Google Scholar

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Kynurenic acid-d₅ Related Antibodies

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Description

Kynurenic acid-d₅ is the deuterium labeled Kynurenic acid. Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8[1][2].

IC₅₀ & Target

NMDA Receptor

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Kynurenic acid-d₅ Related Antibodies

Molecular Weight
194.20

Formula
C₁₀H₂D₅NO₃

CAS No.
350820-13-2

Unlabeled CAS
492-27-3

Appearance

Solid

Color

White to off-white

SMILES
OC1=C([2H])C(C(O)=O)=NC2=C1C([2H])=C([2H])C([2H])=C2[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder -20°C 3 years

4°C 2 years

In solvent -80°C 6 months

-20°C 1 month

Solvent & Solubility
In Vitro:

0.1 M NaOH : 12.5 mg/mL (64.37 mM; ultrasonic and adjust pH to 9 with NaOH)

0.1 M NaOH : 12.5 mg/mL (64.37 mM; ultrasonic and adjust pH to 9 with NaOH)

Preparing
Stock Solutions

Concentration Solvent Mass 1 mg 5 mg 10 mg

1 mM 5.1493 mL 25.7467 mL 51.4933 mL

5 mM 1.0299 mL 5.1493 mL 10.2987 mL

10 mM 0.5149 mL 2.5747 mL 5.1493 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.35%
Select Batch:

Data Sheet (276 KB) SDS (251 KB)
COA (252 KB) HNMR (448 KB) RP-HPLC (905 KB)
Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Wang J, et al. Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35. J Biol Chem. 2006 Aug 4;281(31):22021-8. [Content Brief]

[3]. Albuquerque EX, et al. Kynurenic acid as an antagonist of α7 nicotinic acetylcholine receptors in the brain: facts and challenges. Biochem Pharmacol. 2013 Apr 15;85(8):1027-32. [Content Brief]

[4]. Małaczewska J, et al. Effect of oral administration of kynurenic acid on the activity of the peripheral blood leukocytes in mice. Cent Eur J Immunol. 2014;39(1):6-13. [Content Brief]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Wang J, et al. Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35. J Biol Chem. 2006 Aug 4;281(31):22021-8.

[3]. Albuquerque EX, et al. Kynurenic acid as an antagonist of α7 nicotinic acetylcholine receptors in the brain: facts and challenges. Biochem Pharmacol. 2013 Apr 15;85(8):1027-32.

[4]. Małaczewska J, et al. Effect of oral administration of kynurenic acid on the activity of the peripheral blood leukocytes in mice. Cent Eur J Immunol. 2014;39(1):6-13.

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg

0.1 M NaOH / 0.1 M NaOH 1 mM 5.1493 mL 25.7467 mL 51.4933 mL 128.7333 mL

5 mM 1.0299 mL 5.1493 mL 10.2987 mL 25.7467 mL

10 mM 0.5149 mL 2.5747 mL 5.1493 mL 12.8733 mL

15 mM 0.3433 mL 1.7164 mL 3.4329 mL 8.5822 mL

20 mM 0.2575 mL 1.2873 mL 2.5747 mL 6.4367 mL

25 mM 0.2060 mL 1.0299 mL 2.0597 mL 5.1493 mL

30 mM 0.1716 mL 0.8582 mL 1.7164 mL 4.2911 mL

40 mM 0.1287 mL 0.6437 mL 1.2873 mL 3.2183 mL

50 mM 0.1030 mL 0.5149 mL 1.0299 mL 2.5747 mL

60 mM 0.0858 mL 0.4291 mL 0.8582 mL 2.1456 mL

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Kynurenic acid-d₅ Related Classifications

Isotope-Labeled Compounds

Research Area Internal Standard for Clinical Mass Spectrometry Isotope-Labeled Inhibitors Deuterium (²H, D)

Stable Isotope-Labeled Inhibitors Stable isotope-labeled inhibitors for use in in vivo cell experiments Therapeutic Drug Monitoring: TDM

Neurological Disease Inflammation/Immunology Endocrinology

Others Neuronal Signaling Membrane Transporter/Ion Channel Metabolic Enzyme/Protease Apoptosis Immunology/Inflammation GPCR/G Protein

Isotope-Labeled Compounds iGluR Endogenous Metabolite Apoptosis CXCR GPR35

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kynurenic acid-d₅350820-13-2Quinurenic acid-d₅Isotope-Labeled CompoundsiGluREndogenous MetaboliteApoptosisCXCRGPR35Ionotropic glutamate receptorsCXC chemokine receptorsC-X-C motif chemokine receptorsG Protein-Coupled Receptor 35Inhibitorinhibitorinhibit

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Size	Price	Stock	Quantity
1 mg	USD 166	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 500	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

0.1 M NaOH / 0.1 M NaOH	1 mM	5.1493 mL	25.7467 mL	51.4933 mL	128.7333 mL
	5 mM	1.0299 mL	5.1493 mL	10.2987 mL	25.7467 mL
	10 mM	0.5149 mL	2.5747 mL	5.1493 mL	12.8733 mL
	15 mM	0.3433 mL	1.7164 mL	3.4329 mL	8.5822 mL
	20 mM	0.2575 mL	1.2873 mL	2.5747 mL	6.4367 mL
	25 mM	0.2060 mL	1.0299 mL	2.0597 mL	5.1493 mL
	30 mM	0.1716 mL	0.8582 mL	1.7164 mL	4.2911 mL
	40 mM	0.1287 mL	0.6437 mL	1.2873 mL	3.2183 mL
	50 mM	0.1030 mL	0.5149 mL	1.0299 mL	2.5747 mL
	60 mM	0.0858 mL	0.4291 mL	0.8582 mL	2.1456 mL

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Kynurenic acid-d5 (Synonyms: Quinurenic acid-d5)

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Kynurenic acid-d5 Related Antibodies

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Complete Stock Solution Preparation Table

Kynurenic acid-d5 Related Classifications

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Kynurenic acid-d₅ (Synonyms: Quinurenic acid-d₅)

Other Forms of Kynurenic acid-d₅:

Kynurenic acid-d₅ Related Antibodies

Kynurenic acid-d₅ Related Antibodies

Kynurenic acid-d₅ Related Classifications