CXCR Inhibitors

CXCR

CXCR1

CXCR2

CXCR3

CXCR4

CXCR7

CXCR6

CXCR Inhibitors, Agonists, Antagonists, Activators & Modulators

Product Name	CXCR	CXCR1	CXCR2	CXCR3	CXCR4	CXCR7	CXCR6	Purity
Plerixafor					¹²⁵I-CXCL12-CXCR4, IC₅₀: 44 nM			99.90%
SB225002			¹²⁵I-IL-8-CXCR2, IC₅₀: 22 nM (in CHO cell membrane)					99.87%
AMG 487				¹²⁵I-IP10-CXCR3, IC₅₀: 8 nM ¹²⁵I-ITAC-CXCR3, IC₅₀: 8.2 nM				99.65%
Reparixin		CXCR1^wt, IC₅₀: 5.6 nM (in L1.2 cells) CXCR1^Ile43Val, IC₅₀: 80 nM (in L1.2 cells) CXCR1, IC₅₀: 1 nM (in cells)	CXCR2, IC₅₀: ∼100 nM (in cells)					99.95%
Plerixafor octahydrochloride					¹²⁵I-CXCL12-CXCR4, IC₅₀: 44 nM			99.09%
Navarixin		Cynomolgus CXCR1, Kd: 41 nM ¹²⁵I-CXCL8-CXCR1, IC₅₀: 43 nM	Mouse CXCR2, Kd: 0.2 nM Rat CXCR2, Kd: 0.2 nM Cynomolgus CXCR2, Kd: 0.08 nM ¹²⁵I-CXCL8-CXCR2, IC₅₀: 0.97 nM					98.90%
AZD8797			¹²⁵I-IL-8-CXCR2, Ki: 2800 nM (in HEK293S cells)					99.54%
AZD-5069			¹²⁵I-IL-8-CXCR2					99.91%
TAK-779				mCXCR3, IC₅₀: 369 nM (in PBMCs)				99.73%
Motixafortide					CXCR4, IC₅₀: ~1 nM			99.88%
SX-682		CXCR1	CXCR2					99.67%
ACT-1004-1239						CXCR7		99.80%
Mavorixafor trihydrochloride					¹²⁵I-SDF-CXCR4, IC₅₀: 13 nM			99.75%
Baohuoside I					CXCR4			99.96%
NUCC-390 dihydrochloride					CXCR4			99.05%
ML339							CXCR6, IC₅₀: 140 nM	99.88%
SCH 546738				Human CXCR3, Ki: 0.4 nM				98.71%
IT1t dihydrochloride					CXCL12/CXCR4, IC₅₀: 2.1 nM			99.77%
SB-265610			CXCR2					≥99.0%
VUF11207 fumarate						CXCR7, pKi: 8.1		98.50%
LY2510924					¹²⁵I-SDF-1α-CXCR4, IC₅₀: 79.7 pM ¹²⁵I-SDF-1α-CXCR4, Ki: 49.5 pM			99.73%
Danirixin			CXCL8-CXCR2, IC₅₀: 12.5 nM					98.88%
CXCR7 antagonist-1						CXCR7		99.97%
Reparixin L-lysine salt		CXCR1^wt, IC₅₀: 5.6 nM (in L1.2 cells) CXCR1^Ile43Val, IC₅₀: 80 nM (in L1.2 cells) CXCR1, IC₅₀: 1 nM (in cells)	CXCR2, IC₅₀: ∼100 nM (in cells)					99.66%
NBI-74330				[¹²⁵I]CXCL10-CXCR3, Ki: 1.5 nM (in CXCR3-CHO cell membranes) [¹²⁵I]CXCL11-CXCR3, Ki: 3.2 nM (in CXCR3-CHO cell membranes)				98.57%
Balixafortide TFA					CXCR4, IC₅₀: <10 nM			99.78%
WZ811					CXCR4, EC₅₀: 0.3 nM			99.80%
PS372424 hydrochloride				Human CXCR3				≥98.0%
Nicotinamide N-oxide			CXCR2					99.85%
Ulocuplumab					CXCR4			99.90%
ACT-777991				CXCR3				99.86%
TC14012					CXCR4, IC₅₀: 19.3 nM (antagonist site)	CXCR7, EC₅₀: 350 nM (agonist site)		99.90%
Elubrixin tosylate			CXCR2					99.78%
Ladarixin sodium		CXCR1	CXCR2					99.84%
AMD 3465 hexahydrobromide					12G5 mAb-CXCR4, IC₅₀: 0.75 nM (in SupT1 cells) CXCL12^AF647-CXCR4, IC₅₀: 18 nM (in SupT1 cells)			≥98.0%
CXCR2 antagonist 8			CXCR2					99.24%
Burixafor hydrobromide					CXCR4			≥98.0%
CXCR2-IN-1			CXCR2, pIC₅₀: 9.3					99.47%
MSX-122					CXCR4/CXCL12, IC₅₀: ~10 nM			98.92%
CXCR2-IN-2		CXCR1, IC₅₀: 3.8 μM	CXCR2, IC₅₀: 5.2 nM					99.52%
CTCE-9908					CXCR4			99.47%
CXCR7 antagonist-1 hydrochloride						CXCR7		99.66%
SX-517		CXCR1	CXCR2					99.88%
ALX 40-4C Trifluoroacetate					SDF-1-CXCR4, Ki: 1 μM
UNBS5162	CXCL							98.10%
CXCR7 modulator 2						CXCR7, Ki: 13 nM		98.71%
CTCE-0214					SDF-1α-CXCR4			98.94%
FC131 TFA					¹²⁵I-SDF-1-CXCR4, IC₅₀: 4.5 nM			99.89%
AMD 3465					12G5 mAb-CXCR4, IC₅₀: 0.75 nM (in SupT1 cells) CXCL12^AF647-CXCR4, IC₅₀: 18 nM (in SupT1 cells)			99.59%
SCH 563705		CXCR1, Ki: 3 nM CXCR1, IC₅₀: 7.3 nM	CXCR2, Ki: 1 nM CXCR2, IC₅₀: 1.3 nM Mouse CXCR2, IC₅₀: 5.2 nM					99.86%
ACT-660602				CXCR3, IC₅₀: 204 nM				99.86%
CXCR7 modulator 1						CXCR7, Ki: 9 nM		99.50%
SRT3190			CXCR2					99.77%
AMG 487 (S-enantiomer)				CXCR3				99.94%
USL311					CXCR4			99.97%
AZD8309			CXCR2, IC₅₀: 4 nM					99.98%
LIT-927					CXCL12/CXCR4, Ki: 267 nM			99.86%
MSX-127					CXCR4			99.68%
Elubrixin			CXCR2
IT1t					CXCL12/CXCR4, IC₅₀: 2.1 nM
ALX 40-4C					SDF-1-CXCR4, Ki: 1 μM
NUCC-390					CXCR4			98.40%
PS372424				Human CXCR3
Mavorixafor					¹²⁵I-SDF-CXCR4, IC₅₀: 13 nM
MSX-130					CXCR4			98.00%
KRH-3955 hydrochloride					SDF-1α-CXCR4, IC₅₀: 0.61 nM
FC131					¹²⁵I-SDF-CXCR4, IC₅₀: 4.5 nM
SRT3109			CXCR2, pIC₅₀: 8.2					99.82%
Mavorixafor hydrochloride					¹²⁵I-CXCL12-CXCR4, IC₅₀: 13 nM
Balixafortide					CXCR4, IC₅₀: <10 nM
AZ10397767			CXCR2, IC₅₀: 1 nM
CXCR4 antagonist 7					CXCR4/CXCL12, IC₅₀: 9.3 nM
CXCR4 antagonist 10					CXCR4, IC₅₀: 7.8 nM
Peptide R					CXCR4
CXCR2 antagonist 7			CXCR2, IC₅₀: 0.044 μM
Hit 14					12G5 mAb-CXCR4, IC₅₀: 254 nM
CTCE-9908 TFA					CXCR4
CXCR2 antagonist 6			CXCR2, IC₅₀: 0.43 μM
TC14012 TFA					CXCR4, IC₅₀: 19.3 nM (antagonist site)	CXCR7, EC₅₀: 350 nM (agonist site)
Nicotinamide N-oxide (Standard)			CXCR2
CXCR2 antagonist 5			CXCR2, IC₅₀: 0.013 μM
CXCR3 antagonist 1				CXCR3, IC₅₀: 0.06 μM
CXCR4 modulator-1					CXCR4, EC₅₀: 100 nM
CXCR4 antagonist 5					CXCR4, IC₅₀: 8.8 nM
CXCR4 antagonist 9					CXCR4, IC₅₀: 15 nM
CXCR4 antagonist 3					CXCR4, IC₅₀: 11 nM
CXCR4 antagonist 4					CXCR4, IC₅₀: 24 nM
TIQ-15					CXCR4, IC₅₀: 6 nM
ATI-2341					CXCR4, EC₅₀: 194 nM (in CCRF-CEM cells)
CCX662						CXCR7
CXCR4 modulator-2					CXCR4, IC₅₀: 1.25 nM
CXCR4 antagonist 8					CXCR4, IC₅₀: 57 nM
Corydalmine			CXCR2
Ac-Pro-Gly-Pro-OH			CXCR2
CXCR4 antagonist 1					CXCR4
BAM-12P						CXCR7, EC₅₀: 175 nM
HF50731					CXCR4, IC₅₀: 19.8 nM
EPI-X4					CXCR4, IC₅₀: 8.6 μM
CXCR4-IN-3					CXCR4, IC₅₀: 3.2 nM
ICT5040					CXCR4, IC₅₀: 3.8 μM
RCP168					CXCR4, IC₅₀: 5 nM
CXCR2 antagonist 4			CXCR2, IC₅₀: 0.13 μM
CXCR4 antagonist 6					CXCR4, IC₅₀: 79 nM
KRH-1636					CXCR4
VUF11207						CXCR7, pKi: 8.1

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