MAO-B-IN-19

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MAO-B-IN-19 is a selective MAO-B inhibitor with an IC₅₀ of 0.67 μM. MAO-B-IN-19 shows neuroprotective and anti-inflammatory properties.

For research use only. We do not sell to patients.

MAO-B-IN-19 Chemical Structure

CAS No. : 152897-41-1

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Description

MAO-B-IN-19 is a selective MAO-B inhibitor with an IC₅₀ of 0.67 μM. MAO-B-IN-19 shows neuroprotective and anti-inflammatory properties^[1].

IC₅₀ & Target^[1]

MAO-B

0.67 μM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	20.5 μM Compound: 3m	Cytotoxicity against human HCT116 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against human HCT116 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 23771043]
HeLa	IC₅₀	22.6 μM Compound: 1e, 1PF	Cytotoxicity against human HeLa cells assessed as decrease in cell survival after 72 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as decrease in cell survival after 72 hrs by MTT assay	[PMID: 23501110]
K562	IC₅₀	17.9 μM Compound: 1e, 1PF	Cytotoxicity against human K562 cells assessed as decrease in cell survival after 72 hrs by MTT assay Cytotoxicity against human K562 cells assessed as decrease in cell survival after 72 hrs by MTT assay	[PMID: 23501110]
MCF7	IC₅₀	26 μM Compound: 1e, 1PF	Cytotoxicity against human MCF7 cells assessed as decrease in cell survival after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as decrease in cell survival after 72 hrs by MTT assay	[PMID: 23501110]
PC-3	IC₅₀	30.4 μM Compound: 1e, 1PF	Cytotoxicity against human PC3 cells assessed as decrease in cell survival after 72 hrs by MTT assay Cytotoxicity against human PC3 cells assessed as decrease in cell survival after 72 hrs by MTT assay	[PMID: 23501110]
RAW264.7	IC₅₀	> 10 μM Compound: 12	Inhibition of LPS-stimulated ROS production in mouse RAW264.7 cells preincubated for 1 hr followed by LPS stimulation for 24 hrs measured after 30 mins by CMH2DCFDA probe-based fluorescence assay Inhibition of LPS-stimulated ROS production in mouse RAW264.7 cells preincubated for 1 hr followed by LPS stimulation for 24 hrs measured after 30 mins by CMH2DCFDA probe-based fluorescence assay	[PMID: 28159411]

In Vitro

MAO-B-IN-19 (compound 3f) significantly inhibits self-induced Aβ_1-42 aggregation and shows remarkable neuroprotective effects on Aβ25-35-induced PC12 cell injury. MAO-B-IN-19 is a selective metal chelator and could inhibit Cu²⁺-induced Aβ_1-42 aggregation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

242.25

Formula

C₁₅H₁₁FO₂

CAS No.

152897-41-1

SMILES

C1=CC=C(C(=C1)C(=O)/C=C/C2=CC=C(C=C2)F)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Rui Chen, et al. Development of the "hidden" multi-target-directed ligands by AChE/BuChE for the treatment of Alzheimer's disease. Eur J Med Chem. 2023 May 5;251:115253. [Content Brief]

MAO-B-IN-19 Related Classifications

Neurological Disease Inflammation/Immunology

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAO-B-IN-19152897-41-1Monoamine OxidaseMAOMAO-Banti-inflammatory propertyneuroprotectiveInhibitorinhibitorinhibit

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