2. Academic Validation
  3. Ammocidin, a new apoptosis inducer in Ras-dependent cells from Saccharothrix sp. I. Production, isolation and biological activity

Ammocidin, a new apoptosis inducer in Ras-dependent cells from Saccharothrix sp. I. Production, isolation and biological activity

  • J Antibiot (Tokyo). 2001 Sep;54(9):710-3. doi: 10.7164/antibiotics.54.710.
R Murakami 1,  T Tomikawa,  K Shin-ya,  J Shinozaki,  T Kajiura,  T Kinoshita,  A Miyajima,  H Seto,  Y Hayakawa
Affiliations

Affiliation

  • 1 Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan.
PMID: 11714226 DOI: 10.7164/antibiotics.54.710
Abstract

A new Apoptosis Inducer, ammocidin, was isolated from the culture broth of Saccharothrix sp. AJ9571. Ammocidin induced apoptotic cell death in Ras-dependent Ba/F3-V12 cells with an IC50 of 66 ng/ml. No cell death was observed in IL-3-dependent Ba/F3-V12 cells at less than 100 microg/ml of ammocidin. Ammocidin significantly reduced the phosphorylation level of MAPK and S6K that mediate the anti-apoptotic function of Ras.

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