2. Academic Validation
  3. Physanolide A, a novel skeleton steroid, and other cytotoxic principles from Physalis angulata

Physanolide A, a novel skeleton steroid, and other cytotoxic principles from Physalis angulata

  • Org Lett. 2006 Jul 6;8(14):2953-6. doi: 10.1021/ol060801s.
Ping-Chung Kuo 1,  Tsung-Hsiao Kuo,  Amooru G Damu,  Chung-Ren Su,  E-Jian Lee,  Tian-Shung Wu,  Rexen Shu,  Chou-Ming Chen,  Kenneth F Bastow,  Tzu-Hsuan Chen,  Kuo-Hsiung Lee
Affiliations

Affiliation

  • 1 Department of Chemistry, National Cheng Kung University, Tainan, Taiwan, Republic of China.
PMID: 16805525 DOI: 10.1021/ol060801s
Abstract

[reaction: see text] A novel withasteroid, physanolide A (1), with an unprecedented skeleton containing a seven-membered ring, and two new physalins, physalins U (2) and V (3), were isolated from Physalis angulata. The structures were elucidated from spectroscopic analysis, and plausible biosynthetic pathways were postulated. Physalins B (4), D (5), and F (6) showed strong cytotoxicity against multiple tumor cell lines, including KB, A431, HCT-8, PC-3, and ZR751, with EC(50) values less than 4 microg/mL.

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