2. Academic Validation
  3. Two sesquiterpene pyridine alkaloids and a triterpenoid saponin from the root barks of Tripterygium hypoglaucum

Two sesquiterpene pyridine alkaloids and a triterpenoid saponin from the root barks of Tripterygium hypoglaucum

  • J Asian Nat Prod Res. 2012;14(10):973-80. doi: 10.1080/10286020.2012.729049.
Chuang-Jun Li 1,  Fu-Gui Xie,  Jing-Zhi Yang,  Yong-Ming Luo,  Xiao-Guang Chen,  Dong-Ming Zhang
Affiliations

Affiliation

  • 1 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
PMID: 23046469 DOI: 10.1080/10286020.2012.729049
Abstract

Two new sesquiterpene Pyridine Alkaloids hypoglaunines E (1) and F (2) and a new triterpenoid saponin hypoglaside A (3), together with a known diterpenoid glucoside11-O-β-D-glucopyranosyl neotriptophenolide (4) and two known triterpenoids 23-noroxopristimerol(5) and 2,3-dihydroxy-6-oxo-D:A-froedo-24 nor-1,3,5(10),7-oleanatetraen-29-oic acid (6), have been isolated from the root barks of Tripterygiumhypoglaucum. Their structures were elucidated by NMR spectroscopy and MS analysis.Compounds 1–3 were screened for their cytotoxic activities against five Cancer celllines, but all of them were inactive.

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