2. Academic Validation
  3. Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice

Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice

  • Mol Nutr Food Res. 2017 Oct;61(10):10.1002/mnfr.201700139. doi: 10.1002/mnfr.201700139.
Sujin Suk 1,  Gyoo Taik Kwon 2,  Eunjung Lee 1,  Woo Jung Jang 1,  Hee Yang 1,  Jong Hun Kim 3,  N R Thimmegowda 4,  Min-Yu Chung 1,  Jung Yeon Kwon 5,  Seunghee Yang 1,  Jason K Kim 1 5,  Jung Han Yoon Park 2 3,  Ki Won Lee 1 3
Affiliations

Affiliations

  • 1 Major in Biomodulation, Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea.
  • 2 Department of Food Science and Nutrition, Hallym University, Chuncheon, Republic of Korea.
  • 3 Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, Republic of Korea.
  • 4 Chemical Biology Research Center and World Class Institute, Korea Research Institute of Bioscience and Biotechnology, Ochang, Republic of Korea.
  • 5 Program in Molecular Medicine and Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, University of Massachusetts Medical School, Worcester, MA, USA.
PMID: 28556482 DOI: 10.1002/mnfr.201700139
Abstract

Scope: Ginger exerts protective effects on obesity and its complications. Our objectives here are to identify bioactive compounds that inhibit adipogenesis and lipid accumulation in vitro, elucidate the anti-obesity effect of gingerenone A (GA) in diet-induced obesity (DIO), and investigate whether GA affects adipose tissue inflammation (ATI).

Methods and results: Oil red O staining showed that GA had the most potent inhibitory effect on adipogenesis and lipid accumulation in 3T3-L1 cells among ginger components tested at a single concentration (40 μM). Consistent with in vitro data, GA attenuates DIO by reducing fat mass in mice. This was accompanied by a modulation of fatty acid metabolism via activation of AMP-activated protein kinase (AMPK) in vitro and in vivo. Additionally, GA suppressed ATI by inhibiting macrophage recruitment and downregulating pro-inflammatory cytokines.

Conclusion: These results suggest that GA may be used as a potential therapeutic candidate for the treatment of obesity and its complications by suppressing adipose expansion and inflammation.

Keywords

AMP-activated protein kinase; Adipocyte; Adipose tissue inflammation; Gingerenone A; Obesity.

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