2. Academic Validation
  3. Aucubin: potential antidote for alpha-amanitin poisoning

Aucubin: potential antidote for alpha-amanitin poisoning

  • J Toxicol Clin Toxicol. 1984 Jul;22(1):77-85. doi: 10.3109/00099308409035083.
L M Chang,  H S Yun,  Y S Kim,  J W Ahn
PMID: 6208374 DOI: 10.3109/00099308409035083
Abstract

Aucubin, an iridoid glucoside isolated from Aucuba japonica (Cornaceae), exhibited significant protective activity against alpha-amanitin intoxication in mice. When a single dose of aucubin was administered intraperitoneally, a 50% survival rate was obtained even when the treatment was withheld for 12 hr after alpha-amanitin administration. A possible mechanism of protective activity is partly due to a competitive effect of aucubin on alpha-amanitin inhibition of liver RNA biosynthesis.

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