2. Epigenetics PROTAC
  3. Histone Methyltransferase PROTACs
  4. MS33

MS33 is a potent WDR5 degrader, with Kds of 870 nM and 120 nM for VCB and WDR5, respectively. MS33 induces WDR5 degradation in an E3 ligase VHL, and proteasome-dependent manner. MS33 can be used for the research of acute myeloid leukemia.

For research use only. We do not sell to patients.

MS33 Chemical Structure

MS33 Chemical Structure

CAS No. : 2407449-11-8

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Based on 1 publication(s) in Google Scholar

MS33 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

MS33 is a potent WDR5 degrader, with Kds of 870 nM and 120 nM for VCB and WDR5, respectively. MS33 induces WDR5 degradation in an E3 ligase VHL, and proteasome-dependent manner. MS33 can be used for the research of acute myeloid leukemia[1][2][3].

IC50 & Target[1]

VHL

 

WDR5

120 nM (Kd)

VCB

870 nM (Kd)

In Vitro

MS33 (0.05-5 μM; 18 h) induces WDR5 degradation in a concentration-dependent manner in MV4;11 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MS33 Related Antibodies

Western Blot Analysis[1]

Cell Line: MV4;11 cells
Concentration: 0.05, 0.1, 0.5, 1, 5 μM
Incubation Time: 1, 2, 4, 8, 16, 24 hours
Result: Concentration- and time-dependently induced WDR5 degradation.
The DC50 of MS33 was 260 nM, and the maximum degradation of 71%.
Molecular Weight

1208.48

Formula

C64H84F3N11O7S
CAS No.
SMILES

CN(CC1)CCN1C(C(NC(C2=CNC(C=C2C(F)(F)F)=O)=O)=C3)=CC=C3C4=CC(CN5CCN(CCNC(CCCCCCCCCC(N[C@@H](C(C)(C)C)C(N6C[C@H](O)C[C@H]6C(NCC7=CC=C(C8=C(C)N=CS8)C=C7)=O)=O)=O)=O)CC5)=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MS33 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MS332407449-11-8MS 33MS-33Histone MethyltransferasePROTACsWDR5VCBE3ligaseVHLproteasomeacutemyeloidleukemiaInhibitorinhibitorinhibit

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