Platyconic acid A

Name: Platyconic acid A
Brand: MedChemExpress
SKU: HY-N9377
Rating: 4.5 (1 reviews)

Cat. No.: HY-N9377 Purity: 99.08%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Platyconic Acid A is an active component of changkil saponins from platycodon grandiflorum and can be used for the research of reducing airway inflammation.

For research use only. We do not sell to patients.

Platyconic acid A Chemical Structure

CAS No. : 68051-23-0

Size	Price	Stock	Quantity
1 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 400	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 640	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Platyconic Acid A is an active component of changkil saponins from platycodon grandiflorum and can be used for the research of reducing airway inflammation^[1].

In Vitro

Platyconic Acid A (0.5~2 μM; 30 minutes; A549 cells) inhibits PMA-induced NF-κB p65 phosphorylation, IκBα phosphorylation and degradation and Akt phosphorylation in a concentration-dependent manner^[1].
Platyconic Acid A (0.5~2 μM; 24 hours; A549 cells) decreases PMA-increased MUC5AC mRNA expression in a concentration-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	A549 cells
Concentration:	0.5~2 μM
Incubation Time:	30 minutes
Result:	Inhibited PMA-induced NF-κB p65 phosphorylation, IκBα phosphorylation and degradation and Akt phosphorylation in a concentration-dependent manner.

RT-PCR^[1]

Cell Line:	A549 cells
Concentration:	0.5~2 μM
Incubation Time:	24 hours
Result:	Decreased PMA-increased MUC5AC mRNA expression in a concentration-dependent manner.

Molecular Weight

1239.31

Formula

C₅₇H₉₀O₂₉

CAS No.

68051-23-0

Appearance

Solid

Color

White to off-white

SMILES

C[C@H]1[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3[C@H](O)[C@](CO)(O)CO3)[C@H](O)CO2)[C@@H](O)[C@@H](O)[C@H](O[C@@H]4[C@@H](O)[C@@H](O)CO[C@H]4OC([C@]56CCC(C)(C)C[C@H]5C7=CC[C@H]8[C@](CC[C@@H]9[C@]8(C)C[C@H](O)[C@H](O[C@H]%10[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O%10)[C@@]9(C(O)=O)CO)(C)[C@]7(C)C[C@H]6O)=O)O1

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

H₂O : 25 mg/mL (20.17 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.8069 mL	4.0345 mL	8.0690 mL
5 mM	0.1614 mL	0.8069 mL	1.6138 mL
10 mM	0.0807 mL	0.4035 mL	0.8069 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.08%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (251 KB) RP-HPLC (127 KB)

Handling Instructions (2659 KB)

References

[1]. Choi JH, et al. Saponins, especially platyconic acid A, from Platycodon grandiflorum reduce airway inflammation in ovalbumin-induced mice and PMA-exposed A549 cells. J Agric Food Chem. 2015;63(5):1468-1476. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	0.8069 mL	4.0345 mL	8.0690 mL	20.1725 mL
	5 mM	0.1614 mL	0.8069 mL	1.6138 mL	4.0345 mL
	10 mM	0.0807 mL	0.4035 mL	0.8069 mL	2.0173 mL
	15 mM	0.0538 mL	0.2690 mL	0.5379 mL	1.3448 mL
	20 mM	0.0403 mL	0.2017 mL	0.4035 mL	1.0086 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.