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Results for "

ATX

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Biochemical Assay Reagents (1) Cholinesterase (ChE) (1) Interleukin Related (1) Liposome (4) LPL Receptor (2) nAChR (1) p97 (1) Phosphodiesterase (PDE) (30) Sodium Channel (3) TGF-beta/Smad (1)
By Research Areas:	Cancer (24) Cardiovascular Disease (2) Inflammation/Immunology (15) Metabolic Disease (1) Neurological Disease (6)
Oligonucleotides:	Cationic Lipids (4)

Inhibitors & Agonists

Biochemical Assay Reagents

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Isotope-Labeled Compounds

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-149167

ATX-0126 ATX 100	Liposome Biochemical Assay Reagents	Others
ATX-0126 (Compound 2) is a Thiocarbamate-Based Ionizable Lipid. ATX-0126 can be used as an excipient in mRNA-encapsulating lipid nanoparticle .

HY-142654

ATX-002	Liposome	Others
ATX-002 is an ionizable cationic lipid for RNA drug delivery. The calculated pKa (c-pKa) and measured pKa values for ATX-002 are 8.68 and 6.03, respectively .

HY-145739

ATX-0114	Liposome	Others
ATX-0114 is an ionizable cationic lipid .

HY-143583

ATX inhibitor 10	Others	Neurological Disease Cancer
ATX inhibitor 10 is a potent inhibitor of *ATX. ATX* inhibitor 10 is s nitrogen-containing heterocyclic compound. ATX plays a role in causing pathological conditions including fibrosis, arthritis, neurodegeneration, neuropathic pain, and cancer. ATX inhibitor 10 has the potential for the research of ATX related diseases (extracted from patent WO2021115375A1, compound 35) .

HY-143420

ATX inhibitor 15	Phosphodiesterase (PDE)	Inflammation/Immunology
ATX inhibitor 15 (compound 30), a indole-based carbamate derivative, is a potent autotaxin (ATX) inhibitor with an IC₅₀ of 2.17 nM. ATX inhibitor 15 inhibits in vivo ATX and the gene expression of pro-fibrotic factors. ATX inhibitor 15 has lung protection effects in Bleomycin challenged mice lung fibrosis model .

HY-143582

ATX inhibitor 9	Others	Cancer
ATX inhibitor 9 is a potent inhibitor of ATX. ATX inhibitor 9 is a thickened heteroaryl derivatives compound. Autotaxin (ATX), also known as ENPP2, is a secreted enzyme that is highly expressed mainly in cancer cells, bronchial epithelial cells and alveolar macrophages in the lung. ATX inhibitor 9 has the potential for the research of cancer or fibrous degenerative disease (extracted from patent WO2021078227A1, compound 3) .

HY-143419

ATX inhibitor 14	Phosphodiesterase (PDE)	Inflammation/Immunology
ATX inhibitor 14 (compound 4), a indole-based carbamate derivative, is a potent autotaxin (ATX) inhibitor with an IC₅₀ of 0.41 nM. ATX inhibitor 14 has the potential for fibrosis relevant diseases research .

HY-149018

ATX inhibitor 22	Phosphodiesterase (PDE)	Cancer
ATX inhibitor 22 is a novel inhibitor of *ATX* (autotaxin) with IC₅₀ of 218 nM but lost its inhibitory activity of LPAR1 .

HY-W590548

ATX-001	Liposome	Others
ATX-001 is an ionizable cationic lipid. ATX-001 can be used in the formation of lipid nanoparticles (LNPs) for the delivery mRNA .

HY-P1604

ATX-II	Sodium Channel	Inflammation/Immunology
ATX-II is a specific Na ⁺ channel Modulator toxin that can be isolated from the venom of sea anemone (Anemonia sulcata). ATX-II causes delayed inactivation of the Na ⁺ATX-II sensitizes skeletal muscle to Halothane (HY-B1010), Caffeine, and Ryanodine (HY-103306). ATX-II also induces pulmonary vein arrhythmogenesis and atrial fibrillation .

HY-146205

ATX inhibitor 18	Phosphodiesterase (PDE)	Cardiovascular Disease
ATX inhibitor 18 is a potent *ATX* inhibitor with an IC₅₀ value of 24.2 nM. ATX inhibitor 18 shows antiproliferative activity and anti-fibrosis activity. ATX inhibitor 18 suppresses collagen deposition in TGF-β-mediated cardiac fibrosis .

HY-P1604A

ATX-II TFA	Sodium Channel	Inflammation/Immunology
ATX-II TFA is a specific Na ⁺ channel Modulator toxin that can be isolated from the venom of sea anemone (Anemonia sulcata). ATX-II TFA causes delayed inactivation of the Na ⁺ATX-II TFA sensitizes skeletal muscle to Halothane (HY-B1010), Caffeine, and Ryanodine (HY-103306). ATX-II TFA also induces pulmonary vein arrhythmogenesis and atrial fibrillation .

HY-146889

ATX inhibitor 16	Others	Cancer
ATX inhibitor 16 is a potent *ATX* inhibitor with an IC₅₀ of 0.0021 µM. ATX inhibitor 16 shows excellent anti-proliferative activities in breast cancer cells .

HY-146890

ATX inhibitor 17	Others	Cancer
ATX inhibitor 17 is a potent *ATX* inhibitor with an IC₅₀ of 0.019 µM. ATX inhibitor 17 shows excellent anti-proliferative activities in breast cancer cells .

HY-146122

ATX inhibitor 19	Phosphodiesterase (PDE)	Cancer
ATX inhibitor 19 (compound 22) is a potent *ATX* (autotaxin) inhibitor, with an IC₅₀ of 156 nM .

HY-146124

ATX inhibitor 21	Phosphodiesterase (PDE)	Cancer
ATX inhibitor 21 (compound 8) is a potent *ATX* (autotaxin) inhibitor, with an IC₅₀ of 3490 nM .

HY-144766

ATX inhibitor 13	Apoptosis	Cancer
ATX inhibitor 13 (10c) is an orally active and potent *ATX* inhibitor, with an IC₅₀ of 3.4 nM. ATX inhibitor 13 inhibits proliferation and migration, and induces apoptosis and G2 phase arrest in RAW264.7 cells. ATX inhibitor 13 suppresses tumor cell colony formation .

HY-146123

ATX inhibitor 20	Phosphodiesterase (PDE)	Cancer
ATX inhibitor 20 (compound 24) is a potent *ATX* (autotaxin) inhibitor, with an IC₅₀ of 2.3 nM .

HY-143237

ATX inhibitor 11	Phosphodiesterase (PDE)	Others
ATX inhibitor 11 (compound 13c) is a potent *ATX* (autotaxin) inhibitor, with an IC₅₀ of 2.7 nM. ATX inhibitor 11 can typically alleviate the severity of fibrosis tissues and effectively reduce the deposition of fibrotic biomarker α-SMA in mice fibrosis model. ATX inhibitor 11 can be used for lung fibrosis research .

HY-143581

ATX inhibitor 8	Phosphodiesterase (PDE)	Inflammation/Immunology
ATX inhibitor 8 is a Autotaxin (ATX) inhibitor extracted from patent WO2018212534A1 compound 96 .

HY-133019

ATX inhibitor 5	Phosphodiesterase (PDE)	Inflammation/Immunology
ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor, with an IC₅₀ of 15.3 nM. ATX inhibitor 5 shows anti-hepatofibrosis effects and reduces CCl4-induced hepatic fibrosis level prominently .

HY-163093

ATX inhibitor 24	Others	Cancer
ATX inhibitor 24 is a potent ATX inhibitor with IC₅₀ of 7.51±0.72 nM that has anti-tumor effect .

HY-111410

ATX inhibitor 1	Phosphodiesterase (PDE)	Cancer
ATX inhibitor 1 is a potent *ATX* (IC₅₀=1.23 nM, FS-3 and 2.18 nM, bis-pNPP) inhibitor.

HY-144743

ATX inhibitor 12	Phosphodiesterase (PDE)	Others
ATX inhibitor 12 (compound 20) is an orally active and potent *ATX* (autotaxin) inhibitor, with an IC₅₀ of 1.72 nM. ATX inhibitor 12 effectively alleviates lung structural damage with fewer fibrotic lesions at an oral dose of 60 mg/kg in C57Bl/6J mice. ATX inhibitor 12 can be uesd for idiopathic pulmonary fibrosis (IPF) research .

HY-142644

ATX inhibitor 7	Phosphodiesterase (PDE)	Inflammation/Immunology
ATX inhibitor 7 is a autotaxin inhibitor and shows good oral exposure.

HY-W795027

Anatoxin-a ATX-a	nAChR Cholinesterase (ChE)	Neurological Disease
Anatoxin-a (ATX-a) is a neurotoxic alkaloid. Anatoxin-a acts as both a nicotinic acetylcholine receptor (nAChR) agonist and an Acetylcholinesterase (AChE) inhibitor .

HY-124772

BI-2545	Phosphodiesterase (PDE)	Inflammation/Immunology
BI-2545 is a potent autotaxin (ATX) inhibitor that significantly reduces LPA, with IC₅₀s of 2.2 nM and 3.4 nM for human ATX and rat ATX, respectively .

HY-139096

4-Pentadecylbenzylphosphonic acid	Phosphodiesterase (PDE)	Cancer
4-Pentadecylbenzylphosphonic acid is an Autotaxin (ATX) inhibitor. 4-Pentadecylbenzylphosphonic acid has antitumor activity .

HY-116100A

HA155	Phosphodiesterase (PDE)	Inflammation/Immunology
HA-155 is a potent and selective autotaxin (ATX) inhibitor with an IC₅₀ of 5.7 nM .

HY-149716

MEY-003	Phosphodiesterase (PDE)	Cancer
MEY-003 is an *Autotaxin(ATX)* inhibitor with EC₅₀s of 460 nM and 1.09 μM for hATX-β and hATX-ɣ (analysis with LPC18:1). MEY-003 behaves as a non-competitive inhibitor with K_iof 432 nM. MEY-003 can be used for targeted ATX-related disease research .

HY-126233

PAT-347	Phosphodiesterase (PDE)	Metabolic Disease
PAT-347 is an Autotaxin (ATX) inhibitor. ATX is a secretory enzyme that hydrolyzes lysophosphatidylcholine (LPC) and regulates lysophosphatidic acid (LPA) production in the blood .

HY-145344

ONO-8430506	Phosphodiesterase (PDE)	Cancer
ONO-8430506 is an orally bioavailable and potent autotaxin (ATX)/ENPP2 inhibitor with the IC₉₀ of 100 nM for ATX activity in mouse plasma .

HY-120797

CRT0273750	LPL Receptor	Cancer
CRT0273750 is an autotaxin (ATX) inhibitor and modulates LPA levels in plasm (IC₅₀ = 0.014 μM). CRT0273750 can be used in ATX/LPA-dependent models of cancer .

HY-126230

PAT-494	Others	Others
PAT-494 is an ATX inhibitor with significant activity in biochemical and plasma assays. PAT-494 can reduce LPA levels in rat plasma through oral administration. The structure-activity relationship study of PAT-494 shows that its binding mode with ATX is novel and it can effectively occupy the hydrophobic pockets and channels of ATX .

HY-19329

HA130 4 Publications Verification	Phosphodiesterase (PDE)	Cancer
HA130 is a selective autotaxin (ATX) inhibitor with an IC₅₀ of 28 nM.

HY-169004

CBT-295	TGF-beta/Smad Interleukin Related	Neurological Disease Inflammation/Immunology
CBT-295 is an orally active autotaxin (ATX) inhibitor. CBT-295 exhibits a significant reduction in inflammatory cytokines like TGF-β, TNF-α and IL-6 levels, also reduced bile duct proliferation marker CK-19 and lowered liver fibrosis. The reversal of liver fibrosis with CBT-295 led to a reduction in blood and brain ammonia levels. CBT-295 also reduced neuroinflammation induced by ammonia. CBT-295 is promising for research of liver cirrhosis and associated encephalopathy .

HY-145561

Cudetaxestat BLD-0409	Phosphodiesterase (PDE)	Inflammation/Immunology
Cudetaxestat (BLD-0409) is a potent and orally active autotaxin (ATX) inhibitor .

HY-157997

MHC02181	Phosphodiesterase (PDE)	Cancer
MHC02181 is a potent inhibitor of Autotaxin (ATX), with IC₅₀ of 9.41 μM .

HY-158001

MHC00188	Phosphodiesterase (PDE)	Others Cancer
MHC00188 is an allosteric inhibitor for Autotaxin (ATX) with an IC₅₀ of 2.53 μM .

HY-101772

Ziritaxestat 5 Publications Verification GLPG1690	Phosphodiesterase (PDE)	Inflammation/Immunology
Ziritaxestat (GLPG1690) is a first-in-class autotaxin (ATX) inhibitor, with an IC₅₀ of 131 nM and a K_i of 15 nM .

HY-135053

Autotaxin-IN-3	Phosphodiesterase (PDE)	Inflammation/Immunology
Autotaxin-IN-3 is a *Autotaxin(ATX)* inhibitor with an IC₅₀ of 2.4 nM, compound 33, sourced from patent WO2018212534A1 .

HY-103035

BIO-32546	Phosphodiesterase (PDE)	Cancer
BIO-32546 (example 12b, S-isomer) is an autotaxin (ATX) modulator (IC₅₀: 1 nM), extracted from the patent US20170158687A1 .

HY-169300

KR-40795	Phosphodiesterase (PDE)	Inflammation/Immunology
KR-40795 is a potent inhibitor of ATX (autotaxin), with the IC₅₀ of 0.13 μM. KR-40795 plays an important role for liver diseases .

HY-110078

Eeyarestatin I 3 Publications Verification	p97 Apoptosis	Cancer
Eeyarestatin I, a potent endoplasmic reticulum-associated protein degradation (ERAD) inhibitor, is a potent protein translocation inhibitor. Eeyarestatin I inhibits Sec61 translocon. Eeyarestatin I targets the p97-associated deubiquitinating process (PAD) and inhibits atx3-dependent deubiquitination. Eeyarestatin I interferes at a step prior to proteasomal degradation. Eeyarestatin I induces cell death via the proapoptotic protein NOXA and has anticancer effects .

HY-116100

(E/Z)-HA155	Phosphodiesterase (PDE)	Neurological Disease Inflammation/Immunology Cancer
(E/Z)-HA155 is a potent *autotaxin (ATX) type I* inhibitor. (E/Z)-HA155 can be used for researching cancer, fibrotic diseases, inflammation, pain and angiogenesis .

HY-134954

Palmitoleoyl 3-carbacyclic phosphatidic acid	Others	Cancer
Palmitoleoyl 3-carbacyclic phosphatidic acid (3ccPA 16:1) is an intermediately potent inhibitor of autotaxin (ATX) with an IC₅₀ of 620 nM. Palmitoleoyl 3-carbacyclic phosphatidic acid can be used for melanoma research .

HY-150614

Autotaxin-IN-6	Phosphodiesterase (PDE) LPL Receptor	Cancer
Autotaxin-IN-6 (compound 23) is a potent autotaxin (ATX) inhibitor with an IC₅₀ value of 30 nM. Autotaxin-IN-6 can reduce cell migration. Autotaxin-IN-6 can be used for researching anticancer .

HY-157639A

18:2 Lyso PA sodium	Others	Cardiovascular Disease
18:2 Lyso PA sodium is an unsaturated lysophosphatidic acid (LysoPA), a lipid mediator mainly present in plasma and thought to be involved in the pathogenesis of acute coronary syndrome (ACS). 18:2 Lyso PA sodium significantly correlates with serum autotaxin (ATX) in peripheral arteries .

HY-12812

Autotaxin modulator 1	Phosphodiesterase (PDE)	Neurological Disease Cancer
Autotaxin modulator 1 is an autotaxin (ATX) enzyme inhibitor, extracted from patent WO 2014018881 A1, Compound Example 12b. Autotaxin modulator 1 is expected to be useful for researching demyelination due to injury or disease, as well as for researching proliferative disorders such as cancer .

HY-148792

Relutrigine PRAX-562	Sodium Channel	Neurological Disease
Relutrigine (PRAX-562) is an orally active inhibitor of persistent sodium channel. Relutrigine potently and preferentially inhibits persistent I_Na induced by ATX-II (Nav 1.5 activator) or the SCN8A mutation N1768D with IC₅₀ values of 141 nM and 75 nM, respectively. Relutrigine exhibits potent use-dependent block and reduces neuronal intrinsic excitability. Relutrigine has effective anticonvulsant activity .

Cat. No.	Product Name	Type

HY-149167

ATX-0126 ATX 100	Drug Delivery
ATX-0126 (Compound 2) is a Thiocarbamate-Based Ionizable Lipid. ATX-0126 can be used as an excipient in mRNA-encapsulating lipid nanoparticle .

HY-142654

ATX-002	Drug Delivery
ATX-002 is an ionizable cationic lipid for RNA drug delivery. The calculated pKa (c-pKa) and measured pKa values for ATX-002 are 8.68 and 6.03, respectively .

HY-145739

ATX-0114	Drug Delivery
ATX-0114 is an ionizable cationic lipid .

Cat. No.	Product Name	Target	Research Area

HY-P1604A

ATX-II TFA	Sodium Channel	Inflammation/Immunology
ATX-II TFA is a specific Na ⁺ channel Modulator toxin that can be isolated from the venom of sea anemone (Anemonia sulcata). ATX-II TFA causes delayed inactivation of the Na ⁺ATX-II TFA sensitizes skeletal muscle to Halothane (HY-B1010), Caffeine, and Ryanodine (HY-103306). ATX-II TFA also induces pulmonary vein arrhythmogenesis and atrial fibrillation .

HY-P1604

ATX-II	Sodium Channel	Inflammation/Immunology
ATX-II is a specific Na ⁺ channel Modulator toxin that can be isolated from the venom of sea anemone (Anemonia sulcata). ATX-II causes delayed inactivation of the Na ⁺ATX-II sensitizes skeletal muscle to Halothane (HY-B1010), Caffeine, and Ryanodine (HY-103306). ATX-II also induces pulmonary vein arrhythmogenesis and atrial fibrillation .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W795027

Anatoxin-a ATX-a	Structural Classification Alkaloids Microorganisms Pyrrole Alkaloids Source classification	nAChR Cholinesterase (ChE)
Anatoxin-a (ATX-a) is a neurotoxic alkaloid. Anatoxin-a acts as both a nicotinic acetylcholine receptor (nAChR) agonist and an Acetylcholinesterase (AChE) inhibitor .

Species:	Human (3)
Tag:	His (3)
Source:	HEK293 (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P70167

	ENPP-2 Protein, Human (HEK293, His) rHuEctonucleotide phosphodiesterase family member 2/ENPP-2, His ; ATX; ATXFLJ26803; ATX-X; Autotaxin; autotaxin-t; EC 3.1.4.39; ectonucleotide pyrophosphatase/phosphodiesterase 2; E-NPP 2; ENPP2; LysoPLD; NPP2; PD-IALPHA; PDNP2; PDNP2NPP2	Human	HEK293
	The ENPP-2 protein catalyzes the hydrolysis of lysophospholipids (especially lysophosphatidylcholine) to produce the signaling molecule lysophosphatidic acid (LPA). It also acts on sphingosine phosphocholine to produce sphingosine 1-phosphate, which affects cell movement. ENPP-2 Protein, Human (HEK293, His) is the recombinant human-derived ENPP-2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of ENPP-2 Protein, Human (HEK293, His) is 828 a.a., with molecular weight of 100-120 kDa.

HY-P75585

	ATOX1 Protein, Human (His) Copper transport protein ATOX1; Metal transport protein ATX1; HAH1	Human	E. coli
	ATOX1 Protein plays a crucial role in cellular copper transport, binding to and delivering cytosolic copper to copper ATPase proteins. This process is integral to cellular antioxidant defense mechanisms. ATOX1 functions as a homodimer, supported by research findings. It interacts with ATP7B and ATP7A. In its dimer form, ATOX1 interacts with SLC31A1, contributing to its stability and controlling intracellular Cu(I) levels. ATOX1 Protein, Human (His) is the recombinant human-derived ATOX1 protein, expressed by E. coli , with N-His labeled tag. The total length of ATOX1 Protein, Human (His) is 68 a.a., with molecular weight of ~9 kDa.

HY-P79456

	Ataxin-3 Protein, Human (His) Ataxin-3; ATXN3; Machado-Joseph disease protein 1; Spinocerebellar ataxia type 3 protein; ATX3, MJD, MJD1; SCA3	Human	E. coli
	Ataxin-3 is a deubiquitinating enzyme that maintains proteostasis, regulates transcription, and is involved in cytoskeletal dynamics, myogenesis, and degradation of misfolded chaperone substrates. It trims long polyubiquitin chains and interacts with STUB1/CHIP to limit ubiquitin chain length, preventing further elongation. Ataxin-3 Protein, Human (His) is the recombinant human-derived Ataxin-3 protein, expressed by E. coli , with N-6*His labeled tag. The total length of Ataxin-3 Protein, Human (His) is 361 a.a., with molecular weight of ~43 kDa.

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Cat. No.	Product Name	Chemical Structure

HY-169071S

ATX-1905

ATX-1905 is a positron emission tomography (PET) tracer that demonstrates good autotaxin (ATX) binding specificity and achieves semiquantification of lung ATX expression levels, which are elevated in fibrotic lungs. ATX-1905 exhibits elevated uptake in Bleomycin (HY-108345)-induced pulmonary fibrosis (BPF) lungs. ATX-1905 is promising for research of idiopathic pulmonary fibrosis (IPF) .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82242

	SMG1 Antibody (YA1987) 61E3.4; ATX; hSMG1; LIP; smg1	WB	Human, Mouse, Rat
	SMG1 Antibody (YA1987) is a biotin-conjugated non-conjugated IgG antibody, targeting SMG1, with a predicted molecular weight of 411 kDa (observed band size: 411 kDa). SMG1 Antibody (YA1987) can be used for WB experiment in human, mouse, rat background.

HY-P81549

	Ataxin 3 Antibody (YA1294) ATX3, MJD, MJD1, SCA3, ATXN3	IHC-P	Human, Mouse, Rat
	Ataxin 3 Antibody (YA1294) is a biotin-conjugated non-conjugated IgG antibody, targeting Ataxin 3. Ataxin 3 Antibody (YA1294) can be used for IHC-P experiment in human, mouse, rat background.

HY-P82432

	Ataxin 1 Antibody (YA2177) ATX1; SCA1; D6S504E	WB, IP	Mouse
	Ataxin 1 Antibody (YA2177) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2177), targeting Ataxin 1, with a predicted molecular weight of 87 kDa (observed band size: 105 kDa). Ataxin 1 Antibody (YA2177) can be used for WB, IP experiment in mouse background.

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Cat. No.	Product Name		Classification

HY-149167

ATX-0126 ATX 100		Cationic Lipids
ATX-0126 (Compound 2) is a Thiocarbamate-Based Ionizable Lipid. ATX-0126 can be used as an excipient in mRNA-encapsulating lipid nanoparticle .

HY-142654

ATX-002		Cationic Lipids
ATX-002 is an ionizable cationic lipid for RNA drug delivery. The calculated pKa (c-pKa) and measured pKa values for ATX-002 are 8.68 and 6.03, respectively .

HY-145739

ATX-0114		Cationic Lipids
ATX-0114 is an ionizable cationic lipid .

HY-W590548

ATX-001		Cationic Lipids
ATX-001 is an ionizable cationic lipid. ATX-001 can be used in the formation of lipid nanoparticles (LNPs) for the delivery mRNA .

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ATX

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Natural
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