ATX inhibitor 18 

ATX inhibitor 18 is a potent ATX inhibitor with an IC₅₀ value of 24.2 nM. ATX inhibitor 18 shows antiproliferative activity and anti-fibrosis activity. ATX inhibitor 18 suppresses collagen deposition in TGF-β-mediated cardiac fibrosis^[1].

ATX inhibitor 18 (compound 8b) (10 µM; 48 h) shows antiproliferative activity in CFs, t-HSC/Cl-6 cells^[1].
ATX inhibitor 18 (0-4 µM) shows anti-fibrosis activity with IC₅₀s of 0.87 and 1.10 µM for CFs, t-HSC/Cl-6 cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

459.30

C₂₁H₁₇Cl₂FN₆O

2402772-30-7

O=C(N1CCC2=C(C(NC3=CC=C(C(Cl)=C3)F)=NC=N2)C1)N/N=C/C4=CC=C(C=C4)Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Jiang N, et al. Optimization and evaluation of novel tetrahydropyrido[4,3-d]pyrimidine derivatives as ATX inhibitors for cardiac and hepatic fibrosis. Eur J Med Chem. 2020 Feb 1;187:111904.  [Content Brief]

  [2]. Jiang N, et al. Optimization and evaluation of novel tetrahydropyrido[4,3-d]pyrimidine derivatives as ATX inhibitors for cardiac and hepatic fibrosis. Eur J Med Chem. 2020 Feb 1;187:111904.