ATX-0126 (Synonyms: ATX 100)

Cat. No.: HY-149167 Purity: 99.94%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

ATX-0126 (Compound 2) is a Thiocarbamate-Based Ionizable Lipid. ATX-0126 can be used as an excipient in mRNA-encapsulating lipid nanoparticle.

For research use only. We do not sell to patients.

ATX-0126 Chemical Structure

CAS No. : 2230647-37-5

Size	Price	Stock	Quantity
1 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 190	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 320	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 695	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1180	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2000	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Description

ATX-0126 (Compound 2) is a Thiocarbamate-Based Ionizable Lipid. ATX-0126 can be used as an excipient in mRNA-encapsulating lipid nanoparticle^[1].

Molecular Weight

755.23

Formula

C₄₄H₈₆N₂O₅S

CAS No.

2230647-37-5

Appearance

Liquid (Density: 0.958±0.06 g/cm³)

Color

Colorless to light yellow

SMILES

O=C(N(CCCC(OC(CCCCCCC)CCCCCCC)=O)CCCC(OC(CCCCCCC)CCCCCCC)=O)SCCCN(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

Ethanol : 20 mg/mL (26.48 mM; Need ultrasonic)

DMSO : 2 mg/mL (2.65 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3241 mL	6.6205 mL	13.2410 mL
5 mM	0.2648 mL	1.3241 mL	2.6482 mL
10 mM	0.1324 mL	0.6620 mL	1.3241 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.94%

Select Batch:

Data Sheet (266 KB) SDS (393 KB)

COA (242 KB) HNMR (139 KB) RP-HPLC (245 KB)

Handling Instructions (2659 KB)

References

[1]. Kumar Rajappan, et al. Development of a Safe and Scalable Process for the Production of a High-Purity Thiocarbamate-Based Ionizable Lipid as an Excipient in mRNA-Encapsulating Lipid Nanoparticles. Org. Process Res. Dev. 2021, 25, 6, 1383-1390.

[2]. Preparation of ionizable cationic lipids for RNA delivery. US20180170866A1

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / Ethanol	1 mM	1.3241 mL	6.6205 mL	13.2410 mL	33.1025 mL
Ethanol	5 mM	0.2648 mL	1.3241 mL	2.6482 mL	6.6205 mL
	10 mM	0.1324 mL	0.6620 mL	1.3241 mL	3.3102 mL
	15 mM	0.0883 mL	0.4414 mL	0.8827 mL	2.2068 mL
	20 mM	0.0662 mL	0.3310 mL	0.6620 mL	1.6551 mL
	25 mM	0.0530 mL	0.2648 mL	0.5296 mL	1.3241 mL

ATX-0126 Related Classifications

Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ATX-01262230647-37-5ATX 100ATX0126ATX 0126ATX100ATX-100LiposomeBiochemical Assay ReagentsLipidexcipientthiocarbamatemRNAInhibitorinhibitorinhibit

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