2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. ATX inhibitor 12

ATX inhibitor 12 (compound 20) is an orally active and potent ATX (autotaxin) inhibitor, with an IC50 of 1.72 nM. ATX inhibitor 12 effectively alleviates lung structural damage with fewer fibrotic lesions at an oral dose of 60 mg/kg in C57Bl/6J mice. ATX inhibitor 12 can be uesd for idiopathic pulmonary fibrosis (IPF) research.

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ATX inhibitor 12 Chemical Structure

ATX inhibitor 12 Chemical Structure

CAS No. : 2771312-16-2

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ATX inhibitor 12 Related Antibodies

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PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

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Description

ATX inhibitor 12 (compound 20) is an orally active and potent ATX (autotaxin) inhibitor, with an IC50 of 1.72 nM. ATX inhibitor 12 effectively alleviates lung structural damage with fewer fibrotic lesions at an oral dose of 60 mg/kg in C57Bl/6J mice. ATX inhibitor 12 can be uesd for idiopathic pulmonary fibrosis (IPF) research[1].

IC50 & Target

Autotaxin

1.72 nM (IC50)

Molecular Weight

515.62

Formula

C30H34FN5O2
CAS No.
SMILES

CCC1=C(N2C=C(C=C(C2=N1)C)C3=CC=C(C=C3)CN4CCC(CC4)O)NC(NCC5=CC=C(C=C5)F)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ATX inhibitor 12 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ATX inhibitor 122771312-16-2ATX inhibitor12ATX inhibitor-12Phosphodiesterase (PDE)Imidazo[1,2-a]pyridineHybrid strategyUreaAnti-fibrosisAutotaxin (ATX)benzylamine derivativephosphodiesterasidiopathic pulmonary fibrosis (IPF)orally activeInhibitorinhibitorinhibit

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