2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. p97

p97

VCP; Cdc48

p97

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p97 (also referred to as VCP) is a highly conserved and abundant AAA+ (ATPases associated with diverse cellular activities) ATPase that plays an essential role in cellular proteostasis. p97 participates in a large number of important cellular activities, including (i) proteasomal degradation, through its roles in extracting proteins from membranes or molecular complexes; (ii) lysosomal degradation via autophagy and endolysosomal sorting; (iii) membrane fusion; and (iv) regulation of intracellular signaling, cell proliferation, and survival. These diverse cellular functions are powered by the chemical energy from ATP hydrolysis and coordinated through the interaction of p97 with as many as 40 cofactors that recruit it to specific subcellular locations and to designated substrates for their remodeling and processing.

Mutations in p97 have been linked to a number of neurodegenerative diseases, and overexpression of wild type p97 is observed in numerous cancers. Furthermore, p97 activity has been shown to be essential for the replication of certain viruses, including poliovirus, herpes simplex virus (HSV), cytomegalovirus (CMV), and influenza. These observations highlight the potential for targeting p97 as a therapeutic approach in neurodegeneration, cancer, and certain infectious diseases.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-12861
    CB-5083
    		Inhibitor 99.90%
    CB-5083 is a first-in-class, potent, selective, and orally bioavailable inhibitor of the p97 AAA ATPase/VCP. CB-5083 selectively inhibits p97 through its D2 site with the IC50 of 11 nM.
    CB-5083
  • HY-15713
    NMS-873
    		Inhibitor 99.87%
    NMS-873 is a potent, selective allosteric VCP/p97 inhibitor with an IC50 value of 30 nM.
    NMS-873
  • HY-110078
    Eeyarestatin I
    		Inhibitor 98.96%
    Eeyarestatin I, a potent endoplasmic reticulum-associated protein degradation (ERAD) inhibitor, is a potent protein translocation inhibitor. Eeyarestatin I inhibits Sec61 translocon. Eeyarestatin I targets the p97-associated deubiquitinating process (PAD) and inhibits atx3-dependent deubiquitination. Eeyarestatin I interferes at a step prior to proteasomal degradation. Eeyarestatin I induces cell death via the proapoptotic protein NOXA and has anticancer effects.
    Eeyarestatin I
  • HY-15945
    DBeQ
    		Inhibitor 99.02%
    DBeQ is a selective, potent, reversible, and ATP-competitive p97 inhibitor, with an IC50 value of 1.5 μM and 1.6 μM for p97(wt) and p97(C522A), respectively; DBeQ also inhibits Vps4 with an IC50 of 11.5 μM.
    DBeQ
  • HY-123872
    MSC1094308
    		Inhibitor 99.89%
    MSC1094308 is a non-competitive and reversible VPS4B/p97 (VCP) (I/II type AAA ATPase) allosteric inhibitor, with IC50 values of 0.71 μM and 7.2 μM for VPS4B and p97, respectively. MSC1094308 inhibits the D2 ATPase activity by binding to a agentable hotspot of p97. MSC1094308 can be used in study of cancer.
    MSC1094308
  • HY-138233
    KUS121
    		Modulator ≥98.0%
    KUS121, a valosin-containing protein (VCP, p97) modulator with significant neuroprotective effects, attenuates ischemic retinal cell death via suppressing endoplasmic reticulum stress.
    KUS121
  • HY-168006
    NSC819701
    		Inhibitor
    NSC819701 is a triazole inhibitor of the p97 ATPase. NSC819701 inhibits the activity of p97 ATPase by binding to a specific site of p97.
    NSC819701
  • HY-168005
    NSC799462
    		Inhibitor
    NSC799462 is a triazole inhibitor of p97 ATPase. NSC799462 inhibits p97 ATPase activity (IC50 = 15 nM) by binding to a specific site on p97 and causing local changes in the p97 structure.
    NSC799462
  • HY-19795
    ML240
    		Inhibitor 99.87%
    ML240 is a potent p97 inhibitor, inhibiting p97 ATPase with IC50 value of 100 nM.
    ML240
  • HY-128724
    CB-5339
    		Inhibitor 99.58%
    CB-5339 is an oral activity potent p97 inhibitor with an IC50 <30 nM. CB-5339 can be used for leukemia research. CB-5339 extracted from WO2015109285A1 compound FF07.
    CB-5339
  • HY-19797A
    ML241 hydrochloride
    		Inhibitor 99.79%
    ML241 hydrochloride is a potent p97 inhibitor, inhibiting p97 ATPase with IC50 value of 100 nM.
    ML241 hydrochloride
  • HY-157508
    VCP Activator 1
    		Activator 99.71%
    VCP Activator 1 is a VCP activator that dose-dependently stimulates VCP ATPase activity. VCP Activator 1 binds an allosteric pocket near the C-terminus. In addition, VCP Activator 1 binding site can also be occupied by a phenylalanine residue in the VCP C-terminal tail.
    VCP Activator 1
  • HY-123636
    UPCDC-30245
    		Inhibitor 99.85%
    UPCDC-30245 is an allosteric p97 inhibitor with an IC50 of approximately 27 nM. UPCDC-30245 inhibits the p97 mutant N660K similar to wild type (WT; IC50=300 nM) and shows 3-fold resistance for p97 mutant T688A. UPCDC-30245 can be used in the research of cancer.
    UPCDC-30245
  • HY-15714
    NMS-859
    		Inhibitor 98.05%
    NMS-859 is a potent, covalent VCP (p97) inhibitor, with IC50s of 0.37 and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.
    NMS-859
  • HY-19797
    ML241
    		Inhibitor 99.96%
    ML241 is a potent, selective and competitive p97 ATPase inhibitor with an IC50 of 0.11 μM. ML241 can be used for the research of cancer.
    ML241
  • HY-155026
    UPCDC30766
    		Inhibitor 99.31%
    UPCDC30766 is a potent allosteric inhibitor of p97, with an IC50 of 12 nM. UPCDC30766 can be used for the research of colon cancer. UPCDC30766 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    UPCDC30766
  • HY-148122
    NW 1028
    		Inhibitor
    NW 1028 is a potent VCP/p97 inhibitor. NW 1028 targets the ND1L domain of p97 and inhibits the degradation of a p97-dependent reporter. NW 1028 has good binding affinity with Kd values of 100 and 285 nM for ND1L and full length p97, respectively. NW 1028 has the function of regulating the mitotic spindle of cells.
    NW 1028
  • HY-139606
    VCP/p97 inhibitor-1
    		Inhibitor
    VCP/p97 inhibitor-1 is a potent inhibitor of VCP/p97 (also called Cdc48, CDC-. 48, or Ter94) with an IC50 of 54.7 nM. VCP/p97 inhibitor-1 causes the dysregulation of protein homeostasis and disturbs the degradation of misfolded polypeptides by the ubiquitin-proteasome system (UPS).
    VCP/p97 inhibitor-1
Cat. No. Product Name / Synonyms Application Reactivity