MEY-003

Cat. No.: HY-149716: FAQs
Data Sheet Handling Instructions

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MEY-003 is an Autotaxin(ATX) inhibitor with EC₅₀s of 460 nM and 1.09 μM for hATX-β and hATX-ɣ (analysis with LPC18:1). MEY-003 behaves as a non-competitive inhibitor with K_iof 432 nM. MEY-003 can be used for targeted ATX-related disease research .

For research use only. We do not sell to patients.

MEY-003 Chemical Structure

CAS No. : 3047891-88-0

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•Related Small Molecules:

•Related Proteins:

View All Phosphodiesterase (PDE) Isoform Specific Products:

View All Isoforms

PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Autotaxin

In Vitro

MEY-003 (10 μM, 30 min) blocks lysophosphatidic acid (LPA) signaling, and reduces LPA1 receptor internalization in HeLa cell^[1].
MEY-003 (100 μM, 0-24 h) shows no cytotoxicity effects in HeLa and HEK293 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	HeLa and HEK293 cells
Concentration:	100 μM
Incubation Time:	0-24 h
Result:	Showed non-cytotoxic after prolonged treatment (up to 24 h) at 100 μM with HeLa cells or HEK293 cells.

Molecular Weight

363.41

Formula

C₂₂H₂₁NO₄

CAS No.

3047891-88-0

SMILES

OC1=C2C(OC(C3=CN(CCCCC)C4=C3C=CC=C4)=CC2=O)=CC(O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Eymery M C, et al. Discovery of potent chromone-based autotaxin inhibitors inspired by cannabinoids [J]. European Journal of Medicinal Chemistry, 2023: 115944. [Content Brief]

MEY-003 Related Classifications

Molarity Calculator
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MEY-0033047891-88-0MEY003MEY 003Phosphodiesterase (PDE)HeLaHEK293 cellsInhibitorATXinhibitorinhibit

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