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Results for "

BMPS

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AAK1 (6) ADC Linker (1) Akt (1) AMPK (2) Apoptosis (5) Autophagy (4) Biochemical Assay Reagents (1) c-Myc (2) Caspase (2) Checkpoint Kinase (Chk) (1) COX (1) Cyclin G-associated Kinase (GAK) (2) EGFR (1) ERK (1) Estrogen Receptor/ERR (1) FGFR (2) Glucosidase (1) GSK-3 (1) JAK (2) JNK (1) Kisspeptin Receptor (2) LIM Kinase (LIMK) (1) MAP3K (1) MEK (1) NF-κB (3) Organoid (5) p38 MAPK (1) PDGFR (1) PI3K (1) Potassium Channel (1) Procollagen C Proteinase (1) Prostaglandin Receptor (1) RAR/RXR (2) Reactive Oxygen Species (2) Ribosomal S6 Kinase (RSK) (1) Small Interfering RNA (siRNA) (12) Sodium Channel (1) Src (2) TGF-beta/Smad (4) TGF-β Receptor (22) Thyroid Hormone Receptor (2) TRP Channel (1) VEGFR (2) Wee1 (1) Wnt (1) β-catenin (2)
By Research Areas:	Cancer (29) Cardiovascular Disease (8) Inflammation/Immunology (6) Metabolic Disease (10) Neurological Disease (8)
Oligonucleotides:	Pre-designed siRNA Sets (12) siRNAs (12)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-42146

*BMPS*	ADC Linker	Cancer
BMPS is a nonclaevable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-124697

BMP signaling agonist sb4 4 Publications Verification	TGF-β Receptor	Cancer
BMP signaling agonist sb4 is a potent benzoxazole *bone morphogenetic protein 4 (BMP4) signaling* agonist with a EC₅₀ value of 74 nM, activates BMP signaling by stabilizing intracellular p-SMAD-1/5/9. BMP signaling agonist sb4 activates BMP4 target genes (inhibitors of DNA binding, Id1 and Id3) canonical BMP signaling .

HY-143891

Chromenone 1	TGF-β Receptor	Others
Chromenone 1 is a potent osteogenic bone morphogenetic protein *(BMP)* potentiator. Chromenone 1 exhibits a unique mode of action as it induces a pronounced, kinase-independent, negative TGFβ feedback that enhances nuclear BMP-Smad signaling outputs .

HY-147372

SJ000063181	TGF-beta/Smad	Metabolic Disease
SJ000063181 is a potent BMP signaling activator with an EC₅₀ ≤1 µM. SJ000063181 can be used as chemical probes to interrogate BMP signaling due to it can penetrate zebrafish embryos .

HY-N4019

Maohuoside A	TGF-β Receptor	Metabolic Disease
Maohuoside A, a single compound isolated from the E. koreanum that potently promotes osteogenesis. Maohuoside A enhances the osteogenesis of bone marrow-derived mesenchymal stem cells via bone morphogenetic protein (BMP) and MAPK signaling pathways .

HY-123900

AZ12799734	TGF-β Receptor	Cardiovascular Disease
AZ12799734 is a selective, orally active TGFBR1 kinase inhibitor with an IC₅₀ of 47 nM. AZ12799734 is also a pan *BMP* and TGFβ inhibitor .

HY-12071

LDN193189 50+ Cited Publications DM-3189	Organoid TGF-β Receptor	Cancer
LDN193189 is a potent selective BMP type I receptor (BMP I) inhibitor. LDN-193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC₅₀ values of 5 nM and 30 nM, respectively. LDN-193189 can be used for the research of bone morphogenetic protein signalling, such as fibrodysplasia ossificans progressiva .

HY-108531

ER 50891	RAR/RXR	Cancer
ER-50891 is a potent antagonist of retinoic acid receptor α(RARα). ER-50891 significantly attenuates ATRA's inhibitive effects on BMP 2-induced osteoblastogenesis .

HY-155705

BMP agonist 1	TGF-β Receptor GSK-3 β-catenin	Others
BMP agonist 1 (compound 2 b) is a small-molecule agonist of bone morphogenic protein (BMP). BMP induces C2C12 cell differentiation with BMP and highly depends on active BMP signaling. BMP agonist 1 inhibits GSK3β, increases β-catenin signaling and synergistically regulates Id2and Id3 expression. BMP agonist 1 is used in diseases and defects of the skeleton research .

HY-164145

CDD-1653	TGF-β Receptor	Others Cancer
CDD-1653 is a potent and selective BMPR2 inhibitor (IC₅₀=2.8 nM). CDD-1653 reduces the ability of ATP to bind to the kinase domain of BMPR2, thereby affecting the phosphorylation of SMAD1/5/8 transcription factors, which play a key role in the BMP signaling pathway. CDD-1653 can be used to study diseases related to the BMP signaling pathway .

HY-108531A

ER 50891 quarterhydrate	RAR/RXR	Cancer
ER 50891 quarterhydrate is a potent antagonist of retinoic acid receptor α(RARα). ER 50891 quarterhydrate significantly attenuates ATRA's inhibitive effects on BMP 2-induced osteoblastogenesis .

HY-13418A

Dorsomorphin Maximum Cited Publications 504 Publications Verification Compound C; BML-275	Organoid AMPK TGF-β Receptor Autophagy	Cancer
Dorsomorphin (Compound C) is a selective and ATP-competitive AMPK inhibitor (K_i=109 nM in the absence of AMP). Dorsomorphin (BML-275) selectively inhibits BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599) .

HY-13418

Dorsomorphin dihydrochloride Maximum Cited Publications 504 Publications Verification Compound C dihydrochloride; BML-275 dihydrochloride	Organoid AMPK TGF-β Receptor Autophagy	Cancer
Dorsomorphin (Compound C) dihydrochloride is a potent, selective and ATP-competitive AMPK inhibitor, with a K_i of 109 nM. Dorsomorphin dihydrochloride inhibits BMP pathway by targeting the type I receptors ALK2, ALK3, and ALK6. Dorsomorphin dihydrochloride can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599).

HY-150793

SY-LB-57	TGF-β Receptor	Cardiovascular Disease Neurological Disease
SY-LB-57 is a highly potent bone morphogenetic protein (BMP) receptor signaling agonist. SY-LB-57 can be used in studies of diseases such as fractures and pulmonary arterial hypertension .

HY-P99359

Elezanumab ABT-555; AE12-1Y-QL; Anti-RGMA Reference Antibody (elezanumab)	TGF-beta/Smad	Metabolic Disease
Elezanumab (ABT-555; AE12-1Y-QL) is a human monoclonal antibody that selectively targets repulsive guidance molecule A (RGMa). Elezanumab potently inhibited RGMa mediated BMP signalling via the SMAD1/5/8 pathway, with an IC₅₀ around 97 pM. Elezanumab promotes neuroregeneration and neuroprotection in neuronal injury and demyelination models binds N-terminal RGMa, blocks BMP signaling and lacks RGMc cross-reactivity. elezanumab has neuroregenerative and neuroprotective activities without impact on iron metabolism .

HY-150795

SY-LB-35	TGF-beta/Smad PI3K Akt ERK JNK	Others
SY-LB-35 is a potent *bone morphogenetic protein (BMP) receptor* agonist. SY-LB-35 can stimulate significant increases in cell number and cell viability in the C2C12 myoblast cell line, and causes shifts towards the S and G2/M phases of the cell cycle. SY-LB-35 stimulates canonical Smad and non-canonical PI3K/Akt, ERK, p38 and JNK intracellular signaling pathways .

HY-N0123

Aloin 5+ Cited Publications Aloin-A; Barbaloin-A	Others	Cancer
Aloin (Aloin-A; Barbaloin-A) is a natural anti-tumor anthraquinone glycoside with iron chelating activity. Aloin induces the differentiation of MC3T3-E1 cells into osteoblasts through MAPK-mediated Wnt and Bmp signaling pathways. Alkaline phosphatase (ALP) is an early marker of osteoblast differentiation, and the activity of ALP is also enhanced by Aloin. Aloin also reduces brain edema, reduces blood-brain barrier disruption and improves cortical impact injuries. Aloin is used in research into osteoporosis and traumatic brain injury (TBI) .

HY-158203

BMP agonist 2	Others	Others
BMP agonist 2 (derivative I-9) is a potent bone-inducing cytokine. BMP agonist 2 promotes bone tissue production by increasing the proportion and activity of osteoblasts. BMP agonist 2 promotes osteoblast proliferation and differentiation through the *BMP2-ATF4* signaling axis, in which ATF4 is a transcription factor closely related to osteoblast differentiation and bone formation. BMP agonist 2 can be used in the study of senile osteoporosis (SOP) .

HY-N0123R

Aloin (Standard)	Others	Cancer
Aloin (Standard) is the analytical standard of Aloin. This product is intended for research and analytical applications. Aloin (Aloin-A; Barbaloin-A) is a natural anti-tumor anthraquinone glycoside with iron chelating activity. Aloin induces the differentiation of MC3T3-E1 cells into osteoblasts through MAPK-mediated Wnt and Bmp signaling pathways. Alkaline phosphatase (ALP) is an early marker of osteoblast differentiation, and the activity of ALP is also enhanced by Aloin. Aloin also reduces brain edema, reduces blood-brain barrier disruption and improves cortical impact injuries. Aloin is used in research into osteoporosis and traumatic brain injury (TBI) .

HY-15897

LDN-212854 1 Publications Verification	TGF-β Receptor	Cancer
LDN-212854 is a bone morphogenetic protein (BMP) inhibitor that potently inhibits ALK2 (IC₅₀: 1.3 nM). LDN-212854 also inhibits ALK1 (IC₅₀: 2.40 nM). LDN-212854 can be used in the research of fibrodysplasia ossificans progressive and cancers, such as hepatocellular carcinoma (HCC) .

HY-12071G

LDN193189 DM-3189	TGF-β Receptor	Cancer
LDN193189 (DM-3189) (GMP) is LDN193189 (HY-12071) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. LDN193189 is selective BMP type I receptor inhibitor .

HY-N8920

Syringetin	Others	Metabolic Disease
Syringetin, a flavonoid derivative, is associated with increased BMP-2 production. Syringetin stimulates osteoblast differentiation at various stages, from maturation to terminally differentiated osteoblasts .

HY-112331

SJ000291942 3 Publications Verification	TGF-β Receptor	Cancer
SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway. BMPs are members of the transforming growth factor beta (TGFβ) family of secreted signaling molecules.

HY-RS01533

BMP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
BMP1 Human Pre-designed siRNA Set A contains three designed siRNAs for BMP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BMP1 Human Pre-designed siRNA Set A BMP1 Human Pre-designed siRNA Set A

HY-RS01534

BMP10 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
BMP10 Human Pre-designed siRNA Set A contains three designed siRNAs for BMP10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BMP10 Human Pre-designed siRNA Set A BMP10 Human Pre-designed siRNA Set A

HY-RS01535

BMP15 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
BMP15 Human Pre-designed siRNA Set A contains three designed siRNAs for BMP15 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BMP15 Human Pre-designed siRNA Set A BMP15 Human Pre-designed siRNA Set A

HY-RS01536

BMP2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
BMP2 Human Pre-designed siRNA Set A contains three designed siRNAs for BMP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BMP2 Human Pre-designed siRNA Set A BMP2 Human Pre-designed siRNA Set A

HY-RS01538

BMP3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
BMP3 Human Pre-designed siRNA Set A contains three designed siRNAs for BMP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BMP3 Human Pre-designed siRNA Set A BMP3 Human Pre-designed siRNA Set A

HY-RS01539

BMP4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
BMP4 Human Pre-designed siRNA Set A contains three designed siRNAs for BMP4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BMP4 Human Pre-designed siRNA Set A BMP4 Human Pre-designed siRNA Set A

HY-RS01540

BMP5 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
BMP5 Human Pre-designed siRNA Set A contains three designed siRNAs for BMP5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BMP5 Human Pre-designed siRNA Set A BMP5 Human Pre-designed siRNA Set A

HY-RS01541

BMP6 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
BMP6 Human Pre-designed siRNA Set A contains three designed siRNAs for BMP6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BMP6 Human Pre-designed siRNA Set A BMP6 Human Pre-designed siRNA Set A

HY-RS01542

BMP7 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
BMP7 Human Pre-designed siRNA Set A contains three designed siRNAs for BMP7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BMP7 Human Pre-designed siRNA Set A BMP7 Human Pre-designed siRNA Set A

HY-RS01543

BMP8A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
BMP8A Human Pre-designed siRNA Set A contains three designed siRNAs for BMP8A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BMP8A Human Pre-designed siRNA Set A BMP8A Human Pre-designed siRNA Set A

HY-RS01537

BMP2K Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
BMP2K Human Pre-designed siRNA Set A contains three designed siRNAs for BMP2K gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BMP2K Human Pre-designed siRNA Set A BMP2K Human Pre-designed siRNA Set A

HY-RS01544

BMP8B Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
BMP8B Human Pre-designed siRNA Set A contains three designed siRNAs for BMP8B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BMP8B Human Pre-designed siRNA Set A BMP8B Human Pre-designed siRNA Set A

HY-N2682B

Dehydrodiconiferyl alcohol	Estrogen Receptor/ERR	Metabolic Disease Inflammation/Immunology
Dehydrodiconiferyl alcohol is an estrogen receptor agonist that can promote BMP-2-induced osteoblastogenesis. Dehydrodiconiferyl alcohol also exerts anti-inflammatory activity through inactivation of NF-κB pathways .

HY-12071B

LDN-193189 dihydrochloride 50+ Cited Publications DM-3189 dihydrochloride	TGF-β Receptor Organoid	Cancer
LDN-193189 (dihydrochloride) is a potent selective BMP type I receptor (BMP I) inhibitor. LDN-193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC₅₀ values of 5 nM and 30 nM, respectively. LDN-193189 can be used for the research of bone morphogenetic protein signalling, such as fibrodysplasia ossificans progressiva .

HY-18961

PD 407824	Checkpoint Kinase (Chk) Wee1	Inflammation/Immunology Cancer
PD 407824 is a checkpoint kinase Chk1 and WEE1 inhibitor with IC₅₀s of 47 and 97 nM, respectively. PD 407824 is a chemical BMP sensitizer and increases the sensitivity of cells to sub-threshold amounts of BMP4 .

HY-121025

BUR1	TGF-β Receptor	Others
BUR1 is a *BMP* upregulator (EC₅₀: 98 nM) and activates BMPRII signalling. BUR1 induces BMP2 and PTGS2 expression. BUR1 reversed pulmonary arterial pressure in Monocrotaline (HY-N0750) induced rats .

HY-167580

*18:1 Hemi BMP* (S,R)**	Biochemical Assay Reagents
18:1 Hemi BMP (S,R) is a kind of biochemical reagent.

HY-P5157

BmP02	Potassium Channel	Neurological Disease
BmP02 is a selective Kv1.3 channel blocker and a highly-selective Kv4.2 modulator, which can be isolated from Chinese scorpion (Buthus martensi Karsch) venom. BmP02 also delays the inactivation of Kv4.2 in HEK293T cells, with an EC₅₀ value of ~850 nM. BmP02 inhibits the transient outward potassium currents (Ito) in ventricular muscle cells .

HY-13102

UK-383367	Procollagen C Proteinase	Others
UK-383367 is an orally available pro-collagen C-protease inhibitor (BMP-1) with an IC₅₀ value of 44 nM. UK-383367 can reduce renal fibrosis and inflammation in chronic kidney disease (CKD) and may be used to study postoperative skin scarring .

HY-135871

BMT-124110	AAK1	Neurological Disease
BMT-124110 is a potent, selective AAK1 inhibitor with an IC₅₀ of 0.9 nM. BMT-124110 shows antinociceptive activity. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC₅₀s of 17 and 99 nM, respectively .

HY-N2375

L-Quebrachitol	Wnt β-catenin p38 MAPK	Metabolic Disease
L-Quebrachitol is a methoxy analog of inositol isolated from plants, which has free-radical scavenging, gastroprotection, anti-platelet aggregation and anti-diabetic activity. L-Quebrachitol promotes osteoblastogenesis by uppregulation of *BMP-2, runt-related transcription factor-2 (Runx2), MAPK* (ERK, JNK, p38α), and Wnt/β-catenin signaling pathway .

HY-N0265

Asperosaponin VI 2 Publications Verification	Caspase Apoptosis	Cardiovascular Disease
Asperosaponin VI, A saponin component from Dipsacus asper, induces osteoblast differentiation through BMP‐2/p38 and ERK1/2 pathway . Asperosaponin Ⅵ inhibits apoptosis in hypoxia-induced cardiomyocyte by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing of p-Akt and p-CREB .

HY-101290

BMT-090605	AAK1 Cyclin G-associated Kinase (GAK)	Neurological Disease
BMT-090605 is a potent, selective the adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC₅₀ value of 0.6 nM. BMT-090605 shows antinociceptive activity. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC₅₀ values of 45 nM and 60 nM, respectively. BMT-090605 can be used for the research of neuropathic pain .

HY-101290A

BMT-090605 hydrochloride	Cyclin G-associated Kinase (GAK) AAK1	Neurological Disease
BMT-090605 hydrochloride is a potent, selective the adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC₅₀ value of 0.6 nM. BMT-090605 hydrochloride shows antinociceptive activity. BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC₅₀ values of 45 nM and 60 nM, respectively. BMT-090605 hydrochloride can be used for the research of neuropathic pain .

HY-16712

LDN-214117 1 Publications Verification	TGF-β Receptor	Cancer
LDN-214117 is an orally active ALK2 inhibitor with well-tolerated and good brain penetration. LDN-214117 has a high selectivity and low cytotoxicity for ALK2 with an IC₅₀ value of 24 nM. LDN-214117 also is a specific bone morphogenetic proteins (BMPs) signaling inhibitor and has relatively selective inhibition for BMP6 with an IC₅₀ value of 100 nM. LDN-214117 can be used for the research of fibrodysplasia ossificans progressiva (FOP), diffuse intrinsic pontine glioma (DIPG) ^[2]

HY-120179

LP-922761 1 Publications Verification	AAK1	Neurological Disease
LP-922761 is a potent, selective and orally active adapter protein-2 associated kinase 1 (AAK1) inhibitor with IC₅₀s of 4.8 nM and 7.6 nM in enzyme and cell assays, respectively. LP-922761 also inhibits BMP-2-inducible protein kinase (BIKE) with an IC₅₀ of 24 nM. LP-922761 exhibits no significant activity at cyclin G-associated kinase (GAK), opioid, adrenergic α2 or GABAa receptors .

HY-120179A

LP-922761 hydrate	AAK1	Neurological Disease
LP-922761 hydrate is a potent, selective and orally active adapter protein-2 associated kinase 1 (AAK1) inhibitor with IC₅₀s of 4.8 nM and 7.6 nM in enzyme and cell assays, respectively. LP-922761 hydrate also inhibits BMP-2-inducible protein kinase (BIKE) with an IC₅₀ of 24 nM. LP-922761 hydrate shows less activity at cyclin G-associated kinase (GAK), opioid, adrenergic α2 or GABAa receptors .

Cat. No.	Product Name

HY-L038

Differentiation Inducing Compound Library

1,491 compounds

Stem cells, which are found in all multi-cellular organisms, can divide and differentiate into diverse special cell types and can self-renew to produce more stem cells. To be useful in therapy, stem cells must be converted into desired cell types as necessary which is called induced differentiation or directed differentiation. Understanding and using signaling pathways for differentiation is an important method in successful regenerative medicine. Small molecules or growth factors induce the conversion of stem cells into appropriate progenitor cells, which will later give rise to the desired cell type. There is a variety of signal molecules and molecular families that may affect the establishment of germ layers in vivo, such as fibroblast growth factors (FGFs); the wnt family or superfamily of transforming growth factors β (TGFβ) and bone morphogenetic proteins (BMP). Unfortunately, for now, a high cost of recombinant factors is likely to limit their use on a larger scale in medicine. The more promising technique focuses on the use of small molecules. These small molecules can be used for either activating or deactivating specific signaling pathways. They enhance reprogramming efficiency by creating cells that are compatible with the desired type of tissue. It is a cheaper and non-immunogenic method.

MCE Differentiation Inducing Compound Library contains a unique collection of 1,491 compounds that act on signaling pathways for differentiation. These compounds are potential stimulators for induced differentiation. This library is a useful tool for researching directed differentiation and regenerative medicine.

HY-L018

TGF-beta/Smad Compound Library

247 compounds

The transforming growth factor beta (TGF-β) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. The TGF-β superfamily comprises TGF-βs, bone morphogenetic proteins (BMPs), activins and related proteins. Signaling begins with the binding of a TGF beta superfamily ligand to a TGF beta type II receptor. The type II receptor is a serine/threonine receptor kinase, which catalyzes the phosphorylation of the Type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD (e.g. SMAD4). R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression. Deregulation of TGF-β signaling contributes to developmental defects and human diseases, including cancers, some bone diseases, chronic kidney disease, etc.

MCE designs a unique collection of 247 TGF-beta/Smad signaling pathway compounds. TGF-beta/Smad Compound Library acts as a useful tool for TGF-beta/Smad-related drug screening and disease research.

Cat. No.	Product Name	Type

HY-12071G

LDN193189 (GMP) DM-3189 (GMP)	Biochemical Assay Reagents
LDN193189 (DM-3189) (GMP) is LDN193189 (HY-12071) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. LDN193189 is selective BMP type I receptor inhibitor .

HY-167580

*18:1 Hemi BMP* (S,R)**	Drug Delivery
18:1 Hemi BMP (S,R) is a kind of biochemical reagent.

Cat. No.	Product Name	Target	Research Area

HY-P5832

BMP2-derived peptide	Peptides	Others
BMP2-derived peptide is a functional motif from positions 73 to 92 of the amino acid sequence of BMP-2. BMP2-derived peptide promotes osteogenic differentiation of bone marrow stromal cells (BMSCs) and enhances bone regeneration .

HY-P0254

Kisspeptin-10, human	Kisspeptin Receptor	Cardiovascular Disease Cancer
Kisspeptin-10, human is a potent vasoconstrictor and inhibitor of angiogenesis. Kisspeptin-10, human acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role in embryonic kidney development. Kisspeptin-10/GPR54 signaling induces osteoblast differentiation via NFATc4-mediated BMP2 expression .

HY-P0254A

Kisspeptin-10, human TFA	Kisspeptin Receptor	Cardiovascular Disease Cancer
Kisspeptin-10, human TFA is a potent vasoconstrictor and inhibitor of angiogenesis. Kisspeptin-10, human TFA acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role in embryonic kidney development. Kisspeptin-10/GPR54 signaling induces osteoblast differentiation via NFATc4-mediated BMP2 expression .

HY-P1252

Parathyroid Hormone (1-34), bovine 1 Publications Verification	Thyroid Hormone Receptor	Metabolic Disease
Parathyroid Hormone (1-34), bovine is a potent parathyroid hormone (PTH) receptor agonist. Parathyroid Hormone (1-34), bovine increases calcium and inorganic phosphate levels in vivo. Parathyroid Hormone (1-34), bovine can be used for th reseach of osteoporosis .

HY-P5457

BMP-2 Epitope (73-92)	Peptides	Others
BMP-2 Epitope (73-92) is a biological active peptide. (This is amino acids 73 to 92 fragment of bone morphogenetic protein (BMP) knuckle epitope. It is a member of transforming growth factor beta (TGF-b). This peptide fragment is able to raise alkaline phosphate activity in murine multipotent mesenchymal cells.)