2. TGF-beta/Smad
  3. TGF-β Receptor
  4. BUR1

BUR1 is a BMP upregulator (EC50: 98 nM) and activates BMPRII signalling. BUR1 induces BMP2 and PTGS2 expression. BUR1 reversed pulmonary arterial pressure in Monocrotaline (HY-N0750) induced rats.

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BUR1 Chemical Structure

BUR1 Chemical Structure

CAS No. : 23000-46-6

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Based on 1 publication(s) in Google Scholar

BUR1 Related Antibodies

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Description

BUR1 is a BMP upregulator (EC50: 98 nM) and activates BMPRII signalling. BUR1 induces BMP2 and PTGS2 expression. BUR1 reversed pulmonary arterial pressure in Monocrotaline (HY-N0750) induced rats[1].

In Vitro

BUR1 (0.2 μM, 15 min-24 h) increases expression of Inhibitor of DNA binding 1 (Id1) and phosphorylation of Smad1/5 in PAECs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BUR1 Related Antibodies
In Vivo

BUR1 (4.5 mg/day, i.g., 3 weeks) reverses MCT-induced pulmonary arterial pressure and right ventricular systolic pressure in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

279.34

Formula

C16H17N5
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

C12=NC=NC(N3CCCCC3)=C1C=NN2C4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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BUR1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BUR123000-46-6BUR 1BUR-1TGF-β ReceptorTransforming growth factor beta receptorspulmonary arterial pressurePAHMCTInhibitorinhibitorinhibit

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