2. Stem Cell/Wnt TGF-beta/Smad
  3. TGF-beta/Smad
  4. Elezanumab

Elezanumab  (Synonyms: ABT-555; AE12-1Y-QL; Anti-RGMA Reference Antibody (elezanumab))

Cat. No.: HY-P99359 Purity: 99.69%
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Elezanumab (ABT-555; AE12-1Y-QL) is a human monoclonal antibody that selectively targets repulsive guidance molecule A (RGMa). Elezanumab potently inhibited RGMa mediated BMP signalling via the SMAD1/5/8 pathway, with an IC50 around 97 pM. Elezanumab promotes neuroregeneration and neuroprotection in neuronal injury and demyelination models binds N-terminal RGMa, blocks BMP signaling and lacks RGMc cross-reactivity. elezanumab has neuroregenerative and neuroprotective activities without impact on iron metabolism.

For research use only. We do not sell to patients.

CAS No. : 1791416-49-3

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Based on 1 publication(s) in Google Scholar

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Description

Elezanumab (ABT-555; AE12-1Y-QL) is a human monoclonal antibody that selectively targets repulsive guidance molecule A (RGMa). Elezanumab potently inhibited RGMa mediated BMP signalling via the SMAD1/5/8 pathway, with an IC50 around 97 pM. Elezanumab promotes neuroregeneration and neuroprotection in neuronal injury and demyelination models binds N-terminal RGMa, blocks BMP signaling and lacks RGMc cross-reactivity. elezanumab has neuroregenerative and neuroprotective activities without impact on iron metabolism[1][2].

Isotype

Human IgG1 lambda1
Recommend Isotype Controls
Species

Human
In Vivo

Elezanumab (ABT-555; AE12-1Y-QL; 1-10 mg/kg; IV; once a week for 5 doses) promotes axonal regeneration and prevents retinal nerve fiber layer degeneration in the optic nerve crush and optic neuritis models (female Lewis rats)[1].
Elezanumab (0.01, 0.1, 1, 10 mg/kg; IV; once a week for 3 doses ) promotes axonal regeneration and remyelination, decreases inflammatory lesion area and improves functional recovery in the spinal targeted experimental autoimmune encephalomyelitis (EAE) model (female Lewis rats)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Lewis rat optic neuritis models[1]
Dosage: 1, 3, or 10 mg/kg
Administration: IV; once a week for 5 doses
Result: Protected against the optic nerve inflammationinduced RNFL degeneration.
Showed significant protection of the RNFL, as demonstrated by decreased reduction in RNFL thickness measured by optical coherence tomography (OCT) with 10 mg/kg
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Elezanumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 lambda2
Biological Activity
  • Immobilized Human RGMA Protein (His Tag) can bind Elezanumab. The EC50 for this effect is 2.09 ng/mL.
Purity & Documentation
References
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Elezanumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Elezanumab1791416-49-3ABT-555 AE12-1Y-QL Anti-RGMA Reference Antibody (elezanumab)ABT555ABT 555TGF-beta/SmadTransforming growth factor betarepulsive guidance molecule ARGMaBMPSMAD1/5/8neuroregenerationneuroprotectionneuroregenerativeiron metabolismInhibitorinhibitorinhibit

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