3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles

Cat. No.: HY-142042 Purity: 99.84%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles is an inhibitor for bone morphogenetic protein 2 (BMP2) with an IC₅₀ of 2.2 μM. 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles is inhibitor for mitogen-activated protein kinase 1 (MEK1). 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles exhibits anti-inflammatory and neuroprotective activity in EAE mouse model.

For research use only. We do not sell to patients.

3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles Chemical Structure

CAS No. : 287196-91-2

Size	Price	Stock	Quantity
5 mg	USD 140	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 225	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 720	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1150	Get quote	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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MEK1 MEK2 MEK5 MEK

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

285.25

Formula

C₁₁H₆F₃N₃OS

CAS No.

287196-91-2

Appearance

Solid

Color

White to off-white

SMILES

N#CC1=C(NC2=CC=CC=C2C(F)(F)F)SNC1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (876.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5057 mL	17.5285 mL	35.0570 mL
5 mM	0.7011 mL	3.5057 mL	7.0114 mL
10 mM	0.3506 mL	1.7528 mL	3.5057 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.84%

Select Batch:

Data Sheet (275 KB) SDS (251 KB)

COA (253 KB) HNMR (257 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Arnon KARNI, Small organic molecules for use in the treatment of neuroinflammatory disorders. WO2018198123.

[2]. Varaprasad CV, et al., Discovery of 3-hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles as potent MEK1 inhibitors. Bioorg Med Chem Lett. 2006 Aug 1;16(15):3975-80. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5057 mL	17.5285 mL	35.0570 mL	87.6424 mL
	5 mM	0.7011 mL	3.5057 mL	7.0114 mL	17.5285 mL
	10 mM	0.3506 mL	1.7528 mL	3.5057 mL	8.7642 mL
	15 mM	0.2337 mL	1.1686 mL	2.3371 mL	5.8428 mL
	20 mM	0.1753 mL	0.8764 mL	1.7528 mL	4.3821 mL
	25 mM	0.1402 mL	0.7011 mL	1.4023 mL	3.5057 mL
	30 mM	0.1169 mL	0.5843 mL	1.1686 mL	2.9214 mL
	40 mM	0.0876 mL	0.4382 mL	0.8764 mL	2.1911 mL
	50 mM	0.0701 mL	0.3506 mL	0.7011 mL	1.7528 mL
	60 mM	0.0584 mL	0.2921 mL	0.5843 mL	1.4607 mL
	80 mM	0.0438 mL	0.2191 mL	0.4382 mL	1.0955 mL
	100 mM	0.0351 mL	0.1753 mL	0.3506 mL	0.8764 mL