2. Neuronal Signaling
  3. AAK1
  4. BMT-124110

BMT-124110 is a potent, selective AAK1 inhibitor with an IC50 of 0.9 nM. BMT-124110 shows antinociceptive activity. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50s of 17 and 99 nM, respectively.

For research use only. We do not sell to patients.

BMT-124110 Chemical Structure

BMT-124110 Chemical Structure

CAS No. : 1679371-59-5

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Based on 1 publication(s) in Google Scholar

BMT-124110 Related Antibodies

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Description

BMT-124110 is a potent, selective AAK1 inhibitor with an IC50 of 0.9 nM. BMT-124110 shows antinociceptive activity. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50s of 17 and 99 nM, respectively[1].

In Vitro

BMT-124110 shows a cellular IC50 of 3.2±1.4 nM for AAK1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BMT-124110 Related Antibodies
In Vivo

BMT-124110 is added directly onto the spinal corevd by microiontophoresis, leading to reduction in windup-induced activity in 10 of 14 animals[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

369.46

Formula

C21H27N3O3
CAS No.
SMILES

CC(NC1=CC2=C(COC3=CC(OC[C@@](C)(N)CC(C)C)=CC=C32)C=N1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BMT-124110 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMT-1241101679371-59-5BMT124110BMT 124110AAK1Adaptor-associated Kinase 1AP2-associated kinase 1neuropathicpainchronicconstrictioninjuryCCIBIKEGAKInhibitorinhibitorinhibit

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