2. TGF-beta/Smad
  3. TGF-β Receptor
  4. LDN193189

LDN193189 (DM-3189) (GMP) is LDN193189 (HY-12071) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. LDN193189 is selective BMP type I receptor inhibitor.

For research use only. We do not sell to patients.

LDN193189 Chemical Structure

LDN193189 Chemical Structure

CAS No. : 1062368-24-4

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Based on 12 publication(s) in Google Scholar

Other Forms of LDN193189:

LDN193189 Related Antibodies

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ALK1 ALK2 ALK3 ALK4 ALK5 ALK6 ALK7 TGFβR2 ACVR2A ACVR2B

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Description

LDN193189 (DM-3189) (GMP) is LDN193189 (HY-12071) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. LDN193189 is selective BMP type I receptor inhibitor[1][2].

In Vitro

LDN193189 (GMP) (250 nM; 0-7 d) induces human pluripotent stem cells (hPSC) directly differentiates into midbrain dopamine neurons (mDA)[1].
LDN193189 (GMP) (200 nM) induces the generation of glucose-responsive β cells from hPSCs in vitro[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LDN193189 Related Antibodies
Molecular Weight

406.48

Formula

C25H22N6
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

C1(C2=C3N=CC(C4=CC=C(N5CCNCC5)C=C4)=CN3N=C2)=CC=NC6=CC=CC=C16
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LDN193189 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LDN193189 (GMP)1062368-24-4DM-3189 (GMP)TGF-β ReceptorTransforming growth factor beta receptorsbone morphogenetic protein (BMP)BMP I receptortranscriptionALK2ALK3bone morphogenetic protein signallingfibrodysplasia ossificans progressivaInhibitorinhibitorinhibit

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LDN193189
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HY-12071G
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