2. Cell Cycle/DNA Damage Neuronal Signaling
  3. Cyclin G-associated Kinase (GAK) AAK1
  4. BMT-090605 hydrochloride

BMT-090605 hydrochloride is a potent, selective the adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC50 value of 0.6 nM. BMT-090605 hydrochloride shows antinociceptive activity. BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively. BMT-090605 hydrochloride can be used for the research of neuropathic pain.

For research use only. We do not sell to patients.

BMT-090605 hydrochloride Chemical Structure

BMT-090605 hydrochloride Chemical Structure

CAS No. : 2231664-45-0

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Based on 1 publication(s) in Google Scholar

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BMT-090605 hydrochloride Related Antibodies

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Description

BMT-090605 hydrochloride is a potent, selective the adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC50 value of 0.6 nM. BMT-090605 hydrochloride shows antinociceptive activity. BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively. BMT-090605 hydrochloride can be used for the research of neuropathic pain[1].

IC50 & Target

IC50: 0.6 nM (AAK1); 45 nM (BIKE); 60 nM (GAK)[1]
In Vitro

BMT-090605 hydrochloride shows AAK1inhibitory activity with an IC50 of 0.63 nM[1].
BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BMT-090605 hydrochloride Related Antibodies
In Vivo

BMT-090605 hydrochloride(intrathecal; 0.3-3 µg/rat) causes antinociception by inhibiting AAK1 in the spinal cord[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (chronic constriction injury (CCI) model)[1]
Dosage: 0.3-3 µg/rat
Administration: Intrathecal
Result: Caused a dose-dependent reduction in thermal hyperalgesia.
Molecular Weight

400.90

Formula

C21H25ClN4O2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

N#CC1=C(OC[C@@H](N)CC(C)C)C=C(C(C2=CC=NC(C)=C32)=C1)N(C)C3=O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 31.25 mg/mL (77.95 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4944 mL 12.4719 mL 24.9439 mL
5 mM 0.4989 mL 2.4944 mL 4.9888 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4944 mL 12.4719 mL 24.9439 mL 62.3597 mL
5 mM 0.4989 mL 2.4944 mL 4.9888 mL 12.4719 mL
10 mM 0.2494 mL 1.2472 mL 2.4944 mL 6.2360 mL
15 mM 0.1663 mL 0.8315 mL 1.6629 mL 4.1573 mL
20 mM 0.1247 mL 0.6236 mL 1.2472 mL 3.1180 mL
25 mM 0.0998 mL 0.4989 mL 0.9978 mL 2.4944 mL
30 mM 0.0831 mL 0.4157 mL 0.8315 mL 2.0787 mL
40 mM 0.0624 mL 0.3118 mL 0.6236 mL 1.5590 mL
50 mM 0.0499 mL 0.2494 mL 0.4989 mL 1.2472 mL
60 mM 0.0416 mL 0.2079 mL 0.4157 mL 1.0393 mL
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BMT-090605 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMT-0906052231664-45-0BMT090605BMT 090605Cyclin G-associated Kinase (GAK)AAK1Auxilin 2Adaptor-associated Kinase 1AP2-associated kinase 1adapter protein-2 associated kinase 1 (AAK1)neuropathicpainchronicconstrictioninjuryCCIBMP-2-inducible protein kinase (BIKE)Cyclin G-associated kinase (GAK)Inhibitorinhibitorinhibit

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