ER 50891 quarterhydrate

Cat. No.: HY-108531A Purity: 99.86%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

ER 50891 quarterhydrate is a potent antagonist of retinoic acid receptor α(RARα). ER 50891 quarterhydrate significantly attenuates ATRA's inhibitive effects on BMP 2-induced osteoblastogenesis.

For research use only. We do not sell to patients.

ER 50891 quarterhydrate Chemical Structure

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of ER 50891 quarterhydrate:

ER 50891 Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

ER 50891 quarterhydrate is a potent antagonist of retinoic acid receptor α(RARα). ER 50891 quarterhydrate significantly attenuates ATRA's inhibitive effects on BMP 2-induced osteoblastogenesis^[1].

IC₅₀ & Target

RARα^[1]

Molecular Weight

437.02

Formula

C₂₉H₂₄N₂O₂.1/4H₂O

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(O)C1=CC=C(C2=CC=C(C3=NC4=C(C(C)C)C=CC=C4C(C5=CC=CC=C5)=C3)N2)C=C1.[1/4].O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (57.21 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2882 mL	11.4411 mL	22.8822 mL
5 mM	0.4576 mL	2.2882 mL	4.5764 mL
10 mM	0.2288 mL	1.1441 mL	2.2882 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.86%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (254 KB) HNMR (276 KB) LCMS (97 KB) Elemental Analysis Report (112 KB)

Handling Instructions (2659 KB)

References

[1]. Batran RZ, et al. New quinolone derivatives as neuropeptide S receptor antagonists: Design, synthesis, homology modeling, dynamic simulations and modulation of Gq/Gs signaling pathways. Bioorg Chem. 2021;111:104817. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2882 mL	11.4411 mL	22.8822 mL	57.2056 mL
	5 mM	0.4576 mL	2.2882 mL	4.5764 mL	11.4411 mL
	10 mM	0.2288 mL	1.1441 mL	2.2882 mL	5.7206 mL
	15 mM	0.1525 mL	0.7627 mL	1.5255 mL	3.8137 mL
	20 mM	0.1144 mL	0.5721 mL	1.1441 mL	2.8603 mL
	25 mM	0.0915 mL	0.4576 mL	0.9153 mL	2.2882 mL
	30 mM	0.0763 mL	0.3814 mL	0.7627 mL	1.9069 mL
	40 mM	0.0572 mL	0.2860 mL	0.5721 mL	1.4301 mL
	50 mM	0.0458 mL	0.2288 mL	0.4576 mL	1.1441 mL