E-selectin

By Targets:	E-Selectin (2) P-selectin (3) Endogenous Metabolite (2) Integrin (3) NF-κB (1) TNF Receptor (1) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (3) Inflammation/Immunology (5) Neurological Disease (1)

Targets Recommended: E-Selectin P-selectin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100226

A-205804	Integrin	Inflammation/Immunology
A-205804 is an orally bioavailable, potent and selective lead inhibitor of *E-selectin* and ICAM-1 expression, with an IC₅₀ of 20 nM and 25 nM for E-selectin and ICAM-1, respectively. A-205804 can be used in the research of chronic inflammatory diseases .

HY-106139

Bimosiamose 2 Publications Verification TBC-1269	P-selectin	Inflammation/Immunology
Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC₅₀s of 88 μM, 20 μM, and 86 μM for *E-selectin, P-selectin, and L-selectin*, respectively. Bimosiamose has anti-inflammatory effects .

HY-U00003

ICAM-1-IN-1	Integrin	Inflammation/Immunology
ICAM-1-IN-1 is a potent and selective inhibitor of *E-selectin* and ICAM-1 with IC₅₀ values of 7 and 5 nM, respectively.

HY-P990847

*Anti-E-Selectin* Antibody (CL2)**	Others E-Selectin	Others
Anti-E-Selectin Antibody (CL2) is a kind of mouse IgG2a, κ chimeric antibody, targeting to human *E-Selectin. The recommend isotype control of Anti-E-Selectin* Antibody (CL2): Mouse IgG2a kappa, Isotype Control (HY-P99978).

HY-106139A

Bimosiamose disodium TBC-1269Z	P-selectin	Inflammation/Immunology
Bimosiamose disodium (TBC-1269Z) is a nonoligosaccharide pan-selectin inhibitor with IC₅₀s of 88 μM, 20 μM, and 86 μM for *E-selectin, P-selectin, and L-selectin*, respectively. Bimosiamose disodium has anti-inflammatory effects .

HY-160072

Fmoc-NH-PEG2-NHS ester	Others	Cancer
Fmoc-NH-PEG2-NHS ester is an intermediate used in the synthesis of E-selectin antagonists ^{[1] ^.}

HY-161646

*P-selectin* antagonist 1**	P-selectin	Cardiovascular Disease
P-selectin antagonist 1 (Compound 11b) is an antagonist for pan-selectin (IC₅₀ is 82 μM) and E-selectin (K_D is 0.91 μM) .

HY-125475

Rivipansel GMI-1070	E-Selectin Others	Cardiovascular Disease
Rivipansel (GMI-1070) is a potent *E-selectin* antagonist. Rivipansel prevents interaction between leukocytes and vascular endothelium. Rivipansel has the potential for the research of sickle cell vaso-occlusive crisis .

HY-E70303

Fucosyltransferase 6 FUT6	Endogenous Metabolite	Cancer
Fucosyltransferase 6 is a fucosyltransferase that mediates the expression of the tetrasaccharide Sialyl-Lewis x (sLex, CD15s) on the surface of leukocytes. sLex participates in E-selectin-mediated leukocyte rolling and is related to the migration of leukocytes out of blood vessels .

HY-N8903

Mumefural	Integrin NF-κB Toll-like Receptor (TLR) TNF Receptor	Cardiovascular Disease Neurological Disease
Mumefural is a bioactive component of the processed fruit of Prunus mume Sieb. Mumefural inhibits platelet aggregation. Mumefural shows anti-thrombotic effects and ameliorates cognitive impairment .

HY-W020790

Sialyl-Lewis X sLeX	Endogenous Metabolite	Inflammation/Immunology
Sialyl-Lewis X (sLeX) is a sialylated fucosylated tetrasaccharide, an endogenous antigen. Sialyl-Lewis X is a high-affinity ligand for selectins (E-, P-, and L-selectin) . Sialyl-Lewis X binds to ELAM-1 and CD62 and has the ability?to inhibits CD62-mediated neutrophil recruitment to sites of inflammation .

Cat. No.	Product Name	Type

HY-158457

A2[3]G1 N-glycan N/A	Carbohydrates
A2[3]G1 N-glycan (N/A) is a Lewis sugar. SLeX is a ligand for the cell adhesion molecule E-selectin, which is specifically expressed at sites of inflammatory lesions. Designing SLeX-polysaccharide conjugates to deliver drugs to inflammatory lesions .

HY-158459

A2G2F2 glycan A2G2F2(a1-3) glycan	Carbohydrates
A2G2F2 glycan (A2G2F2(a1-3) glycan) is a Lewis X polysaccharide containing two Lewis X epitopes and is a symmetric N-glycan. SLeX is a ligand for the cell adhesion molecule E-selectin, which is specifically expressed at sites of inflammatory lesions. Designing SLeX-polysaccharide conjugates to deliver drugs to inflammatory lesions .

HY-158458

A2[3]G1F1(α-1-3) glycan A2[3]G1F1(a1-3) glycan	Carbohydrates
A2[3]G1F1(α-1-3) glycan (A2[3]G1F1(a1-3) glycan) is an asymmetric Lewis X polysaccharide and N-glycan. SLeX is a ligand for the cell adhesion molecule E-selectin, which is specifically expressed at sites of inflammatory lesions. Designing SLeX-polysaccharide conjugates to deliver drugs to inflammatory lesions .

HY-158495

A2 glycan (G0), 2-AA labelled A2 N-linked oligosaccharide, 2-AA labelled	Carbohydrates
A2[3]G1 & A2[6]G1 glycan (G1), 2-AB labeled Lewis sugar. SLeX is a ligand for the cell adhesion molecule E-selectin (E-selectin), which is specifically expressed at sites of inflammatory lesions. Designing SLeX-polysaccharide conjugates to deliver drugs to inflammatory lesions .

HY-158522

A2[3]G1 & A2[6]G1 glycan (G1), 2-AB labelled A2[3]G1 & A2[6]G1 N-linked oligosaccharide, 2-AB labelled	Carbohydrates
A2[3]G1 & A2[6]G1 glycan (G1), 2-AB labeled Lewis sugar. SLeX is a ligand for the cell adhesion molecule E-selectin (E-selectin), which is specifically expressed at sites of inflammatory lesions. Designing SLeX-polysaccharide conjugates to deliver drugs to inflammatory lesions .

Cat. No.	Product Name	Target	Research Area

HY-P990847

*Anti-E-Selectin* Antibody (CL2)**	Inhibitory Antibodies E-Selectin	Others
Anti-E-Selectin Antibody (CL2) is a kind of mouse IgG2a, κ chimeric antibody, targeting to human *E-Selectin. The recommend isotype control of Anti-E-Selectin* Antibody (CL2): Mouse IgG2a kappa, Isotype Control (HY-P99978).

HY-P990247

*Anti-Mouse E-selectin/CD62E Antibody (9A9)*	Inhibitory Antibodies	Others
Anti-Mouse E-selectin/CD62E Antibody (9A9) is a rat-derived IgG2b type antibody inhibitor, targeting to mouse E-selectin/CD62E.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W020790

Sialyl-Lewis X sLeX	Structural Classification Polysaccharides Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Saccharides	Endogenous Metabolite
Sialyl-Lewis X (sLeX) is a sialylated fucosylated tetrasaccharide, an endogenous antigen. Sialyl-Lewis X is a high-affinity ligand for selectins (E-, P-, and L-selectin) . Sialyl-Lewis X binds to ELAM-1 and CD62 and has the ability?to inhibits CD62-mediated neutrophil recruitment to sites of inflammation .

Species:	Human (5) Mouse (3) Rat (2) Cynomolgus (2)
Tag:	His (7) Tag Free (1) Avi (2) Fc (5)
Source:	HEK293 (12)

Cat. No.	Compare	Product Name	Species	Source

HY-P75220

	E-selectin/CD62E Protein, Cynomolgus (HEK293, His) E-selectin; ELAM-1; LECAM2; CD63E; SELE	Cynomolgus	HEK293
	The E-selectin/CD62E Protein, belonging to the selectin/LECAM family, plays a crucial role in mediating cell adhesion processes, particularly interactions between leukocytes and endothelial cells. As a member of this family, E-selectin likely shares conserved features, emphasizing its significance in cellular adhesion. Its study contributes to understanding inflammatory responses, immune cell trafficking, and potential therapeutic interventions. Further exploration of E-selectin/CD62E's role promises insights into its contributions to immune surveillance, inflammation, and broader cellular processes in both normal physiology and pathology. E-selectin/CD62E Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived E-selectin/CD62E protein, expressed by HEK293, with C-His labeled tag. The total length of E-selectin/CD62E Protein, Cynomolgus (HEK293, His) is 535 a.a., with molecular weight of 95-115 kDa.

HY-P73042

	E-Selectin/CD62E Protein, Mouse (HEK293, His) E-selectin; ELAM-1; LECAM2; CD62E; SELE	Mouse	HEK293
	E-Selectin/CD62E protein, a cell-surface glycoprotein, mediates the adhesion of blood neutrophils to cytokine-activated endothelium through interaction with SELPLG/PSGL1. It also potentially contributes to capillary morphogenesis and interacts with SELPLG/PSGL1 and PODXL2. These multifaceted interactions highlight E-Selectin's role in cell adhesion and its potential influence on vascular development. E-Selectin/CD62E Protein, Mouse (HEK293, His) is the recombinant mouse-derived E-Selectin/CD62E protein, expressed by HEK293 , with C-His, C-10*His labeled tag.

HY-P73044

	E-Selectin/CD62E Protein, Rat (HEK293, His) E-selectin; ELAM-1; LECAM2; CD62E; SELE	Rat	HEK293
	The E-selectin/CD62E protein is a cell surface glycoprotein that critically mediates immune adhesion by promoting neutrophil adhesion to cytokine-activated endothelial cells through the SELPLG/PSGL1 interaction. It may also contribute to capillary morphogenesis and interact with SELPLG/PSGL1 and PODXL2 via the sialyl Lewis X epitope regardless of SELPLG sulfation. E-Selectin/CD62E Protein, Rat (HEK293, His) is the recombinant rat-derived E-Selectin/CD62E protein, expressed by HEK293 , with C-His labeled tag. The total length of E-Selectin/CD62E Protein, Rat (HEK293, His) is 473 a.a., with molecular weight of ~75-96 kDa.

HY-P74161

	E-Selectin/CD62E Protein, Human (HEK293, His-Fc) E-selectin; ELAM-1; LECAM2; CD62E; SELE	Human	HEK293
	E-selectin/CD62E Protein, a cell-surface glycoprotein, crucially mediates immunoadhesion by interacting with SELPLG/PSGL1 for the adhesion of neutrophils to cytokine-activated endothelium. It also potentially influences capillary morphogenesis and interacts with SELPLG/PSGL1 and PODXL2 through the sialyl Lewis X epitope, independently of SELPLG sulfation. E-Selectin/CD62E Protein, Human (HEK293, His-Fc) is the recombinant human-derived E-Selectin/CD62E protein, expressed by HEK293 , with C-hFc, C-His labeled tag. The total length of E-Selectin/CD62E Protein, Human (HEK293, His-Fc) is 535 a.a., with molecular weight of 140-150 kDa.

HY-P72661

	E-selectin/CD62E Protein, Human (HEK293, His) E-selectin; ELAM-1; LECAM2; CD62E; SELE	Human	HEK293
	E-selectin/CD62E Protein, a cell-surface glycoprotein, crucially mediates immunoadhesion by interacting with SELPLG/PSGL1 for the adhesion of neutrophils to cytokine-activated endothelium. It also potentially influences capillary morphogenesis and interacts with SELPLG/PSGL1 and PODXL2 through the sialyl Lewis X epitope, independently of SELPLG sulfation. E-selectin/CD62E Protein, Human (HEK293, His) is the recombinant human-derived E-selectin/CD62E protein, expressed by HEK293 , with C-6*His labeled tag. The total length of E-selectin/CD62E Protein, Human (HEK293, His) is 535 a.a., with molecular weight of ~104 kDa.

HY-P74160

	E-Selectin/CD62E Protein, Mouse (HEK293) E-selectin; ELAM-1; LECAM2; CD62E; SELE	Mouse	HEK293
	E-Selectin/CD62E protein, a cell-surface glycoprotein, mediates the adhesion of blood neutrophils to cytokine-activated endothelium through interaction with SELPLG/PSGL1. It also potentially contributes to capillary morphogenesis and interacts with SELPLG/PSGL1 and PODXL2. These multifaceted interactions highlight E-Selectin's role in cell adhesion and its potential influence on vascular development. E-Selectin/CD62E Protein, Mouse (HEK293) is the recombinant mouse-derived E-Selectin/CD62E protein, expressed by HEK293 , with tag free.

HY-P75221

	E-selectin/CD62E Protein, Cynomolgus (HEK293, hFc) E-selectin; ELAM-1; LECAM2; CD62E; SELE	Cynomolgus	HEK293
	The E-selectin/CD62E protein belongs to the selectin/LECAM family and plays a crucial role in mediating cell adhesion processes, particularly the interaction between leukocytes and endothelial cells.As a member of this family, E-selectin may have conserved characteristics, underscoring its importance in cell adhesion.E-selectin/CD62E Protein, Cynomolgus (HEK293, hFc) is the recombinant cynomolgus-derived E-selectin/CD62E protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P73041

	E-Selectin/CD62E Protein, Mouse (HEK293, Fc) E-selectin; ELAM-1; LECAM2; CD62E; SELE	Mouse	HEK293
	E-Selectin/CD62E protein, a cell-surface glycoprotein, mediates the adhesion of blood neutrophils to cytokine-activated endothelium through interaction with SELPLG/PSGL1. It also potentially contributes to capillary morphogenesis and interacts with SELPLG/PSGL1 and PODXL2. These multifaceted interactions highlight E-Selectin's role in cell adhesion and its potential influence on vascular development. E-Selectin/CD62E Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived E-Selectin/CD62E protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P73043

	E-Selectin/CD62E Protein, Rat (HEK293, Fc) E-selectin; ELAM-1; LECAM2; CD62E; SELE	Rat	HEK293
	The E-selectin/CD62E protein is a cell surface glycoprotein that critically mediates immune adhesion by promoting neutrophil adhesion to cytokine-activated endothelial cells through the SELPLG/PSGL1 interaction.It may also contribute to capillary morphogenesis and interact with SELPLG/PSGL1 and PODXL2 via the sialyl Lewis X epitope regardless of SELPLG sulfation.E-Selectin/CD62E Protein, Rat (HEK293, Fc) is the recombinant rat-derived E-Selectin/CD62E protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P74162

	E-Selectin/CD62E Protein, Human (HEK293, Fc) E-selectin; ELAM-1; LECAM2; CD62E; SELE	Human	HEK293
	E-selectin/CD62E Protein, a cell-surface glycoprotein, crucially mediates immunoadhesion by interacting with SELPLG/PSGL1 for the adhesion of neutrophils to cytokine-activated endothelium. It also potentially influences capillary morphogenesis and interacts with SELPLG/PSGL1 and PODXL2 through the sialyl Lewis X epitope, independently of SELPLG sulfation. E-Selectin/CD62E Protein, Human (HEK293, Fc) is the recombinant human-derived E-Selectin/CD62E protein, expressed by HEK293 , with C-hFc labeled tag. The total length of E-Selectin/CD62E Protein, Human (HEK293, Fc) is 535 a.a., with molecular weight of ~85.4 kDa.

HY-P78437

	E-Selectin/CD62E Protein, Human (HEK293, His-Avi) CD62E; ELAM; ELAM1; ESEL; E-selectin; LECAM2; SELE; selectin E; RP1-117P20.2	Human	HEK293
	E-selectin/CD62E Protein, a cell-surface glycoprotein, crucially mediates immunoadhesion by interacting with SELPLG/PSGL1 for the adhesion of neutrophils to cytokine-activated endothelium. It also potentially influences capillary morphogenesis and interacts with SELPLG/PSGL1 and PODXL2 through the sialyl Lewis X epitope, independently of SELPLG sulfation. E-Selectin/CD62E Protein, Human (HEK293, His-Avi) is the recombinant human-derived E-Selectin/CD62E protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of E-Selectin/CD62E Protein, Human (HEK293, His-Avi) is 535 a.a., with molecular weight of 80-100 kDa.

HY-P78119

	E-selectin/CD62E Protein, Human (Biotinylated, HEK293, His-Avi) CD62E; ELAM; ELAM1; ESEL; E-selectin; LECAM2; SELE; selectin E; RP1-117P20.2	Human	HEK293
	E-selectin/CD62E Protein, a cell-surface glycoprotein, crucially mediates immunoadhesion by interacting with SELPLG/PSGL1 for the adhesion of neutrophils to cytokine-activated endothelium. It also potentially influences capillary morphogenesis and interacts with SELPLG/PSGL1 and PODXL2 through the sialyl Lewis X epitope, independently of SELPLG sulfation. E-selectin/CD62E Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived E-selectin/CD62E protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of E-selectin/CD62E Protein, Human (Biotinylated, HEK293, His-Avi) is 535 a.a., with molecular weight of 80-100 kDa.

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