2. Signaling Pathways
  3. Immunology/Inflammation
  4. E-Selectin

E-Selectin

E-Selectin; CD62E; ELAM1; LECAM-2

E-selectin (CD62E) is an adhesion molecule expressed on endothelial cells. The E-selectin molecule consists of five unique components, including an amino-terminal lectin domain that interacts with ligands, an epidermal growth factor (EGF)-like domain, a complement regulatory-like domain, a transmembrane domain, and a C-terminal cytoplasmic tail. E-selectin expression is induced by inflammatory stimuli and oxidative stress, and its expression levels correlate with endothelial cell damage. Inhibition of E-selectin may reduce thrombosis, vascular leakage, and cancer metastasis[1].

E-Selectin Related Products (4):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-158459
    A2G2F2 glycan
    A2G2F2 glycan (A2G2F2(a1-3) glycan) is a Lewis X polysaccharide containing two Lewis X epitopes and is a symmetric N-glycan. SLeX is a ligand for the cell adhesion molecule E-selectin, which is specifically expressed at sites of inflammatory lesions. Designing SLeX-polysaccharide conjugates to deliver drugs to inflammatory lesions.
    A2G2F2 glycan
  • HY-P990847
    Anti-E-Selectin Antibody (CL2)
    		Inhibitor
    Anti-E-Selectin Antibody (CL2) is a kind of mouse IgG2a, κ chimeric antibody, targeting to human E-Selectin. The recommend isotype control of Anti-E-Selectin Antibody (CL2): Mouse IgG2a kappa, Isotype Control (HY-P99978).
    Anti-E-Selectin Antibody (CL2)
  • HY-125475
    Rivipansel
    		Antagonist
    Rivipansel (GMI-1070) is a potent E-selectin antagonist. Rivipansel prevents interaction between leukocytes and vascular endothelium. Rivipansel has the potential for the research of sickle cell vaso-occlusive crisis.
    Rivipansel
  • HY-P10770
    P-ESBP-DOX
    		Inhibitor
    P-ESBP-DOX is a HPMA copolymer-drug conjugate, which is consistituted of the E-selectin binding peptide and the Doxorubicin (HY-15142). P-ESBP-DOX exhibits cytotoxicity against TNFα-activated human vascular endothelial cells IVECs with an IC50 of 0.28 μM. P-ESBP-DOX can be used in research about tumor vasculature.
    P-ESBP-DOX