Search Result

Pathways Recommended:	MAPK/ERK Pathway

Results for "

ERK/ROS

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ERK (12) ROS Kinase (4) Akt (5) Amyloid-β (2) Apoptosis (11) Atg8/LC3 (2) Autophagy (8) Bacterial (2) Bcl-2 Family (3) Calcium Channel (1) Caspase (1) CDK (3) Chemerin Receptor (2) COX (1) Cyclin G-associated Kinase (GAK) (1) EGFR (1) Ferroptosis (2) Fungal (2) Glutathione S-transferase (1) HBV (1) HCV (1) HSP (1) Interleukin Related (1) JNK (2) MDM-2/p53 (1) Microtubule/Tubulin (1) mTOR (1) Necroptosis (2) NF-κB (1) P-glycoprotein (1) p38 MAPK (2) p62 (2) Parasite (4) Phosphatase (1) PI3K (4) Potassium Channel (3) Reactive Oxygen Species (14) SARS-CoV (3) TNF Receptor (4) TrxR (1) VEGFR (1)
By Research Areas:	Cancer (14) Cardiovascular Disease (3) Infection (7) Inflammation/Immunology (11) Metabolic Disease (6) Neurological Disease (8)

By Targets:

ERK (12)

ROS Kinase (4)

Akt (5)

Amyloid-β (2)

Apoptosis (11)

Atg8/LC3 (2)

Autophagy (8)

Bacterial (2)

Bcl-2 Family (3)

Calcium Channel (1)

Caspase (1)

CDK (3)

Chemerin Receptor (2)

COX (1)

Cyclin G-associated Kinase (GAK) (1)

EGFR (1)

Ferroptosis (2)

Fungal (2)

Glutathione S-transferase (1)

HBV (1)

HCV (1)

HSP (1)

Interleukin Related (1)

JNK (2)

MDM-2/p53 (1)

Microtubule/Tubulin (1)

mTOR (1)

Necroptosis (2)

NF-κB (1)

P-glycoprotein (1)

p38 MAPK (2)

p62 (2)

Parasite (4)

Phosphatase (1)

PI3K (4)

Potassium Channel (3)

Reactive Oxygen Species (14)

SARS-CoV (3)

TNF Receptor (4)

TrxR (1)

VEGFR (1)

By Research Areas:

Cancer (14)

Cardiovascular Disease (3)

Infection (7)

Inflammation/Immunology (11)

Metabolic Disease (6)

Neurological Disease (8)

Inhibitors & Agonists

Peptides

Natural
Products

Targets Recommended: ROS Kinase ERK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-116807

Dihydrolipoic Acid DHLA	Reactive Oxygen Species	Neurological Disease Inflammation/Immunology
Dihydrolipoic Acid (DHLA) is an excellent antioxidant capable of scavenging almost any oxygen-centered radical . Dihydrolipoic acid exhibits anti-inflammatory properties in various diseases. Dihydrolipoic Acid exerts a preventive effect via ERK/Nrf2/HO-1/ROS/NLRP3 pathway in LPS-induced sickness behavior rats. Dihydrolipoic Acid can be used for the reaserch of depression .

HY-N8418

Cearoin	Autophagy Reactive Oxygen Species ERK Apoptosis	Cancer
Cearoin increases autophagy and apoptosis through the production of *ROS* and the activation of *ERK* .

HY-N2329

Piperlongumine Maximum Cited Publications 7 Publications Verification Piplartine	ERK Reactive Oxygen Species Autophagy Apoptosis Bacterial Ferroptosis	Infection Cardiovascular Disease Cancer
Piperlongumine is a alkaloid , possesses ant-inflammatory, antibacterial, antiangiogenic, antioxidant, antitumor, and antidiabetic activities . Piperlongumine induces ROS, and induces apoptosis in cancer cell lines . Piperlongumine shows anti-cardiac fibrosis activity, suppresses myofibroblast transformation via suppression of the ERK1/2 signaling pathway. Piperlongumin could be used in the study of migrasome .

HY-N11439

Albanol B	CDK Akt ERK Apoptosis Bacterial	Infection Neurological Disease Cancer
Albanol B is an arylbenzofuran derivative which can be isolated from mulberries. Albanol B exhibits anti-Alzheimer's disease, anti-bacterial and antioxidant activities. Albanol B inhibits cancer cells proliferation, down-regulates CDK1 expression. Albanol B also induces cell cycle arrest at G2/M and apoptosis. And Albanol B induces mitochondrial ROS production and increases the phosphorylation levels of AKT and *ERK1/2* .

HY-17587

4-Methylbenzylidene camphor 1 Publications Verification 4-MBC; Enzacamene	Apoptosis PI3K Akt ERK	Metabolic Disease
4-Methylbenzylidene camphor (4-MBC) is an endocrine disrupter that produces estrogen-like effects. 4-Methylbenzylidene camphor decreases the proliferation of human trophoblast cells and induces apoptosis. 4-Methylbenzylidene camphor activates PI3K/AKT and *ERK1/2* signaling pathways and elevates intracellular ROS production. 4-Methylbenzylidene camphor is a ultraviolet (UV) filter and may hamper normal placental formation during early pregnancy .

HY-17437A

Mefloquine hydrochloride 3 Publications Verification Mefloquin hydrochloride	Parasite SARS-CoV Autophagy Potassium Channel ROS Kinase	Infection Metabolic Disease Inflammation/Immunology Cancer
Mefloquine hydrochloride (Mefloquin hydrochloride), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor. Mefloquine hydrochloride is also a K ⁺ channel (KvQT1/minK) antagonist with an IC₅₀ of ~1 μM. Mefloquine hydrochloride can be used for malaria, systemic lupus erythematosus and cancer research .

HY-P1844

Chemerin-9 (149-157)	Chemerin Receptor Akt ERK Reactive Oxygen Species Amyloid-β	Inflammation/Immunology
Chemerin-9 (149-157) is a potent agonist of chemokine-like receptor 1 (CMKLR1) . Chemerin-9 (149-157) has anti-inflammatory activity. Chemerin-9 (149-157) stimulates phosphorylation of Akt and ERK as well as ROS production. Chemerin-9 (149-157) ameliorates Aβ_1-42-induced memory impairmen. Chemerin-9 (149-157) regulates immune responses, adipocyte differentiation, and glucose metabolism .

HY-116807R

Dihydrolipoic Acid (Standard)	Reactive Oxygen Species	Neurological Disease Inflammation/Immunology
Dihydrolipoic Acid (Standard) is the analytical standard of Dihydrolipoic Acid. This product is intended for research and analytical applications. Dihydrolipoic Acid (DHLA) is an excellent antioxidant capable of scavenging almost any oxygen-centered radical . Dihydrolipoic acid exhibits anti-inflammatory properties in various diseases. Dihydrolipoic Acid exerts a preventive effect via ERK/Nrf2/HO-1/ROS/NLRP3 pathway in LPS-induced sickness behavior rats. Dihydrolipoic Acid can be used for the reaserch of depression .

HY-121200

Azadirone	TNF Receptor Bcl-2 Family Parasite	Infection Cancer
Azadirone sensitized cancer cells to TNF-related apoptosis-inducing ligand (TRAIL) through ROS-ERK-CHOP-mediated up-regulation of DR5 and DR4 expression, down-regulation of cell survival proteins, and up-regulation of proapoptotic proteins (Bid). Azadirone has antiplasmodial activity .

HY-17437AR

Mefloquine (hydrochloride) (Standard)	Parasite SARS-CoV Autophagy Potassium Channel ROS Kinase	Infection Metabolic Disease Inflammation/Immunology Cancer
Mefloquine (hydrochloride) (Standard) is the analytical standard of Mefloquine (hydrochloride). This product is intended for research and analytical applications. Mefloquine hydrochloride (Mefloquin hydrochloride), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor. Mefloquine hydrochloride is also a K+ channel (KvQT1/minK) antagonist with an IC50 of ~1 μM. Mefloquine hydrochloride can be used for malaria, systemic lupus erythematosus and cancer research .

HY-N3071

Picrasidine I	Apoptosis Reactive Oxygen Species	Inflammation/Immunology
Picrasidine I is an anti-inflammatory and anti-osteoclastogenic dimeric alkaloid that can be isolated from Picrasma quassioides. Picrasidine I inducs cell cycle arrest, and triggers cell apoptosis by downregulats *ERK* and Akt pathways. Picrasidine I inhibits the activation of MAPKs, NF-κB and *ROS* generation, and suppresses the expression of c-Fos and NFATc1 .

HY-P4052

Pinealon	ROS Kinase	Neurological Disease
Pinealon is a 3-amino acid peptide and shows neuroprotective properties. Pinealon prevents reactive oxygen species (ROS) accumulation and suppresses the activation of ERK 1/2. Pinealon stimulates the functional activity of the main cellular elements of brain tissue, reduces the level of spontaneous cell death. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia .

HY-17587R

4-Methylbenzylidene camphor (Standard)	Apoptosis PI3K Akt ERK	Metabolic Disease
4-Methylbenzylidene camphor (Standard) is the analytical standard of 4-Methylbenzylidene camphor. This product is intended for research and analytical applications. 4-Methylbenzylidene camphor (4-MBC) is an endocrine disrupter that produces estrogen-like effects. 4-Methylbenzylidene camphor decreases the proliferation of human trophoblast cells and induces apoptosis. 4-Methylbenzylidene camphor activates PI3K/AKT and ERK1/2 signaling pathways and elevates intracellular ROS production. 4-Methylbenzylidene camphor is a ultraviolet (UV) filter and may hamper normal placental formation during early pregnancy .

HY-151802

CPUL1	TrxR	Cancer
CPUL1 is a TrxR inhibitor, which shows proliferation-inhibitory and anti-metastatic activity against A549 cells. CPUL1 influences EMT (epithelial-mesenchymal transition) via inducing ROS-mediated *ERK/JNK* signaling by inhibiting TrxR1 enzyme activity. CPUL1 in combination with α-Lipoic Acid (HY-N0492) or Dithiodipropionic acid (HY-W014395) is more effective .

HY-P1845

PACAP-38 (31-38), human, mouse, rat	ERK EGFR Reactive Oxygen Species Calcium Channel	Neurological Disease
PACAP-38 (31-38), human, mouse, rat is a PAC₁ receptor activator and increases the α-secretase activity. PACAP-38 (31-38), human, mouse, rat elevates cytosolic Ca ²⁺, increases proliferation and increases phosphorylation of extracellular regulates kinase (ERK) and the epidermal growth factor receptor (EGFR). PACAP-38 (31-38), human, mouse, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. PACAP-38 (31-38), human, mouse, rat can be used for neurotrophic and neuroprotective research .

HY-W010201

Citronellol 2 Publications Verification (±)-Citronellol; (±)-β-Citronellol	Reactive Oxygen Species ERK PI3K TNF Receptor Atg8/LC3 p62 Apoptosis Necroptosis Autophagy Fungal	Cardiovascular Disease Neurological Disease Cancer
Citronellol ((±)-Citronellol) is an orally active inducer of apoptosis. Citronellol can prevent oxidative stress, mitochondrial dysfunction, and apoptosis in the SH-SY5Y cell Parkinson's disease model induced by 6-OHDA by regulating the *ROS-NO, MAPK/ERK, and PI3K/Akt* signaling pathways. Citronellol can induce necroptosis in human lung cancer cells through the TNF-α pathway and accumulation of *ROS. Citronellol can reduce the levels of LC-3* and p62 to regulate the autophagy pathway, inhibit oxidative stress and neuroinflammation, and thus have neuroprotective effects on Parkinson's rats. Citronellol exhibits anti-fungal activity against Trichophyton rubrum by inhibiting ergosterol synthesis .

HY-W010201R

Citronellol (Standard) (±)-Citronellol (Standard); (±)-β-Citronellol (Standard)	Reactive Oxygen Species ERK PI3K TNF Receptor Atg8/LC3 p62 Apoptosis Necroptosis Autophagy Fungal	Cardiovascular Disease Neurological Disease Cancer
Citronellol (Standard) is the analytical standard of Citronellol. Citronellol (Standard) is an orally active inducer of apoptosis. Citronellol (Standard) can prevent oxidative stress, mitochondrial dysfunction, and apoptosis in the SH-SY5Y cell Parkinson's disease model induced by 6-OHDA by regulating the *ROS-NO, MAPK/ERK, and PI3K/Akt* signaling pathways. Citronellol (Standard) can induce necroptosis in human lung cancer cells through the TNF-α pathway and accumulation of *ROS. Citronellol (Standard) can reduce the levels of LC-3* and p62 to regulate the autophagy pathway, inhibit oxidative stress and neuroinflammation, and thus have neuroprotective effects on Parkinson's rats. Citronellol (Standard) exhibits anti-fungal activity against Trichophyton rubrum by inhibiting ergosterol synthesis .

HY-126390

(E/Z)-BCI NSC 150117	Phosphatase Apoptosis	Inflammation/Immunology Cancer
(E/Z)-BCI (NSC 150117) is a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory activities. (E/Z)-BCI attenuates LPS-induced inflammatory mediators and ROS production in macrophage cells via activating the Nrf2 signaling axis and inhibiting the NF-κB pathway .

HY-128463

N-tert-Butyl-α-phenylnitrone 1 Publications Verification	COX Reactive Oxygen Species	Neurological Disease Metabolic Disease Inflammation/Immunology
N-tert-Butyl-α-phenylnitrone is a nitrone-based free radical scavenger that forms nitroxide spin adducts. N-tert-Butyl-α-phenylnitrone inhibits COX2 catalytic activity. N-tert-Butyl-α-phenylnitrone has potent ROS scavenging, anti-inflammatory, neuroprotective, anti-aging and anti-diabetic activities, and can penetrate the blood-brain barrier .

HY-P1844A

Chemerin-9 (149-157) (TFA) 4 Publications Verification	Chemerin Receptor Akt ERK Reactive Oxygen Species Amyloid-β	Inflammation/Immunology
Chemerin-9 (149-157) TFA is a potent agonist of chemokine-like receptor 1 (CMKLR1) . Chemerin-9 (149-157) TFA has anti-inflammatory activity. Chemerin-9 (149-157) TFA stimulates phosphorylation of Akt and ERK as well as ROS production. Chemerin-9 (149-157) TFA ameliorates Aβ_1-42-induced memory impairmen. Chemerin-9 (149-157) TFA regulates immune responses, adipocyte differentiation, and glucose metabolism .

HY-161966

VEGFR-2-IN-52	Apoptosis Reactive Oxygen Species VEGFR	Cancer
VEGFR-2-IN-52 (compound 14d) is a potent VEGFR-2 inhibitor with an IC₅₀ value of 191.1 nM. VEGFR-2-IN-52 decreases the protein expression of p-VEGFR-2, MMP9, p-ERK1/2 and p-MEK1. VEGFR-2-IN-52 shows cytotoxicity. VEGFR-2-IN-52 induces apoptosis and cell cycle arrest at G0/G1 phase. VEGFR-2-IN-52 increases the levels of *ROS* .

HY-17437

Mefloquine 3 Publications Verification Mefloquin	Parasite Autophagy SARS-CoV Potassium Channel ROS Kinase	Infection Metabolic Disease Inflammation/Immunology Cancer
Mefloquine (Mefloquin), an orally active and potent quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor. Mefloquine is also a K ⁺ channel (KvQT1/minK) antagonist with an IC₅₀ of ~1 μM. Mefloquine can be used for malaria, systemic lupus erythematosus and cancer research .

HY-169412

MAPK-IN-3	MDM-2/p53 CDK Caspase Bcl-2 Family Reactive Oxygen Species p38 MAPK ERK JNK	Cancer
MAPK-IN-3 (Compound 4a) is an anti-proliferative agent that shows particularly strong inhibitory effects on KYSE 30, HCT 116, and HGC 27, with IC₅₀ values of 0.57 μM, 3.27 μM, and 2.28 μM, respectively. MAPK-IN-3 blocks the cell cycle via a p53-dependent mechanism and induces cell apoptosis through a p53-independent mechanism. MAPK-IN-3 downregulates the expression of cell cycle-related proteins like Cyclin D1 and cyclin B1, upregulates pro-apoptotic proteins such as cleaved PARP, cleaved caspase-7, and cleaved caspase-9, and reduces the expression of anti-apoptotic proteins like Bcl-2. Additionally, MAPK-IN-3 increases the intracellular level of *ROS* in KYSE 30 cells and upregulates the expression of members of the MAPK signaling pathway associated with *ROS, such as p-ERK, p-p38* and p-JNK .

HY-B0766

Bicyclol SY801	Autophagy Apoptosis HBV HCV HSP Reactive Oxygen Species Bcl-2 Family Glutathione S-transferase p38 MAPK NF-κB Microtubule/Tubulin ERK JNK TNF Receptor Interleukin Related CDK Cyclin G-associated Kinase (GAK) mTOR P-glycoprotein Ferroptosis	Infection Inflammation/Immunology Cancer
Bicyclol (SY801) is an orally active derivative of the traditional Chinese medicine Schisandra chinensis, which has antiviral, anti-inflammatory, immunomodulatory, antioxidant, anti-steatosis, anti-fibrotic and anti-tumor activities. Bicyclol regulates the expression of heat shock proteins and plays an anti-apoptosis role in hepatocytes. Bicyclol reduces the activation of NF-κB and the levels of inflammatory factors in hepatocytes infected with hepatitis C virus (HCV) by inhibiting the activation of the *ROS-MAPK-NF-κB* pathway, and prevents ferroptosis in acute liver injury. Bicyclol can change the expression of Mdr-1, GSH/GST and Bcl-2, increase the intracellular concentration of anticancer drugs, and sensitize drug-resistant cells to anticancer drugs. Bicyclol inhibits the proliferation of human malignant hepatoma cells by regulating the PI3K/AKT pathway and the *Ras/Raf/MEK/ERK* pathway. Bicyclol can be used in the study of chronic hepatitis, acute liver injury, nonalcoholic fatty liver disease, liver fibrosis and hepatocellular carcinoma .

Cat. No.	Product Name	Target	Research Area