2. Autophagy NF-κB Metabolic Enzyme/Protease Immunology/Inflammation MAPK/ERK Pathway Stem Cell/Wnt Apoptosis
  3. Autophagy Reactive Oxygen Species ERK Apoptosis
  4. Cearoin

Cearoin increases autophagy and apoptosis through the production of ROS and the activation of ERK.

For research use only. We do not sell to patients.

Cearoin Chemical Structure

Cearoin Chemical Structure

CAS No. : 52811-37-7

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Based on 1 publication(s) in Google Scholar

Cearoin Related Antibodies

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ERK ERK1 ERK2 ERK5 ERK8

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Description

Cearoin increases autophagy and apoptosis through the production of ROS and the activation of ERK[1].

IC50 & Target[1]

ERK

 

ROS

 

Autophagy

 

Apoptosis

 

In Vitro

Cearoin (10-80 μM) induces cell death in a dose-dependent manner[1].
Cearoin (10-80 μM) increases the phosporylation of ERK in SH-SY5Y cells[1].
Cearoin (5-80 μM) increases the conversion of LC3B-I to LC3B-II in SH-SY5Y cells. The expression of LC3B-II is a good marker for autophagosome formation in the autophagy process[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cearoin Related Antibodies

Cell Viability Assay[1]

Cell Line: Human neuroblastoma SH-SY5Y cells
Concentration: 0, 1, 5, 10, 20, 40, or 80 μM
Incubation Time: 6 or 12 hours
Result: Significantly decreased cell viability from 10 μM in a dose-dependent manner. Treatment with 40 μM for 12 h induced about 50% loss in cell viability in SH-SY5Y cells.

Western Blot Analysis[1]

Cell Line: Human neuroblastoma SH-SY5Y cells
Concentration: 0, 5, 10, 20, 40, or 80 μM
Incubation Time: 12 hours
Result: Increased ERK phosphorylation in a dose-dependent manner, whereas it did not alter JNK phosphorylation.
Induced the formation of LC3B-II in a dose dependent manner.
Molecular Weight

244.24

Formula

C14H12O4
CAS No.
Appearance

Solid

Color

Light yellow to green yellow

SMILES

O=C(C1=CC(O)=C(OC)C=C1O)C2=CC=CC=C2
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (204.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0943 mL 20.4717 mL 40.9433 mL
5 mM 0.8189 mL 4.0943 mL 8.1887 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Purity: ≥98.0%

COA (249 KB) HNMR (192 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0943 mL 20.4717 mL 40.9433 mL 102.3583 mL
5 mM 0.8189 mL 4.0943 mL 8.1887 mL 20.4717 mL
10 mM 0.4094 mL 2.0472 mL 4.0943 mL 10.2358 mL
15 mM 0.2730 mL 1.3648 mL 2.7296 mL 6.8239 mL
20 mM 0.2047 mL 1.0236 mL 2.0472 mL 5.1179 mL
25 mM 0.1638 mL 0.8189 mL 1.6377 mL 4.0943 mL
30 mM 0.1365 mL 0.6824 mL 1.3648 mL 3.4119 mL
40 mM 0.1024 mL 0.5118 mL 1.0236 mL 2.5590 mL
50 mM 0.0819 mL 0.4094 mL 0.8189 mL 2.0472 mL
60 mM 0.0682 mL 0.3412 mL 0.6824 mL 1.7060 mL
80 mM 0.0512 mL 0.2559 mL 0.5118 mL 1.2795 mL
100 mM 0.0409 mL 0.2047 mL 0.4094 mL 1.0236 mL
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Cearoin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cearoin52811-37-7AutophagyReactive Oxygen SpeciesERKApoptosisExtracellular signal regulated kinasesneuroblastomaautophagyreactiveoxygenspeciesSH-SY5YInhibitorinhibitorinhibit

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