2. GPCR/G Protein PI3K/Akt/mTOR Stem Cell/Wnt MAPK/ERK Pathway Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Neuronal Signaling
  3. Chemerin Receptor Akt ERK Reactive Oxygen Species Amyloid-β
  4. Chemerin-9 (149-157) (TFA)

Chemerin-9 (149-157) TFA is a potent agonist of chemokine-like receptor 1 (CMKLR1) . Chemerin-9 (149-157) TFA has anti-inflammatory activity. Chemerin-9 (149-157) TFA stimulates phosphorylation of Akt and ERK as well as ROS production. Chemerin-9 (149-157) TFA ameliorates Aβ1-42-induced memory impairmen. Chemerin-9 (149-157) TFA regulates immune responses, adipocyte differentiation, and glucose metabolism.

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Chemerin-9 (149-157) (TFA) Chemical Structure

Chemerin-9 (149-157) (TFA) Chemical Structure

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10 mM * 1 mL in Water USD 583 In-stock
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1 mg USD 120 In-stock
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10 mg USD 450 In-stock
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Based on 4 publication(s) in Google Scholar

Other Forms of Chemerin-9 (149-157) (TFA):

Chemerin-9 (149-157) (TFA) Related Antibodies

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Description

Chemerin-9 (149-157) TFA is a potent agonist of chemokine-like receptor 1 (CMKLR1) . Chemerin-9 (149-157) TFA has anti-inflammatory activity. Chemerin-9 (149-157) TFA stimulates phosphorylation of Akt and ERK as well as ROS production. Chemerin-9 (149-157) TFA ameliorates Aβ1-42-induced memory impairmen. Chemerin-9 (149-157) TFA regulates immune responses, adipocyte differentiation, and glucose metabolism[1][2][3][4].

In Vitro

Chemerin-9 (149-157) TFA (0.1 nM; 24 h; cardiac fibroblasts) stimulates migration in cardiac fibroblasts and stimulates phosphorylation of Akt and ERK as well as ROS production[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemerin-9 (149-157) (TFA) Related Antibodies

Western Blot Analysis[4]

Cell Line: Cardiac fibroblasts
Concentration: 0.1 nM
Incubation Time: 24 hours
Result: Stimulated phosphorylation of Akt and ERK.
In Vivo

Chemerin-9 (149-157) TFA (0.2 mg/kg; i.p.; daily, for 42 days) alleviates glucose intolerance and IR in PDM mice[1].
Chemerin-9 (149-157) TFA (7.7 μg /kg; i.h.; daily, for 28 days) has anti-inflammatory and anti-angiogenic effects in ApoE-/- mice and protects the abdominal aorta from MMP damage[2].
Chemerin-9 (149-157) TFA (8 μg/kg; ICV; daily; for 14 d; male Kunming mice) ameliorates Aβ1-42-induced memory impairment[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: PDM mice[1]
Dosage: 0.2 mg/kg
Administration: Intraperitoneal injection; daily, for 42 days
Result: Increased expression of chemerin, GLUT2, and PDX1, which led to the alleviation of glucose intolerance and IR in PDM model mice.
Animal Model: ApoE-/- mice[2]
Dosage: 7.7 μg /kg
Administration: Subcutaneous injection; daily, for 28 days
Result: Suppressed the enlargement of abdominal aorta and reversed the SMC loss.
Animal Model: ApoE-/- mice[2]
Dosage: 7.7 μg /kg
Administration: Subcutaneous injection; daily, for 28 days
Result: Down-regulated MMP2 and MMP-9 expression and decreased the levels of chemerin and CMKLR1.
Animal Model: Male Kunming mice[3]
Dosage: 8 μg/kg
Administration: Intracerebroventrical injection; daily; for 14 days
Result: Increased in the levels of pro-inflammatory cytokines such as interleukin-1β (IL-1β), tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) in the hippocampus.
Molecular Weight

1177.18

Formula

C56H67F3N10O15
Appearance

Solid

Color

White to off-white

Sequence Shortening

YFPGQFAFS
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 10 mg/mL (8.49 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8495 mL 4.2474 mL 8.4949 mL
5 mM 0.1699 mL 0.8495 mL 1.6990 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.8495 mL 4.2474 mL 8.4949 mL 21.2372 mL
5 mM 0.1699 mL 0.8495 mL 1.6990 mL 4.2474 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Chemerin-9 (149-157) (TFA) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chemerin-9 (149-157) (TFA)Chemerin ReceptorAktERKReactive Oxygen SpeciesAmyloid-βPKBProtein kinase BExtracellular signal regulated kinasesβ-amyloid peptideAβAbetaCMKLR1anti-inflammatoryimmune responsesadipocyte differentiationglucose metabolismInhibitorinhibitorinhibit

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