2. Apoptosis NF-κB Metabolic Enzyme/Protease Immunology/Inflammation Protein Tyrosine Kinase/RTK
  3. Apoptosis Reactive Oxygen Species VEGFR
  4. VEGFR-2-IN-52

VEGFR-2-IN-52 (compound 14d) is a potent VEGFR-2 inhibitor with an IC50 value of 191.1 nM. VEGFR-2-IN-52 decreases the protein expression of p-VEGFR-2, MMP9, p-ERK1/2 and p-MEK1. VEGFR-2-IN-52 shows cytotoxicity. VEGFR-2-IN-52 induces apoptosis and cell cycle arrest at G0/G1 phase. VEGFR-2-IN-52 increases the levels of ROS.

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VEGFR-2-IN-52 Chemical Structure

VEGFR-2-IN-52 Chemical Structure

CAS No. : 3046428-94-5

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VEGFR-2-IN-52 Related Antibodies

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

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Description

VEGFR-2-IN-52 (compound 14d) is a potent VEGFR-2 inhibitor with an IC50 value of 191.1 nM. VEGFR-2-IN-52 decreases the protein expression of p-VEGFR-2, MMP9, p-ERK1/2 and p-MEK1. VEGFR-2-IN-52 shows cytotoxicity. VEGFR-2-IN-52 induces apoptosis and cell cycle arrest at G0/G1 phase. VEGFR-2-IN-52 increases the levels of ROS[1].

Molecular Weight

420.96

Formula

C20H25ClN4O2S
CAS No.
SMILES

ClC1=CC=C(C2=CSC(NC(NCCCCN3CCCC3)=O)=C2C(N)=O)C=C1
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VEGFR-2-IN-52 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VEGFR-2-IN-523046428-94-5ApoptosisReactive Oxygen SpeciesVEGFRVascular endothelial growth factor receptorA549 cellscytotoxicityROSp-VEGFR-2MMP9p-ERK1/2p-MEK1apoptosisG0/G1 phaseInhibitorinhibitorinhibit

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