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Intermediate of Exatecan

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (19) ADC Linker (2) Drug-Linker Conjugates for ADC (1) Isotope-Labeled Compounds (1) Topoisomerase (17)
By Research Areas:	Cancer (20)

Inhibitors & Agonists

Isotope-Labeled Compounds

Targets Recommended: Drug Intermediate Nuclear Factor of activated T Cells (NFAT)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-42487

Exatecan Intermediate 1	ADC Cytotoxin Topoisomerase	Cancer
Exatecan Intermediate 1 (compound 6) is an intermediate of Exatecan (DX-8951, HY-13631). Exatecan is an anticancer agent belonging to the class of camptothecin analogs. Exatecan can serve as the cytotoxic component of ADCs, disrupting tumor cell proliferation and division by interacting with DNA, thereby inhibiting tumor growth. Exatecan is primarily used for research of a variety of cancers including ovarian, lung and breast cancers .

HY-42487A

*(rac)-Exatecan* Intermediate 1**	ADC Cytotoxin Topoisomerase	Cancer
(rac)-Exatecan Intermediate 1 is an isomer of Exatecan Intermediate 1 (HY-42487). Exatecan Intermediate 1 (compound 6) is an intermediate of Exatecan (HY-13631), a camptothecin-based anticancer agent. Exatecan inhibits tumor growth by interfering with the proliferation and division of tumor cells by interacting with DNA. Exatecan is primarily used in research into a variety of cancers including ovarian, lung and breast cancer .

HY-42487B

*(R)-Exatecan* Intermediate 1**	ADC Cytotoxin Topoisomerase	Cancer
(R)-Exatecan Intermediate 1 is an isomer of Exatecan Intermediate 1 (HY-42487). Exatecan Intermediate 1 (compound 6) is an intermediate of Exatecan (HY-13631), a camptothecin-based anticancer agent. Exatecan inhibits tumor growth by interfering with the proliferation and division of tumor cells by interacting with DNA. Exatecan is primarily used in research into a variety of cancers including ovarian, lung and breast cancer .

HY-42487S

Exatecan Intermediate 1-d5	Isotope-Labeled Compounds ADC Cytotoxin Topoisomerase	Others
Exatecan Intermediate 1-d₅ is the deuterium labeled Exatecan Intermediate 1 .

HY-43564

Exatecan Intermediate 5	ADC Cytotoxin Topoisomerase	Cancer
Exatecan Intermediate 5 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 5 can be used to synthesize Antibody-Drug Conjugates (ADCs).

HY-44369

Exatecan Intermediate 6	ADC Cytotoxin Topoisomerase	Cancer
Exatecan Intermediate 6 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 6 can be used to synthesize Antibody-Drug Conjugates (ADCs).

HY-45157

Exatecan Intermediate 7	ADC Cytotoxin Topoisomerase	Cancer
Exatecan Intermediate 7 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 7 can be used to synthesize Antibody-Drug Conjugates (ADCs).

HY-43565B

Exatecan intermediate 10	ADC Cytotoxin Topoisomerase	Cancer
Exatecan intermediate 10 is an intermediate in the synthesis of Exatecan (HY-13631).Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 of 2 .2 μM (0 .975 μg/mL) for use in cancer research .

HY-45171

Exatecan intermediate 12	ADC Cytotoxin	Cancer
Exatecan intermediate 12 is an intermediate for the synthesis of ADC toxin Exatecan (HY-13631) and can be used to prepare ADC compounds .

HY-46081

Exatecan Intermediate 3	ADC Cytotoxin Topoisomerase	Cancer
Exatecan Intermediate 3 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 3 can be used to synthesize Antibody-Drug Conjugates (ADCs).

HY-W021377C

Exatecan Intermediate 4 dihydrochloride	ADC Cytotoxin Topoisomerase	Cancer
Exatecan Intermediate 4 dihydrochloride is an intermediate of Exatecan (DX-8951, HY-13631). Exatecan is an anticancer agent belonging to the class of camptothecin analogs. Exatecan interferes with the proliferation and division of tumor cells by interacting with DNA, thereby inhibiting tumor growth. Exatecan is primarily used for research of a variety of cancers including ovarian, lung and breast cancers .

HY-W021377

Exatecan Intermediate 2	ADC Cytotoxin Topoisomerase	Cancer
Exatecan Intermediate 2 (compound B) is an intermediate of Exatecan (DX-8951, HY-13631). Exatecan is an anticancer agent belonging to the class of camptothecin analogs. Exatecan interferes with the proliferation and division of tumor cells by interacting with DNA, thereby inhibiting tumor growth. Exatecan is primarily used for research of a variety of cancers including ovarian, lung and breast cancers .

HY-W021377A

Exatecan Intermediate 2 hydrochloride	ADC Cytotoxin Topoisomerase	Cancer
Exatecan Intermediate 2 hydrochloride (compound B) is an intermediate of Exatecan (DX-8951, HY-13631). Exatecan is an anticancer agent belonging to the class of camptothecin analogs. Exatecan interferes with the proliferation and division of tumor cells by interacting with DNA, thereby inhibiting tumor growth. Exatecan is primarily used for research of a variety of cancers including ovarian, lung and breast cancers .

HY-W021377B

Exatecan Intermediate 4	ADC Cytotoxin Topoisomerase	Cancer
Exatecan Intermediate 4 (compound B) is an intermediate of Exatecan (DX-8951, HY-13631). Exatecan is an anticancer agent belonging to the class of camptothecin analogs. Exatecan interferes with the proliferation and division of tumor cells by interacting with DNA, thereby inhibiting tumor growth. Exatecan is primarily used for research of a variety of cancers including ovarian, lung and breast cancers .

HY-400316

Exatecan intermediate 8	ADC Cytotoxin Topoisomerase	Cancer
Exatecan intermediate 8 is an intermediate for the synthesis of Exatecan (HY-13631). Exatecan (DX-8951) is a common toxin component in ADC preparation (ADC Cytotoxin) and an inhibitor of DNA topoisomerase I (IC50=2.2 μM) .

HY-43565

Exatecan intermediate 9	ADC Cytotoxin Topoisomerase	Cancer
Exatecan intermediate 9 is an intermediate for the synthesis of Exatecan (HY-13631). Exatecan (DX-8951) is a common toxin component in ADC preparation (ADC Cytotoxin) and an inhibitor of DNA topoisomerase I (IC50=2.2 μM) .

HY-49861

Exatecan intermediate 11	ADC Cytotoxin Topoisomerase	Cancer
Exatecan intermediate 11 is an intermediate for the synthesis of Exatecan (HY-13631). Exatecan (DX-8951) is a common toxin component in ADC preparation (ADC Cytotoxin) and an inhibitor of DNA topoisomerase I (IC50=2.2 μM) .

HY-153600

GGFG-amide-glycol-amide-Exatecan	Drug-Linker Conjugates for ADC Topoisomerase	Cancer
GGFG-amide-glycol-amide-Exatecan (Intermediate 2) is an Exatecan (HY-13631) derivative and can be used in the synthesis of antibody-drug conjugates (ADCs) .

HY-160885

NH2-Gly-PAB-Exatecan-D-glucuronic acid	ADC Cytotoxin	Others
NH2-Gly-PAB-Exatecan-D-glucuronic acid (Compound 8) is an intermediate, which reacts with NHS group to form drug-linker conjugate for ADC, Mal-Gly-PAB-Exatecan-D-glucuronic acid (HY-153179) .

HY-160885A

NH2-Gly-PAB-Exatecan-D-glucuronic acid formic	ADC Cytotoxin	Cancer
NH2-Gly-PAB-Exatecan-D-glucuronic acid formic (Compound 8) is the formic salt form of H2N-Gly-PAB-Exatecan-D-glucuronic acid. H2N-Gly-PAB-Exatecan-D-glucuronic acid formic is an intermediate, which reacts with NHS group to form drug-linker conjugate for ADC, Mal-Gly-PAB-Exatecan-D-glucuronic acid (HY-153179) .

HY-49412

Fmoc-Gly-Gly-Phe-Gly-NH-CH2-O-CO-CH3	Others	Others
Fmoc-Gly-Gly-Phe-Gly-NH-CH2-O-CO-CH3 (compound DC-13-C) is an intermediate in the synthesis of Exatecan (HY-13631) derivatives .

HY-46572

Benzyl 2-cyclopropyl-2-hydroxyacetate	ADC Linker	Cancer
Benzyl 2-cyclopropyl-2-hydroxyacetate is an intermediate in the synthesis of ADC linker.The linker composed of Benzyl 2-cyclopropyl-2-hydroxyacetate can be coupled to Exatecan (HY-13631) and combined with antibodies (such as antibody hu2F7) .

HY-W250541

Fmoc-Gly-NH-CH2-O-Cyclopropane-CH2COOH	ADC Linker	Cancer
Fmoc-Gly-NH-CH2-O-Cyclopropane-CH2COOH is an intermediate in the synthesis of ADC linker.The linker composed of Benzyl 2-cyclopropyl-2-hydroxyacetate can be coupled to Exatecan (HY-13631) and combined with antibodies (such as antibody hu2F7) .

Exatecan Intermediate 1-d5
Exatecan Intermediate 1-d₅ is the deuterium labeled Exatecan Intermediate 1 .

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