1. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  2. ADC Cytotoxin Topoisomerase
  3. Exatecan Intermediate 7

Exatecan Intermediate 7 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 7 can be used to synthesize Antibody-Drug Conjugates (ADCs).

For research use only. We do not sell to patients.

Exatecan Intermediate 7 Chemical Structure

Exatecan Intermediate 7 Chemical Structure

CAS No. : 182182-32-7

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
USD 220 In-stock
Solution
10 mM * 1 mL in DMSO USD 220 In-stock
Solid
25 mg USD 200 In-stock
50 mg USD 320 In-stock
100 mg USD 500 In-stock
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Description

Exatecan Intermediate 7 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 7 can be used to synthesize Antibody-Drug Conjugates (ADCs).

IC50 & Target

Camptothecins

 

Molecular Weight

264.25

Formula

C13H13FN2O3

CAS No.
Appearance

Solid

Color

Light green to green

SMILES

CC(NC(C=C(F)C(C)=C1CC/C2=N\O)=C1C2=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (378.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7843 mL 18.9215 mL 37.8429 mL
5 mM 0.7569 mL 3.7843 mL 7.5686 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.24%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7843 mL 18.9215 mL 37.8430 mL 94.6074 mL
5 mM 0.7569 mL 3.7843 mL 7.5686 mL 18.9215 mL
10 mM 0.3784 mL 1.8921 mL 3.7843 mL 9.4607 mL
15 mM 0.2523 mL 1.2614 mL 2.5229 mL 6.3072 mL
20 mM 0.1892 mL 0.9461 mL 1.8921 mL 4.7304 mL
25 mM 0.1514 mL 0.7569 mL 1.5137 mL 3.7843 mL
30 mM 0.1261 mL 0.6307 mL 1.2614 mL 3.1536 mL
40 mM 0.0946 mL 0.4730 mL 0.9461 mL 2.3652 mL
50 mM 0.0757 mL 0.3784 mL 0.7569 mL 1.8921 mL
60 mM 0.0631 mL 0.3154 mL 0.6307 mL 1.5768 mL
80 mM 0.0473 mL 0.2365 mL 0.4730 mL 1.1826 mL
100 mM 0.0378 mL 0.1892 mL 0.3784 mL 0.9461 mL
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Exatecan Intermediate 7
Cat. No.:
HY-45157
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