2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. ADC Cytotoxin Topoisomerase
  4. (R)-Exatecan Intermediate 1

(R)-Exatecan Intermediate 1 is an isomer of Exatecan Intermediate 1 (HY-42487). Exatecan Intermediate 1 (compound 6) is an intermediate of Exatecan (HY-13631), a camptothecin-based anticancer agent. Exatecan inhibits tumor growth by interfering with the proliferation and division of tumor cells by interacting with DNA. Exatecan is primarily used in research into a variety of cancers including ovarian, lung and breast cancer.

For research use only. We do not sell to patients.

(R)-Exatecan Intermediate 1 Chemical Structure

(R)-Exatecan Intermediate 1 Chemical Structure

CAS No. : 110351-91-2

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Other Forms of (R)-Exatecan Intermediate 1:

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Description

(R)-Exatecan Intermediate 1 is an isomer of Exatecan Intermediate 1 (HY-42487). Exatecan Intermediate 1 (compound 6) is an intermediate of Exatecan (HY-13631), a camptothecin-based anticancer agent. Exatecan inhibits tumor growth by interfering with the proliferation and division of tumor cells by interacting with DNA. Exatecan is primarily used in research into a variety of cancers including ovarian, lung and breast cancer[1][2].

IC50 & Target

Camptothecins

 

Molecular Weight

263.25

Formula

C13H13NO5
CAS No.
Appearance

Solid

Color

Light yellow to light brown

SMILES

O=C1[C@@](O)(CC)C(C=C23)=C(CO1)C(N3CCC2=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (379.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7987 mL 18.9934 mL 37.9867 mL
5 mM 0.7597 mL 3.7987 mL 7.5973 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

V1

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7987 mL 18.9934 mL 37.9867 mL 94.9668 mL
5 mM 0.7597 mL 3.7987 mL 7.5973 mL 18.9934 mL
10 mM 0.3799 mL 1.8993 mL 3.7987 mL 9.4967 mL
15 mM 0.2532 mL 1.2662 mL 2.5324 mL 6.3311 mL
20 mM 0.1899 mL 0.9497 mL 1.8993 mL 4.7483 mL
25 mM 0.1519 mL 0.7597 mL 1.5195 mL 3.7987 mL
30 mM 0.1266 mL 0.6331 mL 1.2662 mL 3.1656 mL
40 mM 0.0950 mL 0.4748 mL 0.9497 mL 2.3742 mL
50 mM 0.0760 mL 0.3799 mL 0.7597 mL 1.8993 mL
60 mM 0.0633 mL 0.3166 mL 0.6331 mL 1.5828 mL
80 mM 0.0475 mL 0.2374 mL 0.4748 mL 1.1871 mL
100 mM 0.0380 mL 0.1899 mL 0.3799 mL 0.9497 mL
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(R)-Exatecan Intermediate 1 Related Classifications

Keywords:

(R)-Exatecan Intermediate 1110351-91-2ADC CytotoxinTopoisomeraseADC PayloadInhibitorinhibitorinhibit

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